CAS 149968-26-3

Elisartan

Description:

Elisartan, with the CAS number 149968-26-3, is an angiotensin II receptor antagonist primarily used in the treatment of hypertension. It functions by selectively blocking the action of angiotensin II, a potent vasoconstrictor, thereby promoting vasodilation and reducing blood pressure. The substance is characterized by its chemical structure, which includes a biphenyl group and a carboxylic acid moiety, contributing to its pharmacological activity. Elisartan is typically administered orally and exhibits a favorable pharmacokinetic profile, including good absorption and a relatively long half-life, allowing for once-daily dosing. It is generally well-tolerated, with common side effects including dizziness and fatigue. As with other medications in its class, it may also have protective effects on renal function, making it beneficial for patients with certain comorbidities. Overall, Elisartan represents a valuable option in the management of hypertension, contributing to cardiovascular health.

Formula: C₂₇H₂₉ClN₆O₅

InChI: InChI=1S/C27H29ClN6O5/c1-4-6-11-22-29-24(28)23(26(35)38-17(3)39-27(36)37-5-2)34(22)16-18-12-14-19(15-13-18)20-9-7-8-10-21(20)25-30-32-33-31-25/h7-10,12-15,17H,4-6,11,16H2,1-3H3,(H,30,31,32,33)

InChI key: InChIKey=IDAWWPOAHPVPMY-UHFFFAOYSA-N

SMILES: C(N1C(C(OC(OC(OCC)=O)C)=O)=C(Cl)N=C1CCCC)C2=CC=C(C=C2)C3=C(C=CC=C3)C=4NN=NN4

Synonyms:

• (±)-1-((Ethoxycarbonyl)oxy)ethyl 2-Butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl)-1H-imidazole-5-carboxylate
• 1-[(ethoxycarbonyl)oxy]ethyl 2-butyl-4-chloro-1-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylate
• 1H-Imidazole-5-carboxylic acid, 2-butyl-4-chloro-1-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-, 1-[(ethoxycarbonyl)oxy]ethyl ester
• 1H-imidazole-5-carboxylic acid, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, 1-[(ethoxycarbonyl)oxy]ethyl ester
• 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic Acid (±)-1-[(Ethoxycarbonyl)oxy]ethyl Ester
• Hn 65021
• Elisartan

Elisartan

CAS: 149968-26-3

Elisartan is an angiotensin II receptor blocker (ARB), which is derived from chemical synthesis with a mechanism of action centered around the selective inhibition of the angiotensin II type 1 (AT1) receptors. By obstructing these receptors, Elisartan effectively inhibits the vasoconstrictive and aldosterone-secreting effects of angiotensin II, which leads to the relaxation of blood vessels, a decrease in blood pressure, and reduced strain on the heart.

Formula: C₂₇H₂₉ClN₆O₅

Purity: Min. 95%

Molecular weight: 553 g/mol

Ref: 3D-ZFA96826

Elisartan

CAS: 149968-26-3

Elisartan is a non-peptide pro-drug of angiotensin II AT1 receptor antagonist HN-12206. It also shows anti-hypertension activities.

Formula: C₂₇H₂₉ClN₆O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 553.01

Ref: TM-T15208