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CAS 149920-56-9

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Idraparinux

Description:
Idraparinux is a synthetic anticoagulant that belongs to the class of drugs known as factor Xa inhibitors. It is characterized by its long half-life, which allows for once-weekly dosing, making it a convenient option for patients requiring anticoagulation therapy. Idraparinux works by inhibiting factor Xa, an essential enzyme in the coagulation cascade, thereby preventing the formation of thrombin and subsequent blood clot formation. This mechanism of action positions it as a potential treatment for conditions such as venous thromboembolism and atrial fibrillation. The substance is administered via subcutaneous injection and is notable for its high bioavailability. However, idraparinux has been associated with a risk of bleeding, a common side effect of anticoagulants, and its use requires careful monitoring. Additionally, it is important to note that idraparinux has been largely replaced in clinical practice by newer anticoagulants with improved safety profiles and more predictable pharmacokinetics.
Formula:C38H64O49S7·9Na
InChI:InChI=1S/C38H64O49S7.9Na/c1-64-15-12(9-72-88(43,44)45)76-35(27(68-5)18(15)65-2)80-21-19(66-3)28(69-6)37(82-25(21)32(39)40)79-17-14(11-74-90(49,50)51)77-38(31(87-94(61,62)63)24(17)85-92(55,56)57)81-22-20(67-4)29(70-7)36(83-26(22)33(41)42)78-16-13(10-73-89(46,47)48)75-34(71-8)30(86-93(58,59)60)23(16)84-91(52,53)54;;;;;;;;;/h12-31,34-38H,9-11H2,1-8H3,(H,39,40)(H,41,42)(H,43,44,45)(H,46,47,48)(H,49,50,51)(H,52,53,54)(H,55,56,57)(H,58,59,60)(H,61,62,63);;;;;;;;;/t12-,13-,14-,15-,16-,17-,18+,19+,20+,21+,22+,23+,24+,25+,26-,27-,28-,29-,30-,31-,34+,35-,36-,37-,38-;;;;;;;;;/m1........./s1
InChI key:InChIKey=ZJUNHVJPEJJPQS-MCPDASDXSA-N
SMILES:O([C@H]1[C@H](OS(=O)(=O)O)[C@@H](OS(=O)(=O)O)[C@@H](O[C@H]2[C@H](OC)[C@@H](OC)[C@H](O[C@H]3[C@H](OS(=O)(=O)O)[C@@H](OS(=O)(=O)O)[C@@H](OC)O[C@@H]3COS(=O)(=O)O)O[C@H]2C(O)=O)O[C@@H]1COS(=O)(=O)O)[C@H]4[C@H](OC)[C@@H](OC)[C@H](O[C@@H]5[C@H](OC)[C@@H](OC)[C@H](OC)[C@@H](COS(=O)(=O)O)O5)[C@@H](C(O)=O)O4.[Na]
Synonyms:
  • Idraparinux sodium
  • SANORG 34006
  • α-D-Glucopyranoside, methyl O-2,3,4-tri-O-methyl-6-O-sulfo-α-D-glucopyranosyl-(1→4)-O-2,3-di-O-methyl-β-D-glucopyranuronosyl-(1→4)-O-2,3,6-tri-O-sulfo-α-D-glucopyranosyl-(1→4)-O-2,3-di-O-methyl-α-L-idopyranuronosyl-(1→4)-, 2,3,6-tris(hydrogen sulfate), sodium salt (1:9)
  • α-D-Glucopyranoside, methyl O-2,3,4-tri-O-methyl-6-O-sulfo-α-D-glucopyranosyl-(1→4)-O-2,3-di-O-methyl-β-D-glucopyranuronosyl-(1→4)-O-2,3,6-tri-O-sulfo-α-D-glucopyranosyl-(1→4)-O-2,3-di-O-methyl-α-L-idopyranuronosyl-(1→4)-, 2,3,6-tris(hydrogen sulfate), nonasodium salt
  • Org 34006
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