CAS 150812-13-8

Retigabine dihydrochloride

Description:

Retigabine dihydrochloride, also known as ezogabine, is a pharmaceutical compound primarily used as an anticonvulsant for the treatment of epilepsy. It functions as a potassium channel opener, specifically targeting the KCNQ (Kv7) family of potassium channels, which plays a crucial role in stabilizing neuronal excitability. The substance appears as a white to off-white crystalline powder and is soluble in water, making it suitable for formulation in various dosage forms. Its chemical structure includes a phenyl ring and a carbonyl group, contributing to its pharmacological activity. Retigabine dihydrochloride is administered orally and has a relatively long half-life, allowing for less frequent dosing. While effective in reducing seizure frequency, it may also cause side effects such as dizziness, fatigue, and urinary retention. Due to its unique mechanism of action, it represents a distinct therapeutic option in the management of epilepsy, particularly for patients who do not respond adequately to traditional antiepileptic drugs.

Formula: C₁₆H₂₀Cl₂FN₃O₂

InChI: InChI=1/C16H18FN3O2.ClH/c1-2-22-16(21)20-15-8-7-13(9-14(15)18)19-10-11-3-5-12(17)6-4-11;/h3-9,19H,2,10,18H2,1H3,(H,20,21);1H

InChI key: InChIKey=WSGFOWNASITQHJ-UHFFFAOYSA-N

SMILES: N(C(OCC)=O)C1=C(N)C=C(NCC2=CC=C(F)C=C2)C=C1.Cl

Synonyms:

• Carbamic acid, N-[2-amino-4-[[(4-fluorophenyl)methyl]amino]phenyl]-, ethyl ester, hydrochloride (1:2)
• Carbamic acid, [2-amino-4-[[(4-fluorophenyl)methyl]amino]phenyl]-, ethyl ester, dihydrochloride
• D 20443
• Ethyl [2-amino-4-[[(4-fluorophenyl)methyl]amino]phenyl]carbamate Dihydrochloride
• Ethyl {2-Amino-4-[(4-Fluorobenzyl)Amino]Phenyl}Carbamate Dihydrochloride
• Ethyl {2-Amino-4-[(4-Fluorobenzyl)Amino]Phenyl}Carbamate Hydrochloride
• N-(2-Amino-4-(4-fluorobenzylamino)phenyl)carbamic Acid Ethyl Ester Dihydrochloride
• Retigabine 2HCl
• Retigabine dihydrochloride
• ethyl 2-aMino-4-(4-fluorobenzylaMino)phenylcarbaMate dihydrochloride
• D-20443 dihydrochloride
• Retigabin.2HCl
• D 20443 dihydrochloride
• D20443 dihydrochloride

Retapamulin Impurity 16

CAS: 150812-13-8

Formula: C₃₀H₄₇NO₅S

Color and Shape: White To Off-White Solid

Molecular weight: 533.76

Ref: 4Z-R-101017

Retigabine (Ezogabine) DiHCl

CAS: 150812-13-8

Formula: C₁₆H₁₈FN₃O₂·2HCl

Color and Shape: White To Off-White Solid

Molecular weight: 303.34 2 36.46

Ref: 4Z-R-101

Retigabine dihydrochloride

CAS: 150812-13-8

Formula: C₁₆H₁₈FN₃O₂·2HCl

Purity: (HPLC) ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 376.25

Ref: 7W-GP0386

Retigabine Dihydrochloride

Controlled Product

CAS: 150812-13-8

Applications An experimental anticonvulsant drug. Anxiolytic.
References Dailey, J.W.; et al.: Neuroscience Lett., 195, 77 (1995), Korsgaard, M.P.G., et al.: J. Pharmacol. Exp. Ther., 314, 1, 282 (2005),

Formula: C₁₆H₁₈FN₃O₂·2ClH

Color and Shape: Neat

Molecular weight: 376.25

Ref: TR-R189051

Retigabine dihydrochloride

Controlled Product

CAS: 150812-13-8

Voltage-gated potassium channel opener

Formula: C₁₆H₂₀Cl₂FN₃O₂

Purity: Min. 95%

Color and Shape: Off-White Powder

Molecular weight: 376.25 g/mol

Ref: 3D-FR27709

Retigabine HCl - Bio-X ™

Controlled Product

CAS: 150812-13-8

Retigabine is an antiepileptic drug that works as a potassium channel opener. It activates a certain family of voltage gated channels in the brain. Its mechanism of action is chemically similar to flupirtine. Retigabine is used for the treatment of epilepsy.

Formula: C₁₆H₁₈FN₃O₂•(HCl)₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 376.25 g/mol

Ref: 3D-BR164335

Retigabine-d4 N-β-D-Glucuronide

Controlled Product

CAS: 150812-13-8

Applications Labelled Retigabine N-β-D-Glucuronide, the major metabolite of the antiepileptic drug Retigabine (R189050) that is produced via N-glucuronidation in humans.
References Hiller, A. et al.: Drug Metab. Dispos., 27, 605 (1999); Borlak, J. et al.: Metab. Clin. Exp., 55, 711 (2006); McNeilly, P.P. et al.: Zenobiotica, 27, 431 (1997);

Formula: C₂₂D₄H₂₂FN₃O₈

Color and Shape: Neat

Molecular weight: 483.48

Ref: TR-R189062