CAS 150756-35-7

Efletirizine

Description:

Efletirizine is an antihistamine belonging to the piperazine class, primarily used for the treatment of allergic conditions such as allergic rhinitis and urticaria. It functions by selectively antagonizing the H1 histamine receptor, thereby alleviating symptoms associated with histamine release, such as itching, sneezing, and runny nose. The substance is characterized by its relatively high affinity for the H1 receptor, which contributes to its effectiveness in managing allergic responses. Efletirizine is known for its low sedative properties compared to first-generation antihistamines, making it a preferred choice for patients who require relief from allergy symptoms without significant drowsiness. Additionally, it exhibits a favorable pharmacokinetic profile, with a moderate half-life that allows for once-daily dosing. Its safety profile is generally well-tolerated, although, like all medications, it may have potential side effects. Overall, efletirizine represents a valuable option in the therapeutic management of allergic disorders.

Formula: C₂₁H₂₄F₂N₂O₃

InChI: InChI=1/C21H24F2N2O3/c22-18-5-1-16(2-6-18)21(17-3-7-19(23)8-4-17)25-11-9-24(10-12-25)13-14-28-15-20(26)27/h1-8,21H,9-15H2,(H,26,27)

SMILES: c1cc(ccc1C(c1ccc(cc1)F)N1CCN(CC1)CCOCC(=O)O)F

Synonyms:

• Efletirizine [INN]
• (2-(4-(Bis(p-fluorophenyl)methyl)-1-piperazinyl)ethoxy)acetic acid
• Unii-B6C301298G
• (2-{4-[Bis(4-Fluorophenyl)Methyl]Piperazin-1-Yl}Ethoxy)Acetic Acid

Acetic acid, 2-[2-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]ethoxy]-

CAS: 150756-35-7

Formula: C₂₁H₂₄F₂N₂O₃

Purity: 95%

Molecular weight: 390.4237

Ref: IN-DA001MUB

Efletirizine

CAS: 150756-35-7

Efletirizine

Purity: ≥95%

Molecular weight: 390.42g/mol

Ref: 54-BUP07990

Efletirizine

CAS: 150756-35-7

Efletirizine (UCB-28754), a histamine blocker and 5-LO inhibitor, aids in topical allergy treatment.

Formula: C₂₁H₂₄F₂N₂O₃

Purity: 99.39%

Color and Shape: Solid

Molecular weight: 390.42

Ref: TM-T27244

2-[2-[4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl]ethoxy]acetic acid hydrochloride

CAS: 150756-35-7

2-[2-[4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl]ethoxy]acetic acid hydrochloride (FPA) is a potent and selective inhibitor of the CCR5 receptor. It blocks the binding of HIV to this receptor, preventing its entry into cells. FPA can be used to study the role of CCR5 in inflammation, as well as for treating chronic inflammatory diseases such as idiopathic urticaria and other autoimmune disorders. FPA has been shown to have a linear calibration curve in pharmacokinetics studies and minimal drug interactions with other drugs. It also exhibits low toxicity in animal models, which makes it an ideal candidate for use in humans.

Formula: C₂₁H₂₄F₂N₂O₃

Purity: Min. 95%

Molecular weight: 390.4 g/mol

Ref: 3D-AGA75635