CAS 150629-67-7

Fmoc-Lys(Dde)-OH

Description:

Fmoc-Lys(Dde)-OH, with the CAS number 150629-67-7, is a protected amino acid derivative commonly used in peptide synthesis. It features a phenylmethoxycarbonyl (Fmoc) group, which serves as a protective group for the amino group of lysine (Lys), allowing for selective reactions during peptide assembly. The Dde (N,N-dimethyl-2,4-dimethoxybenzyl) group is another protective moiety that can be removed under specific conditions, enabling the introduction of further functional groups or the formation of complex structures. This compound is typically white to off-white in appearance and is soluble in organic solvents such as dimethylformamide (DMF) and dimethyl sulfoxide (DMSO). Its stability and reactivity make it valuable in solid-phase peptide synthesis, where precise control over amino acid sequences is crucial. The presence of the lysine side chain allows for additional modifications, such as conjugation with other molecules, enhancing its utility in bioconjugation and drug development. Overall, Fmoc-Lys(Dde)-OH is an important building block in the field of medicinal chemistry and peptide research.

Formula: C₃₁H₃₆N₂O₆

Synonyms:

• N(A)-fmoc-N(E)(4,4-dime.-2,6-dioxocyclo-hexylidene)et.-L-lys
• N-Fmoc-N'-[1-(4,4-Dimethyl-2,6-Dioxocyclohexylidene)Ethyl]-D-Lysine
• Fmoc-D-Lys(Dde)-OH
• Fmoc-L-Lys(Dde)-OH

Nα-[(9H-Fluoren-9-ylmethyloxy)carbonyl]-Nε-1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)ethyl-L-lysine

CAS: 150629-67-7

Formula: C₃₁H₃₆N₂O₆

Purity: min. 98.0 area%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 532.64

Ref: 3B-F1270

Fmoc-Lys(Dde)-OH

CAS: 150629-67-7

The Nε-protecting group Dde is orthogonal to both Fmoc and Boc which allows on-resin modification of lysine side chains during Fmoc/tBu-based SPPS. The applications of Dde side-chain protection include synthesis of branched or di-epitopic peptides, preparation of MAP core molecules and lipo-MAPS, the synthesis of cyclic peptides, TASP molecules, and templates for combinatorial chemistry and synthetic proteins. Dde can be cleaved by 2% hydrazine in DMF.

Formula: C₃₁H₃₆N₂O₆

Purity: 98.5%

Color and Shape: Light Yellow

Molecular weight: 532.64

Ref: 01-4027144

L-Lysine, N6-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl]-N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-

CAS: 150629-67-7

Formula: C₃₁H₃₆N₂O₆

Purity: 97%

Color and Shape: Solid

Molecular weight: 532.6273

Ref: IN-DA001MS9

Fmoc-L-Lys(Dde)-OH

CAS: 150629-67-7

Fmoc-L-Lys(Dde)-OH

Purity: 97%

Molecular weight: 532.63g/mol

Ref: 54-OR1036501

Fmoc-L-Lys(Dde)-OH

CAS: 150629-67-7

Formula: C₃₁H₃₆N₂O₆

Purity: ≥ 97.0%

Color and Shape: Off-white to light-yellow or beige powder

Molecular weight: 532.63

Ref: 7W-GM9237

N-α-Fmoc-Nε-1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)ethyl-L-lysine

CAS: 150629-67-7

N-alpha-Fmoc-Nepsilon-1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)ethyl-L-lysine is a synthetic amide with a peptide backbone. It has been shown to have anti tumor activity in vivo and in vitro against a variety of solid tumor xenografts. The compound was conjugated to the integrin receptor ligand RGD, which is expressed on the surface of various types of cancer cells. This modification increased the uptake of N-alpha-Fmoc-Nepsilon-1-(4,4 dimethyl 2,6 dioxocyclohex1 ylidene)ethyl L lysine by leukemia cells and solid tumor xenografts.

Formula: C₃₁H₃₆N₂O₆

Purity: Min. 98 Area-%

Color and Shape: Slightly Yellow Powder

Molecular weight: 532.63 g/mol

Ref: 3D-FF47763

Fmoc-Lys(Dde)-OH

CAS: 150629-67-7

M06253 - Fmoc-Lys(Dde)-OH

Formula: C₃₁H₃₆N₂O₆

Purity: 97%

Color and Shape: Solid

Molecular weight: 532.637

Ref: 10-M06253