CAS 149934-21-4

9-Amino Minocycline Hydrochloride

Description:

9-Amino Minocycline Hydrochloride is a derivative of minocycline, a broad-spectrum antibiotic belonging to the tetracycline class. This compound is characterized by the presence of an amino group at the 9-position of the minocycline structure, which enhances its antibacterial activity and pharmacological properties. It is typically presented as a hydrochloride salt, which improves its solubility in aqueous solutions, making it suitable for various pharmaceutical formulations. The substance exhibits a wide range of antibacterial activity against both Gram-positive and Gram-negative bacteria, and it is often used in the treatment of infections, including those caused by resistant strains. Additionally, 9-Amino Minocycline Hydrochloride has anti-inflammatory properties, which can be beneficial in treating conditions like acne and other dermatological disorders. Its mechanism of action involves inhibiting bacterial protein synthesis by binding to the 30S ribosomal subunit. As with other tetracyclines, it is important to consider potential side effects and contraindications, including photosensitivity and interactions with certain metal ions.

Formula: C₂₃H₂₈N₄O₇·ClH

InChI: InChI=1S/C23H28N4O7.ClH/c1-26(2)12-7-11(24)17(28)14-9(12)5-8-6-10-16(27(3)4)19(30)15(22(25)33)21(32)23(10,34)20(31)13(8)18(14)29;/h7-8,10,16,28,30-31,34H,5-6,24H2,1-4H3,(H2,25,33);1H/t8-,10-,16-,23-;/m0./s1

InChI key: InChIKey=KYFXMIINWSZGCG-KBTHSJHISA-N

SMILES: O[C@]12[C@]([C@H](N(C)C)C(O)=C(C(N)=O)C1=O)(C[C@]3(C(=C2O)C(=O)C=4C(C3)=C(N(C)C)C=C(N)C4O)[H])[H].Cl

Synonyms:

• (4S,4As,5Ar,12As)-9-Amino-4,7-Bis(Dimethylamino)-1,4,4A,5,5A,6,11,12A-Octahydro-3,10,12,12A-Tetrahydroxy-1,11-Dioxo-2-Naphthacenecarboxamide Hydrochloride
• (4S,4As,5Ar,12As)-9-Amino-4,7-Bis(Dimethylamino)-1,4,4A,5,5A,6,11,12A-Octahydro-3,10,12,12A-Tetrahydroxy-1,11-Dioxo-2-Naphthacenecarboxamide Hydrochloride (1:1)
• (4S,4aS,5aR,12aS)-9-amino-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide sulfate (1:1)
• 2-Naphthacenecarboxamide, 9-amino-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, hydrochloride (1:1), (4S,4aS,5aR,12aS)-
• 2-Naphthacenecarboxamide, 9-amino-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, monohydrochloride, [4S-(4α,4aα,5aα,12aα)]-
• 9-Aminominocycline hydrochloride
• 9-Amino-minocycline hydrochloride

TIGECYCLINE IMPURITY B CRS

CAS: 149934-21-4

TIGECYCLINE IMPURITY B CRS

Ref: 41-Y0001944

Tigecycline Related Compound B ((4S,4aS,5aR,12aS)-9-Amino-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2- carboxamide hydrochloride (1:x))

CAS: 149934-21-4

Aromatic cyclic amides (including cyclic carbamates) and their derivatives; salts thereof

Formula: C₂₃H₂₈N₄O₇·HCl

Color and Shape: Off-White Powder

Molecular weight: 472.1958

Ref: 45-1667665

9-Amino minocycline, HCl

CAS: 149934-21-4

Formula: C₂₃H₂₉ClN₄O₇

Purity: 96%

Color and Shape: Solid

Molecular weight: 508.9520

Ref: IN-DA001M59

(4S,4aS,5aR,12aS)-9-Amino-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride

CAS: 149934-21-4

(4S,4aS,5aR,12aS)-9-Amino-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride

Purity: 95%

Molecular weight: 508.95g/mol

Ref: 54-OR1031852

Tigecycline EP Impurity B HCl (Tigecycline Metabolite M6 HCl, 9-Amino Minocycline HCl)

CAS: 149934-21-4

Formula: C₂₃H₂₈N₄O₇·HCl

Color and Shape: Yellow Solid

Molecular weight: 472.50 36.46

Ref: 4Z-T-109008

Tigecycline EP Impurity B

CAS: 149934-21-4

Formula: C₂₃H₂₈N₄O₇HCl

Molecular weight: 472.50 : 36.5

Ref: ST-EA-CP-T74002

9-Amino minocycline hydrochloride

CAS: 149934-21-4

Purity: 95%

Molecular weight: 508.9599915

Ref: 10-F694888

9-Aminominocycline Hydrochloride (~90%)

Controlled Product

CAS: 149934-21-4

Applications 9-Aminominocycline Hydrochloride is a metabolite of Minocycline Hydrochloride (M344800); a second generation tetracycline antibiotic and antibacterial.
References Zbinovsky, V., et al.: Anal. Profiles Drug Subs., 6, 323 (1977); Oringer, R.J., et al.: J. Periodontol., 73, 835 (2002)

Formula: C₂₃H₂₈N₄O₇•HCl

Purity: ~90%

Color and Shape: Neat

Molecular weight: 508.95

Ref: TR-A618185

9-Aminominocycline hydrochloride

CAS: 149934-21-4

Aminominocycline hydrochloride is a synthetic, catalytic compound. It is used as a reaction solution in organic solvents and has been shown to be an effective inhibitor of sulfate-reducing bacteria, such as Desulfovibrio desulfuricans. Aminominocycline hydrochloride has been found to be effective against human serum at a flow rate of 1 mL/min, but not at higher flow rates, likely due to its ability to react with the chloride ion. This product can be used for analytical methods in the determination of triazine and high yield chloride. Aminominocycline hydrochloride is also known to react with monoclonal antibodies and can be used for the detection of pollutants.

Formula: C₂₃H₂₈N₄O₇·HCl

Purity: Min. 80 Area-%

Color and Shape: Yellow Powder

Molecular weight: 508.95 g/mol

Ref: 3D-FA10811