Rifamycin sodium is an antibiotic compound primarily used in the treatment of bacterial infections, particularly those caused by Mycobacterium tuberculosis. It is a semi-synthetic derivative of rifamycin, which is derived from the bacterium Amycolatopsis rifamycinica. This substance exhibits broad-spectrum antibacterial activity by inhibiting bacterial RNA synthesis through binding to the DNA-dependent RNA polymerase enzyme. Rifamycin sodium is typically administered in its sodium salt form to enhance solubility and bioavailability. It is characterized by its orange-red color and is often used in combination therapies to prevent the development of drug resistance. The compound is generally well-tolerated, although it may cause side effects such as gastrointestinal disturbances and liver enzyme elevations. Due to its potent activity against resistant strains of bacteria, rifamycin sodium plays a crucial role in tuberculosis treatment regimens, particularly in multidrug-resistant cases. Its pharmacokinetics involve rapid absorption and extensive metabolism, necessitating careful monitoring during therapy to ensure efficacy and minimize adverse effects.

Rifamycin sodium

15105-92-7: Rifamycin sodium is an antibiotic compound primarily used in the treatment of bacterial infections, particularly those caused by Mycobacterium tuberculosis. It is a semi-synthetic derivative of rifamycin, which is derived from the bacterium Amycolatopsis rifamycinica. This substance exhibits broad-spectrum antibacterial activity by inhibiting bacterial RNA synthesis through binding to the DNA-dependent RNA polymerase enzyme. Rifamycin sodium is typically administered in its sodium salt form to enhance solubility and bioavailability. It is characterized by its orange-red color and is often used in combination therapies to prevent the development of drug resistance. The compound is generally well-tolerated, although it may cause side effects such as gastrointestinal disturbances and liver enzyme elevations. Due to its potent activity against resistant strains of bacteria, rifamycin sodium plays a crucial role in tuberculosis treatment regimens, particularly in multidrug-resistant cases. Its pharmacokinetics involve rapid absorption and extensive metabolism, necessitating careful monitoring during therapy to ensure efficacy and minimize adverse effects.

Rifamycin SV: a natural antibiotic inhibiting RNA polymerase, reducing ß2m aggregation, and halting bacterial protein synthesis.

CAS 15105-92-7

Rifamycin sodium

Rifamycin SV

Ref: TM-T28538