CAS 150725-87-4

4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(3-methoxyphenoxy)pyrimidin-4-yl]benzenesulfonamide

Description:

4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(3-methoxyphenoxy)pyrimidin-4-yl]benzenesulfonamide is a chemical compound characterized by its complex structure, which includes a sulfonamide group, a pyrimidine ring, and various substituents that enhance its solubility and biological activity. The presence of the tert-butyl group contributes to its hydrophobic characteristics, while the hydroxyethoxy and methoxyphenoxy groups increase its polarity and potential for interaction with biological targets. This compound is often studied for its pharmacological properties, particularly in the context of medicinal chemistry, where it may exhibit activity against specific enzymes or receptors. Its sulfonamide moiety is known for its role in various therapeutic applications, including antibacterial and diuretic effects. The compound's solubility, stability, and reactivity can be influenced by its functional groups, making it a subject of interest in drug development and formulation. Overall, its unique structural features suggest potential utility in various biochemical applications.

Formula: C₂₃H₂₇N₃O₆S

InChI: InChI=1/C23H27N3O6S/c1-23(2,3)16-8-10-19(11-9-16)33(28,29)26-21-20(22(25-15-24-21)31-13-12-27)32-18-7-5-6-17(14-18)30-4/h5-11,14-15,27H,12-13H2,1-4H3,(H,24,25,26)

SMILES: CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1c(c(ncn1)OCCO)Oc1cccc(c1)OC

Synonyms:

• benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(3-methoxyphenoxy)-4-pyrimidinyl]-

Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(3-methoxyphenoxy)-4-pyrimidinyl]-

CAS: 150725-87-4

Formula: C₂₃H₂₇N₃O₆S

Purity: 98%

Color and Shape: Solid

Molecular weight: 473.5420

Ref: IN-DA001MTR

Ro 46-2005

CAS: 150725-87-4

Ro 46-2005

Purity: ≥95%

Molecular weight: 473.54g/mol

Ref: 54-BUP10497

Ro 46-2005

CAS: 150725-87-4

Ro 46-2005: Synthetic non-peptide, blocks 125I-ET-1 at ETA receptors on human vascular cells (IC50: 220 nM).

Formula: C₂₃H₂₇N₃O₆S

Purity: 98.02% - 98.8%

Color and Shape: Solid

Molecular weight: 473.54

Ref: TM-T3194

RO462005

CAS: 150725-87-4

RO462005 is a synthetic compound that has been shown to have physiological effects on cardiac tissues and the cardiovascular system. It binds to the receptor of the G-protein, which is coupled to a phospholipase C (PLC) cascade. RO462005 activates PLC, which leads to an increase in intracellular calcium levels and activation of protein kinase C (PKC). This activity leads to vasodilation and increased blood flow. RO462005 has been shown to inhibit transcription-polymerase chain reaction (PCR) by binding to RNA polymerase II, inhibiting transcription of messenger ribonucleic acid (mRNA). It inhibits proliferation of human colon adenocarcinoma cells (CCaco-2) in vitro by binding with high affinity to their PDE4D5 receptor. RO462005 also increases contractions in vitro in response to acetylcholine or potassium chloride by stimulating muscarinic receptors on ileal smooth muscle cells from

Formula: C₂₃H₂₇N₃O₆S

Purity: Min. 95%

Molecular weight: 473.54 g/mol

Ref: 3D-AGA72587