CAS 150399-23-8

L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, disodium salt

Description:

L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, disodium salt, identified by CAS number 150399-23-8, is a complex organic compound that features both amino acid and pyrrolopyrimidine structures. This substance is characterized by its dual functionality, incorporating the properties of L-glutamic acid, which is a non-essential amino acid involved in various metabolic processes, and a pyrrolopyrimidine moiety that may contribute to its biological activity. The disodium salt form indicates that it has two sodium ions associated with the glutamic acid, enhancing its solubility in aqueous solutions. This compound may exhibit unique pharmacological properties, potentially acting as a modulator in biochemical pathways or serving as a precursor in drug synthesis. Its structural complexity suggests potential applications in medicinal chemistry, particularly in the development of therapeutics targeting neurological or metabolic disorders. As with many such compounds, understanding its stability, reactivity, and biological interactions is crucial for its application in research and medicine.

Formula: C₂₀H₁₉N₅Na₂O₆

InChI: InChI=1/C20H21N5O6.2Na.7H2O/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27;;;;;;;;;/h1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(H,30,31)(H4,21,22,24,25,29);;;7*1H2/q;2*+1;;;;;;;/p-2

InChI key: InChIKey=PSXPIRGEVYHPKP-GXKRWWSZSA-N

SMILES: C(CC1=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C1)C=2C3=C(NC2)NC(N)=NC3=O.[Na]

Synonyms:

• sodium 2-({4-[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}amino)pentanedioate hydrate (2:1:7)
• 2-[4-[2-(4-Amino-2-oxo-3,5,7-triazabicyclo[4.3.0]nona-3,8,10-trien-9-yl)ethyl]benzoyl]aminopentanedioic acid disodium salt
• N-{4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-D-glutamic acid
• Premetred disodium
• L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, sodium salt (1:2)
• 1H-Pyrrolo[2,3-d]pyrimidine, L-glutamic acid deriv.
• L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, disodium salt
• Pemetrexed disodium
• Tifolar
• PEMETREXED DISODIUM 2.5H2O
• ALIMTA
• N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt
• Alimt
• LY-231514
• Pemetrexed Dinatrium
• PEMETREXED DISODIUM FOR INJECTION BK-A-01
• PEMETREXED DISODIUM 99%
• PEMETREXED SODIUM
• N-[4-[(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid Disodium
• n-[4-[2-(2-amino-4,7-dihydro-4-oxo-1h-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid disodium salt
• PEMETREXED
• PEMETREXED DISODIUM(ALIMTA)
• PEMETREXED DISODIUM FOR INJECTION

Pemetrexed disodium

CAS: 150399-23-8

Pemetrexed disodium treats lung cancer/mesothelioma; may cause moderate serum enzyme elevation, rarely acute liver injury.

Formula: C₂₀H₁₉N₅Na₂O₆

Purity: 99.29% - 99.49%

Color and Shape: Crystalline Solid

Molecular weight: 471.37

Ref: TM-T0189L

L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, sodium salt (1:2)

CAS: 150399-23-8

Formula: C₂₀H₁₉N₅Na₂O₆

Purity: 99%

Color and Shape: Solid

Molecular weight: 471.3743

Ref: IN-DA001MKI

Pemetrexed disodium

CAS: 150399-23-8

Pemetrexed disodium

Purity: 99.9%

Molecular weight: 471.37g/mol

Ref: 54-OR1024614

Pemetrexed disodium

CAS: 150399-23-8

Pemetrexed disodium

Purity: ≥98%

Molecular weight: 471.37g/mol

Ref: 54-BUP15043

Pemetrexed-13C5 Disodium Salt

CAS: 150399-23-8

Formula: C₁₅₁₃C₅H₁₉N₅O₆·2Na

Color and Shape: White To Off-White Solid

Molecular weight: 430.35 2*22.99

Ref: 4Z-P-682

Pemetrexed Disodium Salt

CAS: 150399-23-8

Formula: C₂₀H₁₉N₅O₆·2Na

Color and Shape: White To Off-White Solid

Molecular weight: 425.40 2*22.99

Ref: 4Z-P-687

Pemetrexed-d5 Disodium Salt

Controlled Product

CAS: 1129408-57-6, 150399-23-8

Stability Hygroscopic
Applications Multitargeted antifolate; inhibits thymidylate synthase as well as other folate dependent enzymes. Antineoplastic.
References McDonald, A.C., et al.: Clin. Cancer Res., 4, 605 (1998), John, W., et al.: Cancer, 88, 1807 (2000), Miller, K.D., et al.: Ann. Oncol., 11, 101 (2000),

Formula: C₂₀H₁₄D₅N₅Na₂O₆

Color and Shape: Neat

Molecular weight: 476.41

Ref: TR-P219502

Pemetrexed-13C5 Disodium Heptahydrate

Controlled Product

CAS: 150399-23-8

Applications Pemetrexed-13C5 Disodium Salt, is the labeled analogue of Pemetrexed Disodium (P219500), used as Antineoplastic agent.
References McDonald, A.C., et al.: Clin. Cancer Res., 4, 605 (1998), John, W., et al.: Cancer, 88, 1807 (2000), Miller, K.D., et al.: Ann. Oncol., 11, 101 (2000),

Formula: C₁₅₁₃C₅H₁₉N₅Na₂O₆•7(H₂O)

Color and Shape: Off-White

Molecular weight: 476.3471802

Ref: TR-P219503

Pemetrexed disodium salt - Bio-X ™

CAS: 150399-23-8

Pemetrexed is an antifolate drug that is used to treat mesothelioma and non-small cell lung cancer. It is used during chemotherapy and sometimes used in conjunction with cisplatin. This drug disrupts folate-dependent metabolic activities essential for cell replication. In vitro studies have shown that Pemetrexed inhibits thymidylate synthase.

Formula: C₂₀H₁₉N₅Na₂O₆

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 471.37 g/mol

Ref: 3D-BP164243

Pemetrexed disodium

CAS: 150399-23-8

Thymidylate synthase inhibitor; antifolate antineoplastic agent

Formula: C₂₀H₁₉N₅Na₂O₆

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 471.37 g/mol

Ref: 3D-FP26784