CAS 151126-32-8
:Pramlintide
Description:
Pramlintide is a synthetic analog of human amylin, a peptide hormone co-secreted with insulin by pancreatic beta cells. It is primarily used as an adjunct treatment for type 1 and type 2 diabetes to improve glycemic control. Pramlintide has a molecular formula that reflects its peptide structure, and it is characterized by its ability to slow gastric emptying, reduce postprandial glucagon secretion, and promote satiety, which collectively help in managing blood glucose levels. The substance is administered via subcutaneous injection and is typically used in conjunction with insulin therapy. Its pharmacokinetics involve a relatively short half-life, necessitating multiple daily doses. Pramlintide's efficacy is supported by clinical studies demonstrating its role in reducing HbA1c levels and aiding in weight management for diabetic patients. As with any medication, it may have side effects, including nausea and hypoglycemia, particularly when used with insulin. Overall, pramlintide represents a valuable therapeutic option in diabetes management, particularly for patients who struggle with postprandial glucose control.
Formula:C171H267N51O53S2
InChI:InChI=1/C171H269N51O53S2/c1-21-81(12)130(163(268)207-110(56-78(6)7)169(274)222-53-33-42-118(222)170(275)221-52-32-41-117(221)160(265)219-135(89(20)230)167(272)206-109(66-125(180)238)151(256)212-128(79(8)9)161(266)186-68-126(239)192-111(70-223)154(259)203-107(64-123(178)236)152(257)218-134(88(19)229)166(271)195-98(136(181)241)57-92-43-45-94(231)46-44-92)214-159(264)116-40-31-51-220(116)127(240)69-187-141(246)101(58-90-34-24-22-25-35-90)199-148(253)105(62-121(176)234)201-149(254)106(63-122(177)235)202-155(260)112(71-224)209-156(261)113(72-225)208-146(251)103(60-93-67-184-75-188-93)205-162(267)129(80(10)11)213-150(255)100(55-77(4)5)198-145(250)102(59-91-36-26-23-27-37-91)200-147(252)104(61-120(175)233)196-137(242)82(13)189-144(249)99(54-76(2)3)197-142(247)96(39-30-50-185-171(182)183)193-143(248)97(47-48-119(174)232)194-165(270)132(86(17)227)215-138(243)83(14)190-157(262)114(73-276)211-168(273)133(87(18)228)216-139(244)84(15)191-164(269)131(85(16)226)217-153(258)108(65-124(179)237)204-158(263)115(74-277)210-140(245)95(173)38-28-29-49-172/h22-27,34-37,43-46,67,75-89,95-118,128-135,223-231,276-277H,21,28-33,38-42,47-66,68-74,172-173H2,1-20H3,(H2,174,232)(H2,175,233)(H2,176,234)(H2,177,235)(H2,178,236)(H2,179,237)(H2,180,238)(H2,181,241)(H,184,188)(H,186,266)(H,187,246)(H,189,249)(H,190,262)(H,191,269)(H,192,239)(H,193,248)(H,194,270)(H,195,271)(H,196,242)(H,197,247)(H,198,250)(H,199,253)(H,200,252)(H,201,254)(H,202,260)(H,203,259)(H,204,263)(H,205,267)(H,206,272)(H,207,268)(H,208,251)(H,209,261)(H,210,245)(H,211,273)(H,212,256)(H,213,255)(H,214,264)(H,215,243)(H,216,244)(H,217,258)(H,218,257)(H,219,265)(H4,182,183,185)/t81-,82-,83-,84-,85+,86+,87+,88+,89+,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,128-,129-,130-,131-,132-,133-,134-,135-/m0/s1
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Found 5 products.
L-Tyrosinamide, L-lysyl-L-cysteinyl-L-asparaginyl-L-threonyl-L-alanyl-L-threonyl-L-cysteinyl-L-alanyl-L-threonyl-L-glutaminyl-L-arginyl-L-leucyl-L-alanyl-L-asparaginyl-L-phenylalanyl-L-leucyl-L-valyl-L-histidyl-L-seryl-L-seryl-L-asparaginyl-L-asparaginyl-L-phenylalanylglycyl-L-prolyl-L-isoleucyl-L-leucyl-L-prolyl-L-prolyl-L-threonyl-L-asparaginyl-L-valylglycyl-L-seryl-L-asparaginyl-L-threonyl-, cyclic (2→7)-disulfide
CAS:Formula:C171H267N51O53S2Purity:98%Color and Shape:SolidMolecular weight:3949.3896Pramlintide
CAS:<p>Pramlintide, a polypeptide analog of human amylin, is an antidiabetic agent with antineoplastic properties in colorectal cancer.</p>Color and Shape:SolidPramlintide-d3 Trifluoroacetate
CAS:Formula:C171H264D3N51O53S2·C2HF3O2Molecular weight:2812.39 1140.02Pramlintide
CAS:<p>Pramlintide is a synthetic analog for amylin pancreatic peptide that has been used for the treatment of Type I and Type II Diabetes as a tool for glycemic control, stimulating glucose production and reducing appetite. This product has disulfide bonds between Cys2 and Cys7 and is available in the trifluoroacetate salt form.</p>Formula:C171H267N51O53S2Purity:Min. 95%Molecular weight:3,949.47 g/molPramlintide-d3 Trifluoroacetate
CAS:Controlled Product<p>Applications Pramlintide-d3 is labelled Pramlintide (P700800) which is an analogue of human amylin used in the treatment of insulin dependent diabetes.<br>References Young, A.A. et al.: Drug Dev. Res., 37, 231 (1996); Colburn, W.A. et al.: J. Clin. Pharmacol., 36, 13 (1996); Kolterman, O.G. et al.: Diabetologia, 39, 492 (1996);<br></p>Formula:C171H264D3N51O53S2xC2HF3O2Color and Shape:NeatMolecular weight:3952.41 (free base)
