CAS 151140-96-4

1-[3-[3-[4-(5-methoxypyrimidin-4-yl)piperazin-1-yl]propyl]-1H-indol-5-yl]-N-methyl-methanesulfonamide

Description:

1-[3-[3-[4-(5-methoxypyrimidin-4-yl)piperazin-1-yl]propyl]-1H-indol-5-yl]-N-methyl-methanesulfonamide, with CAS number 151140-96-4, is a synthetic organic compound characterized by its complex structure, which includes an indole moiety, a piperazine ring, and a methanesulfonamide group. This compound exhibits properties typical of small-molecule pharmaceuticals, including potential bioactivity due to its ability to interact with biological targets. The presence of the methoxypyrimidine and piperazine components suggests possible applications in medicinal chemistry, particularly in the development of drugs targeting neurological or psychiatric disorders. Its solubility and stability can vary based on environmental conditions, such as pH and temperature, which are crucial for its formulation and delivery in therapeutic contexts. Additionally, the compound's pharmacokinetic properties, including absorption, distribution, metabolism, and excretion (ADME), would be essential for evaluating its efficacy and safety in clinical settings. Overall, this compound represents a significant interest in drug discovery and development.

Formula: C₂₂H₃₀N₆O₃S

InChI: InChI=1/C22H30N6O3S/c1-23-32(29,30)15-17-5-6-20-19(12-17)18(13-25-20)4-3-7-27-8-10-28(11-9-27)22-21(31-2)14-24-16-26-22/h5-6,12-14,16,23,25H,3-4,7-11,15H2,1-2H3

InChI key: InChIKey=WRZVGHXUPBWIOO-UHFFFAOYSA-N

SMILES: C(CCN1CCN(CC1)C=2C(OC)=CN=CN2)C=3C=4C(NC3)=CC=C(CS(NC)(=O)=O)C4

Synonyms:

• 1-(3-{3-[4-(5-methoxypyrimidin-4-yl)piperazin-1-yl]propyl}-1H-indol-5-yl)-N-methylmethanesulfonamide
• 1H-Indole-5-methanesulfonamide, 3-(3-(4-(5-methoxy-4-pyrimidinyl)-1-piperazinyl)propyl)-N-methyl-
• 3-(3-(4-(5-Methoxy-4-pyrimidinyl)-1-piperazinyl)propyl)-N-methylindole-5-methanesulfonamide
• 3-[3-[4-(5-Methoxy-4-pyrimidinyl)-1-piperazinyl]propyl]-N-methyl-1H-indole-5-methanesulfonamide
• Avitriptan
• Avitriptan [INN]
• Unii-6Rs056L04P
• 1-[3-[3-[4-(5-methoxypyrimidin-4-yl)piperazin-1-yl]propyl]-1H-indol-5-yl]-N-methyl-methanesulfonamide
• Avitriptan D8

1H-Indole-5-methanesulfonamide, 3-[3-[4-(5-methoxy-4-pyrimidinyl)-1-piperazinyl]propyl]-N-methyl-

CAS: 151140-96-4

Formula: C₂₂H₃₀N₆O₃S

Molecular weight: 458.577

Ref: IN-DA001N4I

Avitriptan

CAS: 151140-96-4

Formula: C₂₂H₃₀N₆O₃S

Molecular weight: 458.58

Ref: 4Z-A-176001

Avitriptan

CAS: 151140-96-4

Avitriptan is used to treat migraine headaches, as well as other types of headaches. It belongs to the category of anti-migraine drugs and is available in oral, injectable, nasal spray, and suppository forms. Avitriptan binds selectively to neurokinin-1 (NK1) receptors on the trigeminal nerve endings in the brain that are responsible for pain transmission. This drug has shown clinical relevance in treating coronary heart diseases and reducing blood pressure levels. There have been a number of clinical studies that have demonstrated its effectiveness in treating migraine headaches. The concentration-response curve for avitriptan has been found to be dose-dependent, with a plateau at doses greater than 100 mg.

Purity: Min. 95%

Ref: 3D-FM176232

Avitriptan

CAS: 151140-96-4

Formula: C₂₂H₃₀N₆O₃S

Molecular weight: 458.58

Ref: ST-EA-CP-A320000