CAS 151103-08-1

4-Difluoromethoxy-3-hydroxybenzaldehyde

Description:

4-Difluoromethoxy-3-hydroxybenzaldehyde is an organic compound characterized by the presence of a benzaldehyde functional group, a hydroxy group, and a difluoromethoxy substituent. Its molecular structure features a benzene ring with a hydroxyl (-OH) group positioned at the meta position relative to the aldehyde (-CHO) group, and a difluoromethoxy (-O-CHF2) group at the para position. This compound is notable for its potential applications in medicinal chemistry and as an intermediate in organic synthesis due to the presence of both electron-withdrawing and electron-donating groups, which can influence its reactivity and interaction with biological targets. The difluoromethoxy group enhances lipophilicity and may improve the compound's pharmacokinetic properties. Additionally, the hydroxy group can participate in hydrogen bonding, affecting solubility and reactivity. Overall, 4-Difluoromethoxy-3-hydroxybenzaldehyde is a versatile compound with interesting chemical properties that warrant further investigation in various fields of research.

Formula: C₈H₆F₂O₃

InChI: InChI=1/C8H6F2O3/c9-8(10)13-7-2-1-5(4-11)3-6(7)12/h1-4,8,12H

SMILES: c1cc(c(cc1C=O)O)OC(F)F

Synonyms:

• 3-Hydroxy-4-diflouromethylbenzaldehyde
• Bromo(Difluoro)Methane
• Roflumilast intermediates-3
• 4-(difluoromethoxy)-3-hydroxybenzaldehyde

4-(Difluoromethoxy)-3-hydroxybenzaldehyde

CAS: 151103-08-1

Formula: C₈H₆F₂O₃

Purity: >98.0%(GC)

Color and Shape: White to Orange to Green powder to crystal

Molecular weight: 188.13

Ref: 3B-D4505

Benzaldehyde, 4-(difluoromethoxy)-3-hydroxy-

CAS: 151103-08-1

Formula: C₈H₆F₂O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 188.1282

Ref: IN-DA001N30

4-(Difluoromethoxy)-3-hydroxybenzaldehyde

CAS: 151103-08-1

4-(Difluoromethoxy)-3-hydroxybenzaldehyde

Formula: C₈H₆F₂O₃

Purity: 98%

Color and Shape: off white to faint brown crystalline solid

Molecular weight: 188.13g/mol

Ref: 54-PC8950

4-Difluoromethoxy-3-hydroxybenzaldehyde

CAS: 151103-08-1

Formula: C₈H₆F₂O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 188.13

Ref: 10-F021860

4-(Difluoromethoxy)-3-hydroxybenzaldehyde

Controlled Product

CAS: 151103-08-1

Applications A phenyl alkyl ketone derivative used in the preparation of phosphodiesterase-4 (PDE4) inhibitors.
References Zheng, S. et al.: J. Med. Chem., 51, 7673 (2008);

Formula: C₈H₆F₂O₃

Color and Shape: Neat

Molecular weight: 188.13

Ref: TR-D446005