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CAS 150408-83-6

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5(6)-carboxytetramethylrhodamine N-suc-cinimidyl ester

Description:
5(6)-Carboxytetramethylrhodamine N-succinimidyl ester, commonly referred to as TMR or TMR succinimidyl ester, is a fluorescent dye widely used in biochemical applications, particularly in labeling proteins and nucleic acids. This compound features a rhodamine core, which is known for its strong fluorescence properties, making it suitable for various imaging techniques. The presence of the carboxyl group enhances its solubility in aqueous solutions, while the N-succinimidyl ester moiety allows for efficient conjugation to amine-containing biomolecules, such as proteins and peptides, through nucleophilic attack. This reaction forms stable amide bonds, facilitating the study of biological processes through fluorescence microscopy or flow cytometry. The dye exhibits high photostability and brightness, which are critical for long-term imaging applications. Additionally, its spectral properties allow for multiplexing in experiments, enabling the simultaneous detection of multiple targets. Overall, TMR succinimidyl ester is a valuable tool in molecular biology and biochemistry for visualizing and tracking biomolecules in various experimental settings.
Formula:C29H25N3O7
InChI:InChI=1/C29H25N3O7/c1-30(2)17-6-9-21-23(14-17)37-24-15-18(31(3)4)7-10-22(24)29(21)20-8-5-16(13-19(20)28(36)38-29)27(35)39-32-25(33)11-12-26(32)34/h5-10,13-15H,11-12H2,1-4H3
SMILES:CN(C)c1ccc2c(c1)Oc1cc(ccc1C12c2ccc(cc2C(=O)O1)C(=O)ON1C(=O)CCC1=O)N(C)C
Synonyms:
  • 5(6)-Carboxytetramethylrhodamine N-succinimidyl ester
  • (2,5-Dioxopyrrolidin-1-Yl) 3',6'-Bis(Dimethylamino)-3-Oxo-Spiro[Isobenzofuran-1,9'-Xanthene]-5-Carboxylate
  • 5(6)-Carboxytetramethylrhodamine Succinimidyl Ester
  • 9-[2-Carboxy-4(or 5)-[[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl]phenyl]-3,6-bis(dimethylamino)-xanthylium inner salt
  • 5(6)-Tamra,Se
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