CAS 151319-34-5
:Zaleplon
Description:
Zaleplon is a non-benzodiazepine hypnotic agent primarily used for the treatment of insomnia. It belongs to the class of medications known as sedative-hypnotics and is characterized by its rapid onset of action and relatively short half-life, making it effective for individuals who have difficulty falling asleep. The chemical structure of zaleplon features a pyrazolopyrimidine core, which contributes to its pharmacological properties. It acts as a selective agonist at the benzodiazepine site of the GABA-A receptor, enhancing the inhibitory effects of gamma-aminobutyric acid (GABA) in the central nervous system. This mechanism results in sedative effects, promoting sleep initiation. Zaleplon is generally well-tolerated, with a lower risk of dependence compared to traditional benzodiazepines, although it may still cause side effects such as dizziness, headache, and potential next-day sedation. Due to its short duration of action, it is particularly useful for treating sleep-onset insomnia rather than maintaining sleep. As with any medication, it is important to use zaleplon under the guidance of a healthcare professional.
Formula:C17H15N5O
InChI:InChI=1S/C17H15N5O/c1-3-21(12(2)23)15-6-4-5-13(9-15)16-7-8-19-17-14(10-18)11-20-22(16)17/h4-9,11H,3H2,1-2H3
InChI key:InChIKey=HUNXMJYCHXQEGX-UHFFFAOYSA-N
SMILES:C(#N)C1=C2N(C(=CC=N2)C3=CC(N(C(C)=O)CC)=CC=C3)N=C1
Synonyms:- Cl 284846
- L 846
- Ljc 10846
- N-[3-(3-Cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamide
- Pyrazolo[1,5-a]pyrimidine, acetamide deriv.
- Siesta
- Sonata
- Zaleplon
- Zerene
- Acetamide, N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethyl-
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Found 10 products.
Zaleplon
CAS:Controlled Product<p>Applications Selective non-benzodiazepine GABAA receptor agonist.<br>References Allen, D., et al.: Eur. J. Clin. Pharmacol., 45, 313 (1993), Beer, B., et al.: J. Clin. Pharmacol., 34, 335 (1994), Rosen, A.S., et al.: Biopharm. Drug Dispos., 20, 171 (1999), Elie, R., et al.: J. Clin. Psychiatry, 60, 536 (1999), Heydorn, W.E., et al.: Expert Opin. Invest. Drugs, 9, 841 (2000)<br></p>Formula:C17H15N5OColor and Shape:Off-WhiteMolecular weight:305.33Zaleplon
CAS:Controlled Product<p>Zaleplon is a ligand that binds to the GABA-A receptor, which is an ion channel that regulates the flow of chloride ions into neurons. This inhibition prevents the flow of chloride ions and reduces neuronal activity, leading to sedation. Zaleplon has been shown to have an affinity for the alpha 1 subunit of the GABA-A receptor and inhibitory effects on receptors in rat brain tissue. It has also been shown to be a highly selective inhibitor of peptide ligand binding with high purity. Zaleplon is used as a research tool in cell biology and pharmacology, as well as an antibody or protein interactions. It can be used as an anti-anxiety agent, but should not be taken by pregnant women or people driving or operating machinery due to its potential side effects.</p>Formula:C17H15N5OPurity:Min. 98 Area-%Molecular weight:305.33 g/molZaleplon CIV
CAS:Controlled ProductDrugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structureFormula:C17H15N5OColor and Shape:PowderMolecular weight:305.12766
