CAS 150374-95-1

Sivelestat Sodium

Description:

Sivelestat sodium is a synthetic small molecule that acts as a selective inhibitor of neutrophil elastase, an enzyme involved in the inflammatory response. It is primarily used in research and clinical settings to mitigate acute lung injury and acute respiratory distress syndrome (ARDS) by reducing neutrophil-mediated tissue damage. The compound is characterized by its ability to modulate inflammatory processes, making it a potential therapeutic agent in conditions where excessive neutrophil activity is detrimental. Sivelestat sodium is typically administered intravenously and has been studied for its pharmacokinetics, safety profile, and efficacy in various clinical trials. Its mechanism of action involves the inhibition of neutrophil elastase, which helps to preserve lung function and reduce inflammation. Additionally, it is important to note that while Sivelestat sodium shows promise in treating inflammatory conditions, its use should be guided by clinical evidence and regulatory approvals. As with any pharmaceutical agent, potential side effects and contraindications should be carefully considered in a clinical context.

Formula: C₂₀H₂₁N₂NaO₇S

InChI: InChI=1/C20H22N2O7S.Na/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24;/h4-11,22H,12H2,1-3H3,(H,21,25)(H,23,24);/q;+1/p-1

InChI key: InChIKey=YIPPOMHPJSWADI-UHFFFAOYSA-N

SMILES: C(NCC(O)=O)(=O)C1=C(NS(=O)(=O)C2=CC=C(OC(C(C)(C)C)=O)C=C2)C=CC=C1.[Na]

Synonyms:

• Glycine, N-[2-[[[4-(2,2-dimethyl-1-oxopropoxy)phenyl]sulfonyl]amino]benzoyl]-, monosodium salt
• ONO 5046-Na
• Propanoic acid, 2,2-dimethyl-, 4-[[[2-[[(carboxymethyl)amino]carbonyl]phenyl]amino]sulfonyl]phenyl ester, sodium salt (1:1)
• Sodium ({2-[({4-[(2,2-dimethylpropanoyl)oxy]phenyl}sulfonyl)amino]benzoyl}amino)acetate
• Sodium sivelestat
• Sivelestat sodium
• sodium 2-[[[2-[[4-(2,2-dimethyl-1-oxopropoxy)phenyl]sulfonylamino]phenyl]-oxomethyl]amino]acetate
• sodium,2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetate
• N-{2-[({4-[(2,2-Dimethylpropanoyl)oxy]phenyl}sulfonyl)amino]benzoyl}glycinesodiumsalt
• Sivelestat SodiuM anhydrous
• Sivelestat sodium salt
• N-[2-[[[4-(2,2-Dimethyl-1-oxopropoxy)phenyl]sulfonyl]amino]benzoyl]-(S)-glycine monosodium salt USP/EP/BP

N-[2-[[[4-(2,2-Dimethyl-1-oxopropoxy)phenyl]sulfonyl]amino]benzoyl]-(S)-glycine monosodium salt

CAS: 150374-95-1

Formula: C₂₀H₂₁N₂NaO₇S

Purity: 98%

Color and Shape: Solid

Molecular weight: 456.4447

Ref: IN-DA00AOG4

Sivelestat Sodium Salt

CAS: 150374-95-1

Formula: C₂₀H₂₁N₂O₇S·Na

Molecular weight: 433.46 22.99

Ref: 4Z-S-192002

Sivelestat sodium

CAS: 150374-95-1

Sivelestat sodium (EI 546 sodium) is a human neutrophil elastase inhibitor used in research on acute lung injury/acute respiratory distress syndrome.

Formula: C₂₀H₂₁N₂NaO₇S

Color and Shape: Solid

Molecular weight: 456.45

Ref: TM-T21414

Sivelestat Sodium

Controlled Product

CAS: 150374-95-1

Applications Sivelestat Sodium is an inhibitor of neutrophil elastase. Also, it is a promising therapeutic agent for severe acute pneumonitis caused by gefitinib.
References Sercundes, M. K., et al.: Plos Pathog., 12, 1006054/1-1006054/24 (2016); Mikumo, H., et al.: Biochem. Biophys. Res. Commun., 486, 205-209 (2017)

Formula: C₂₀H₂₁N₂NaO₇S

Color and Shape: Neat

Molecular weight: 456.44

Ref: TR-S497060