CAS 1514889-12-3
:Immunoglobulin G1, anti-(human guanylate cyclase isoenzyme C) (human monoclonal 5F9 γ1-chain), disulfide with human monoclonal 5F9 κ-chain, dimer, tetrakis(thioether) with N-[[[4-[[N-[6-(3-mercapto-2,5-dioxo-1-pyrrolidinyl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-L-ornithyl]amino]phenyl]methoxy]carbonyl]-N-methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide
Description:
Immunoglobulin G1 (IgG1) is a type of antibody that plays a crucial role in the immune response, specifically targeting antigens such as proteins and pathogens. The specific compound mentioned, anti-(human guanylate cyclase isoenzyme C) (human monoclonal 5F9 γ1-chain), is a monoclonal antibody designed to bind to human guanylate cyclase C, which is involved in various physiological processes, including fluid and electrolyte balance. This antibody is characterized by its dimeric structure, formed through disulfide linkages between the γ1 and κ chains, enhancing its stability and functionality. The presence of tetrakis(thioether) indicates the incorporation of sulfur-containing groups, which may contribute to the compound's overall stability and solubility. The complex structure also includes various amino acid modifications, suggesting a tailored design for improved binding affinity and specificity. Overall, this compound exemplifies the intricate design of therapeutic antibodies, combining biological activity with chemical modifications to enhance therapeutic efficacy in clinical applications.
Formula:Unspecified
Synonyms:- Indusatumab vedotin
- Immunoglobulin G1, anti-(human guanylate cyclase isoenzyme C) (human monoclonal 5F9 γ1-chain), disulfide with human monoclonal 5F9 κ-chain, dimer, tetrakis(thioether) with N-[[[4-[[N-[6-(3-mercapto-2,5-dioxo-1-pyrrolidinyl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-L-ornithyl]amino]phenyl]methoxy]carbonyl]-N-methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide
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Found 2 products.
Indusatumab vedotin
CAS:Indusatumab vedotin (MLN-0264; AKT-264) is an antibody-drug conjugate (ADC) that combines a human anti-guanylate cyclase C (GCC) antibody with the microtubule-disruptor monomethyl auristatin E, demonstrating anti-proliferative effects on pancreatic cancer cell lines by arresting the cell cycle at the G2/M phase and inducing apoptosis [1].Color and Shape:Liquid
