CAS 150812-12-7

Retigabine

Description:

Retigabine, also known as ezogabine, is a pharmaceutical compound primarily used as an anticonvulsant for the treatment of epilepsy. It functions as a potassium channel opener, specifically targeting the KCNQ (Kv7) family of potassium channels, which plays a crucial role in stabilizing neuronal excitability. The chemical formula of Retigabine is C12H15N3O, and it has a molecular weight of approximately 219.27 g/mol. The substance is characterized by its ability to enhance the activity of these potassium channels, leading to hyperpolarization of neurons and a reduction in excitatory neurotransmission. Retigabine is typically administered orally and is known for its unique mechanism of action compared to other antiepileptic drugs. It has a moderate solubility in water and is often formulated in various dosage forms. Side effects may include dizziness, fatigue, and urinary retention, among others. Due to its specific pharmacological profile, Retigabine has been an important option in the management of refractory epilepsy.

Formula: C₁₆H₁₈FN₃O₂

InChI: InChI=1S/C16H18FN3O2/c1-2-22-16(21)20-15-8-7-13(9-14(15)18)19-10-11-3-5-12(17)6-4-11/h3-9,19H,2,10,18H2,1H3,(H,20,21)

InChI key: InChIKey=PCOBBVZJEWWZFR-UHFFFAOYSA-N

SMILES: N(C(OCC)=O)C1=C(N)C=C(NCC2=CC=C(F)C=C2)C=C1

Synonyms:

• 2-Amino-4-(4-Fluorbenzylamino)-1-Ethoxycarbonylaminobenzene
• Carbamic acid, N-[2-amino-4-[[(4-fluorophenyl)methyl]amino]phenyl]-, ethyl ester
• Carbamic acid, [2-amino-4-[[(4-fluorophenyl)methyl]amino]phenyl]-, ethyl ester
• D 23129
• D2312
• Ethyl [2-amino-4-[[(4-fluorophenyl)methyl]amino]phenyl]carbamate
• Ethyl {2-Amino-4-[(4-Fluorobenzyl)Amino]Phenyl}Carbamate
• Ezogabine
• Gke 841
• Gw 582892X
• N-(2-Amino-4-(4-fluorobenzylamino)phenyl)carbamic Acid Ethyl Ester
• Potiga
• Retigabin
• RetigabineDiscontinued See: R189051
• Trobalt
• Way 143841
• [2-Amino-4-(4-fluoro-benzylamino)-phenyl]-carbamic acid ethyl ester

Retigabine

CAS: 150812-12-7

Formula: C₁₆H₁₈FN₃O₂

Purity: ≥ 98.0%

Color and Shape: White to light-brown powder

Molecular weight: 303.33

Ref: 7W-GP5601

Retigabine

Controlled Product

CAS: 150812-12-7

Stability Hygroscopic
Applications A new experimental anticonvulsant drug. Anxiolytic.
References Dailey, J.W.; et al.: Neuroscience Lett., 195, 77 (1995), Korsgaard, M.P.G., et al.: J. Pharmacol. Exp. Ther., 314, 1, 282 (2005),

Formula: C₁₆H₁₈FN₃O₂

Color and Shape: Neat

Molecular weight: 303.33

Ref: TR-R189050

Retigabine

Controlled Product

CAS: 150812-12-7

Retigabine is a carbamate that binds to the benzodiazepine binding site of the gamma-aminobutyric acid receptor. It has been shown to have analgesic properties in animal studies, and has also been investigated as a potential treatment for epilepsy. Retigabine may be used in combination with other drugs, such as flumazenil, which can reverse its effects. The structural analog of retigabine is flumazenil, a drug that can reverse the effects of benzodiazepines such as diazepam and midazolam. Retigabine also interacts with other drugs through significant effects on their pharmacokinetics and pharmacodynamics.

Formula: C₁₆H₁₈FN₃O₂

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 303.33 g/mol

Ref: 3D-FA61501