CAS 1505514-27-1

Taletrectinib free base

CAS: 1505514-27-1

Taletrectinib free base

Purity: ≥98%

Molecular weight: 405.47g/mol

Ref: 54-BUP02929

Taletrectinib free base

CAS: 1505514-27-1

Taletrectinib (AB-106) is a potent, selective oral ROS1/NTRK inhibitor with low IC50s against ROS1 and NTRK1-3, including Crizotinib-resistant mutations.

Formula: C₂₃H₂₄FN₅O

Purity: 99.98%

Color and Shape: Solid

Molecular weight: 405.47

Ref: TM-T38995

Taletrectinib

CAS: 1505514-27-1

Taletrectinib is a potent and selective small molecule activator of the MET receptor tyrosine kinase. It has been shown to have anti-cancer activity in preclinical models of cancer by inducing tumor cell apoptosis, inhibiting tumor growth, and preventing metastasis. Taletrectinib has also been shown to inhibit the activation of downstream signaling pathways that are important for cancer cell proliferation, including PI3K/AKT and MAPK/ERK. Ligand binding experiments conducted on recombinant MET indicate that taletrectinib binds to an allosteric site on MET and inhibits receptor activation with an IC50 value of 0.5 nM.

Formula: C₂₃H₂₄FN₅O

Purity: Min. 95%

Molecular weight: 405.5 g/mol

Ref: 3D-FKC51427