CAS 151038-96-9: DOXO-EMCH

Description: DOXO-EMCH, with the CAS number 151038-96-9, is a chemical compound that serves as a prodrug of doxorubicin, a well-known chemotherapeutic agent. This compound is characterized by its ability to selectively release doxorubicin in targeted tissues, enhancing the drug's therapeutic efficacy while minimizing systemic toxicity. DOXO-EMCH is typically designed to improve the pharmacokinetics and biodistribution of doxorubicin, allowing for more effective cancer treatment. The structure of DOXO-EMCH includes a linker that facilitates the release of doxorubicin upon enzymatic cleavage, which is often mediated by specific enzymes present in the tumor microenvironment. This targeted approach aims to increase the concentration of the active drug at the tumor site, thereby improving the overall treatment outcome. Additionally, the compound's solubility, stability, and metabolic profile are crucial for its performance in clinical settings. As research continues, DOXO-EMCH represents a promising avenue in the development of more effective cancer therapies with reduced side effects.

Formula: C₃₇H₄₂N₄O₁₃

InChI: InChI=1S/C37H42N4O13/c1-17-32(46)20(38)13-27(53-17)54-22-15-37(51,23(16-42)39-40-24(43)9-4-3-5-12-41-25(44)10-11-26(41)45)14-19-29(22)36(50)31-30(34(19)48)33(47)18-7-6-8-21(52-2)28(18)35(31)49/h6-8,10-11,17,20,22,27,32,42,46,48,50-51H,3-5,9,12-16,38H2,1-2H3,(H,40,43)/t17-,20-,22-,27-,32+,37-/m0/s1

InChI key: InChIKey=OBMJQRLIQQTJLR-FRTGXRTISA-N

SMILES: O=C1C=2C=CC=C(OC)C2C(=O)C=3C(O)=C4C(=C(O)C13)CC(O)(C(=NNC(=O)CCCCCN5C(=O)C=CC5=O)CO)CC4OC6OC(C)C(O)C(N)C6

Synonyms:

• 1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo-, (1-(4-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl)-2-hydroxyethylidene)hydrazide, (2S-cis)-
• 1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo-, 2-[1-[(2S,4S)-4-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]-2-hydroxyethylidene]hydrazide
• 1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo-, [1-[(2S,4S)-4-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]-2-hydroxyethylidene]hydrazide
• 1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo-, [1-[4-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]-2-hydroxyethylidene]hydrazide, (2S-cis)-
• 2,5-Dihydro-2,5-dioxo-1H-pyrrole-1-hexanoic acid (1-(4-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl)-2-hydroxyethylidene)hydrazide, (2S-cis)-
• Aldoxorubicin
• Doxo-Emch
• Doxorubicin-EMCH
• MC-Doxhzn
• N'-[(1E)-1-{4-[(3-amino-2,3,6-trideoxyhexopyranosyl)oxy]-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-2-yl}-2-hydroxyethylidene]-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide
• 1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo-, 2-[1-[(2S,4S)-4-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]-2-hydroxyethylidene]hydrazide
• 1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo-, [1-[(2S,4S)-4-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]-2-hydroxyethylidene]hydrazide
• 1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo-, [1-[4-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]-2-hydroxyethylidene]hydrazide, (2S-cis)-
• Doxorubicin(6-maleimidocaproyl)hydrazone

1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo-, 2-[1-[(2S,4S)-4-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]-2-hydroxyethylidene]hydrazide

CAS: 151038-96-9

• Formula: C₃₇H₄₂N₄O₁₃
• Molecular weight: 750.7484

Doxorubicin-hydrazone-caproyl-maleimide

CAS: 151038-96-9

• Formula: C₃₇H₄₂N₄O₁₃
• Color and Shape: Neat
• Molecular weight: 750.75

Doxorubicin-hydrazone-caproyl-maleimide

CAS: 151038-96-9

a 6-maleimidocaproyl hydrazone derivative of Doxorubicin which is an albumin binding prodrug. It is acid …

• Formula: C₃₇H₄₂N₄O₁₃
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 750.75 g/mol

MC-DOXHZN

CAS: 151038-96-9

Mc-doxhzn is a protein-binding prodrug of DOXUbicin (DNA topoisomerase II inhibitor) with acid sensitivity.

• Formula: C₃₇H₄₂N₄O₁₃
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 750.75