CAS 150375-75-0

SR 49059

Description:

SR 49059, with the CAS number 150375-75-0, is a chemical compound that functions primarily as a selective antagonist of the neuropeptide Y (NPY) Y1 receptor. This compound is notable for its potential applications in research related to obesity and metabolic disorders, as NPY is involved in appetite regulation and energy homeostasis. SR 49059 exhibits high affinity and specificity for the Y1 receptor, making it a valuable tool for studying the physiological roles of NPY signaling pathways. In terms of its chemical structure, SR 49059 is characterized by a specific arrangement of atoms that contributes to its biological activity. The compound is typically used in laboratory settings, and its effects are evaluated through various in vitro and in vivo studies. As with many research chemicals, safety and handling precautions are essential, as the full spectrum of its biological effects and potential side effects may not be completely understood.

Formula: C₂₈H₂₇Cl₂N₃O₇S

InChI: InChI=1S/C28H27Cl2N3O7S/c1-39-23-12-10-17(15-24(23)40-2)41(37,38)33-21-11-9-16(29)14-19(21)28(36,18-6-3-4-7-20(18)30)25(33)27(35)32-13-5-8-22(32)26(31)34/h3-4,6-7,9-12,14-15,22,25,36H,5,8,13H2,1-2H3,(H2,31,34)/t22-,25-,28+/m0/s1

InChI key: InChIKey=CEBYCSRFKCEUSW-NAYZPBBASA-N

SMILES: C(=O)([C@H]1[C@](O)(C=2C(N1S(=O)(=O)C3=CC(OC)=C(OC)C=C3)=CC=C(Cl)C2)C4=C(Cl)C=CC=C4)N5[C@H](C(N)=O)CCC5

Synonyms:

• 1-({(2R,3S)-5-chloro-3-(2-chlorophenyl)-1-[(3,4-dimethoxyphenyl)sulfonyl]-3-hydroxy-2,3-dihydro-1H-indol-2-yl}carbonyl)-L-prolinamide
• 1-({5-chloro-3-(2-chlorophenyl)-1-[(3,4-dimethoxyphenyl)sulfonyl]-3-hydroxy-2,3-dihydro-1H-indol-2-yl}carbonyl)prolinamide
• 2-Pyrrolidinecarboxamide, 1-[[(2R,3S)-5-chloro-3-(2-chlorophenyl)-1-[(3,4-dimethoxyphenyl)sulfonyl]-2,3-dihydro-3-hydroxy-1H-indol-2-yl]carbonyl]-, (2S)-
• 2-Pyrrolidinecarboxamide, 1-[[5-chloro-3-(2-chlorophenyl)-1-[(3,4-dimethoxyphenyl)sulfonyl]-2,3-dihydro-3-hydroxy-1H-indol-2-yl]carbonyl]-, [2R-[2α(S*),3β]]-
• Indol-2-Ylcarbonyl)-L-Prolinamide
• Relcovaptan
• Sr 49049
• Sr 49059

2-Pyrrolidinecarboxamide, 1-[[(2R,3S)-5-chloro-3-(2-chlorophenyl)-1-[(3,4-dimethoxyphenyl)sulfonyl]-2,3-dihydro-3-hydroxy-1H-indol-2-yl]carbonyl]-, (2S)-

CAS: 150375-75-0

Formula: C₂₈H₂₇Cl₂N₃O₇S

Purity: 99%

Color and Shape: Solid

Molecular weight: 620.5009

Ref: IN-DA001MJV

Relcovaptan (SR-49059)

CAS: 150375-75-0

Formula: C₂₈H₂₇Cl₂N₃O₇S

Molecular weight: 620.51

Ref: 4Z-R-097001

Relcovaptan

CAS: 150375-75-0

Stability Hygroscopic
Applications Relcovaptan is a selective vasopressin-1a receptor antagonist that prevents cellular swelling and provides treatment for post-traumatic brain edema.
References Marmarou, C.R., et. al.: Brain Res., 1581, 89 (2014)

Formula: C₂₈H₂₇Cl₂N₃O₇S

Color and Shape: Neat

Molecular weight: 620.50

Ref: TR-R143310

Relcovaptan-d6

Controlled Product

CAS: 150375-75-0

Formula: C₂₈H₂₁D₆Cl₂N₃O₇S

Color and Shape: Neat

Molecular weight: 626.54

Ref: TR-R143312

SR 49059

CAS: 150375-75-0

SR 49059 is a vasopressin antagonist that was developed to treat prostate cancer. SR 49059 binds to the vasopressin receptor and blocks the binding of vasopressin, thereby preventing vasoconstriction and lowering blood pressure. SR 49059 has been shown to be a potent and selective antagonist at the V2 receptor in human prostate cancer cells. The drug also possesses biochemical properties that are similar to oxytocin, which may account for its low potency in humans. SR 49059 has not been studied extensively in women or in humans with congestive heart failure, but it appears to have a positive effect on diastolic pressure.

Formula: C₂₈H₂₇Cl₂N₃O₇S

Purity: Min. 95%

Molecular weight: 620.5 g/mol

Ref: 3D-AGA37575

SR 49059

CAS: 150375-75-0

vasopressin V1A receptor antagonist

Formula: C₂₈H₂₇Cl₂N₃O₇S

Purity: 98%

Color and Shape: Solid

Molecular weight: 620.5

Ref: TM-T23393