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CAS 151038-96-9

:

DOXO-EMCH

Description:
DOXO-EMCH, with the CAS number 151038-96-9, is a chemical compound that serves as a prodrug of doxorubicin, a well-known chemotherapeutic agent. This compound is characterized by its ability to selectively release doxorubicin in targeted tissues, enhancing the drug's therapeutic efficacy while minimizing systemic toxicity. DOXO-EMCH is typically designed to improve the pharmacokinetics and biodistribution of doxorubicin, allowing for more effective cancer treatment. The structure of DOXO-EMCH includes a linker that facilitates the release of doxorubicin upon enzymatic cleavage, which is often mediated by specific enzymes present in the tumor microenvironment. This targeted approach aims to increase the concentration of the active drug at the tumor site, thereby improving the overall treatment outcome. Additionally, the compound's solubility, stability, and metabolic profile are crucial for its performance in clinical settings. As research continues, DOXO-EMCH represents a promising avenue in the development of more effective cancer therapies with reduced side effects.
Formula:C37H42N4O13
InChI:InChI=1/C37H42N4O13/c1-17-32(46)20(38)13-27(53-17)54-22-15-37(51,23(16-42)39-40-24(43)9-4-3-5-12-41-25(44)10-11-26(41)45)14-19-29(22)36(50)31-30(34(19)48)33(47)18-7-6-8-21(52-2)28(18)35(31)49/h6-8,10-11,17,20,22,27,32,42,46,48,50-51H,3-5,9,12-16,38H2,1-2H3,(H,40,43)/b39-23+
InChI key:InChIKey=OBMJQRLIQQTJLR-FRTGXRTISA-N
SMILES:OC=1C2=C([C@@H](O[C@H]3C[C@H](N)[C@H](O)[C@H](C)O3)C[C@@](C(=NNC(CCCCCN4C(=O)C=CC4=O)=O)CO)(O)C2)C(O)=C5C1C(=O)C=6C(C5=O)=C(OC)C=CC6
Synonyms:
  • 1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo-, (1-(4-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl)-2-hydroxyethylidene)hydrazide, (2S-cis)-
  • 1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo-, 2-[1-[(2S,4S)-4-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]-2-hydroxyethylidene]hydrazide
  • 1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo-, [1-[(2S,4S)-4-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]-2-hydroxyethylidene]hydrazide
  • 1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo-, [1-[4-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]-2-hydroxyethylidene]hydrazide, (2S-cis)-
  • 2,5-Dihydro-2,5-dioxo-1H-pyrrole-1-hexanoic acid (1-(4-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl)-2-hydroxyethylidene)hydrazide, (2S-cis)-
  • Aldoxorubicin
  • Doxo-Emch
  • Doxorubicin-EMCH
  • MC-Doxhzn
  • N'-[(1E)-1-{4-[(3-amino-2,3,6-trideoxyhexopyranosyl)oxy]-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-2-yl}-2-hydroxyethylidene]-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide
  • See more synonyms
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Found 4 products.
  • DOXO-EMCH
    Indagoo
    + Info

    DOXO-EMCH

    CAS:
    Formula:C37H42N4O13
    Molecular weight:750.7484

    Ref: IN-DA001N0W

    ne
    To inquire
  • Doxorubicin-hydrazone-caproyl-maleimide
    TRC
    + Info

    Doxorubicin-hydrazone-caproyl-maleimide

    Controlled Product
    CAS:
    Formula:C37H42N4O13
    Color and Shape:Neat
    Molecular weight:750.75

    Ref: TR-D558040

    1mg
    346.00€
    5mg
    1,477.00€
  • Doxorubicin-hydrazone-caproyl-maleimide
    Biosynth
    + Info

    Doxorubicin-hydrazone-caproyl-maleimide

    CAS:
    <p>a 6-maleimidocaproyl hydrazone derivative of Doxorubicin which is an albumin binding prodrug.  It is acid sensitive and selectively binds to the cysteine-34 position of circulating albumin.</p>
    Formula:C37H42N4O13
    Purity:Min. 95%
    Color and Shape:Powder
    Molecular weight:750.75 g/mol

    Ref: 3D-BGA03896

    5mg
    863.00€
  • MC-DOXHZN
    Targetmol
    + Info

    MC-DOXHZN

    CAS:
    Mc-doxhzn is a protein-binding prodrug of DOXUbicin (DNA topoisomerase II inhibitor) with acid sensitivity.
    Formula:C37H42N4O13
    Purity:98%
    Color and Shape:Solid
    Molecular weight:750.75

    Ref: TM-T11090

    25mg
    1,444.00€