CAS 149989-68-4

Guanosine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-[(1,1-dimethylethyl)dimethylsilyl]-N-[[4-(1,1-dimethylethyl)phenoxy]acetyl]-, 3′-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

Description:

Guanosine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-[(1,1-dimethylethyl)dimethylsilyl]-N-[[4-(1,1-dimethylethyl)phenoxy]acetyl]-, 3′-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] is a complex chemical compound primarily used in the field of nucleic acid chemistry, particularly in the synthesis of oligonucleotides. This compound features a guanosine base, which is one of the four nucleobases in RNA, linked to various protective and functional groups that enhance its stability and reactivity during synthesis. The presence of dimethylsilyl and cyanoethyl groups indicates that it is designed for specific applications in chemical synthesis, likely to improve solubility and protect against hydrolysis. The bis(4-methoxyphenyl) and phenylmethyl moieties suggest that the compound may also exhibit unique electronic properties, potentially influencing its interactions in biological systems. Overall, this compound is characterized by its intricate structure, which is tailored for use in advanced biochemical applications, particularly in the synthesis of modified RNA or DNA sequences.

Formula: C₅₈H₇₆N₇O₁₀PSi

InChI: InChI=1S/C58H76N7O10PSi/c1-38(2)65(39(3)4)76(72-34-18-33-59)74-50-47(35-71-58(41-19-16-15-17-20-41,42-23-27-44(68-11)28-24-42)43-25-29-45(69-12)30-26-43)73-54(51(50)75-77(13,14)57(8,9)10)64-37-60-49-52(64)62-55(63-53(49)67)61-48(66)36-70-46-31-21-40(22-32-46)56(5,6)7/h15-17,19-32,37-39,47,50-51,54H,18,34-36H2,1-14H3,(H2,61,62,63,66,67)/t47-,50-,51-,54-,76?/m1/s1

InChI key: InChIKey=ODCBQUOWLVQKQG-PZUNXSRFSA-N

SMILES: C(OC[C@@H]1[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](O[Si](C(C)(C)C)(C)C)[C@@H](O1)N2C3=C(N=C2)C(=O)N=C(NC(COC4=CC=C(C(C)(C)C)C=C4)=O)N3)(C5=CC=C(OC)C=C5)(C6=CC=C(OC)C=C6)C7=CC=CC=C7

Synonyms:

• 5'-O-DMT-2'-TBDMS-rG(N-tac)-3'-CEDPA
• Guanosine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-[(1,1-dimethylethyl)dimethylsilyl]-N-[[4-(1,1-dimethylethyl)phenoxy]acetyl]-, 3′-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

2'-O-tert-Butyldimethylsilyl-N-(tert-butylphenoxyacetyl)-5'-O-DMT-guanosine 3'-CE phosphoramidite

CAS: 149989-68-4

2'-O-tert-Butyldimethylsilyl-N-(tert-butylphenoxyacetyl)-5'-O-DMT-guanosine 3'-CE phosphoramidite is a synthetic nucleoside analog. The chemical name for this product is 2'-O-tert-butyldimethylsilyl-N-(tert-butylphenoxyacetyl)-5'-O-dimethoxytritylguanosine 3'-cyanoethylphosphoramidite. The molecular formula is C28H34N2O8PSi, and the molecular weight is 812.59 g/mol. This product has an EC Number of 61317 - CAS Number of 149989 - 68 - 4 and a melting point of 232°C (238°F). This compound can be used in the synthesis of oligonucleotides that are used to bind to RNA and

Formula: C₅₈H₇₆N₇O₁₀PSi

Purity: Min. 95%

Molecular weight: 1,090.32 g/mol

Ref: 3D-PB63474