CAS 150756-35-7: Efletirizine

Description: Efletirizine is an antihistamine belonging to the piperazine class, primarily used for the treatment of allergic conditions such as allergic rhinitis and urticaria. It functions by selectively antagonizing the H1 histamine receptor, thereby alleviating symptoms associated with histamine release, such as itching, sneezing, and runny nose. The substance is characterized by its relatively high affinity for the H1 receptor, which contributes to its effectiveness in managing allergic responses. Efletirizine is known for its low sedative properties compared to first-generation antihistamines, making it a preferred choice for patients who require relief from allergy symptoms without significant drowsiness. Additionally, it exhibits a favorable pharmacokinetic profile, with a moderate half-life that allows for once-daily dosing. Its safety profile is generally well-tolerated, although, like all medications, it may have potential side effects. Overall, efletirizine represents a valuable option in the therapeutic management of allergic disorders.

Formula: C₂₁H₂₄F₂N₂O₃

InChI: InChI=1/C21H24F2N2O3/c22-18-5-1-16(2-6-18)21(17-3-7-19(23)8-4-17)25-11-9-24(10-12-25)13-14-28-15-20(26)27/h1-8,21H,9-15H2,(H,26,27)

Synonyms:

• Efletirizine [INN]
• (2-(4-(Bis(p-fluorophenyl)methyl)-1-piperazinyl)ethoxy)acetic acid
• Unii-B6C301298G
• (2-{4-[Bis(4-Fluorophenyl)Methyl]Piperazin-1-Yl}Ethoxy)Acetic Acid

Acetic acid, 2-[2-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]ethoxy]-

CAS: 150756-35-7

• Formula: C₂₁H₂₄F₂N₂O₃
• Purity: 95%
• Molecular weight: 390.4237

Efletirizine

CAS: 150756-35-7

Efletirizine (UCB-28754), a histamine blocker and 5-LO inhibitor, aids in topical allergy treatment.

• Formula: C₂₁H₂₄F₂N₂O₃
• Purity: 98.98%
• Color and Shape: Solid
• Molecular weight: 390.42

2-[2-[4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl]ethoxy]acetic acid hydrochloride

CAS: 150756-35-7

2-[2-[4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl]ethoxy]acetic acid hydrochloride (FPA) is a potent and selective inhibitor of the CCR5 receptor. It …

• Formula: C₂₁H₂₄F₂N₂O₃
• Purity: Min. 95%
• Molecular weight: 390.4 g/mol