CAS 151519-50-5

Rapamycin, 7-O-demethyl-

Description:

Rapamycin, 7-O-demethyl- is a derivative of the macrolide antibiotic rapamycin, which is produced by the bacterium Streptomyces hygroscopicus. This compound is known for its immunosuppressive and anti-proliferative properties, making it significant in both medical and research applications. It functions primarily as an inhibitor of the mTOR (mechanistic target of rapamycin) pathway, which plays a crucial role in cell growth, proliferation, and survival. The chemical structure of 7-O-demethyl-rapamycin features a modified lactone ring, which alters its biological activity compared to its parent compound. This modification can influence its solubility, stability, and interaction with biological targets. The substance is often studied for its potential therapeutic applications in cancer treatment, organ transplantation, and age-related diseases. Additionally, it has garnered interest in the field of pharmacology for its role in modulating immune responses and its potential effects on longevity. As with many compounds, safety and efficacy are critical considerations in its use, necessitating thorough research and clinical evaluation.

7-O-Demethyl Rapamycin

CAS: 151519-50-5

Formula: C₅₀H₇₇NO₁₃

Purity: ≥ 80.0%

Color and Shape: White to off-white solid

Molecular weight: 900.15

Ref: 7W-GX9943

7-O-Demethyl rapamycin

CAS: 151519-50-5

Novolimus is a macrocyclic lactone with anti-proliferative properties. It has similar efficacy to currently available agents but requires a lower dose.

Formula: C₅₀H₇₇NO₁₃

Color and Shape: Solid

Molecular weight: 900.16

Ref: TM-T25882

7-O-Demethyl Rapamycin

CAS: 151519-50-5

Formula: C₅₀H₇₇NO₁₃

Molecular weight: 900.17

Ref: 4Z-R-1816

7-O-Demethyl Rapamycin (~80%)

CAS: 151519-50-5

Applications Rapamycin metabolite.
References Dickman, D., et al.: Bioorg. Med. Chem. Lett., 10, 1405 (2000), Davis, D., et al.: Clin. Biochem., 33, 31 (2000), Cummins, C., et al.: J. Pharmacol. Exper. Ther., 308, 143 (2004), Scholer, A., et al.: Clin. Lab., 52, 325 (2006),

Formula: C₅₀H₇₇NO₁₃

Purity: ~80%

Color and Shape: Neat

Molecular weight: 900.15

Ref: TR-D231240

7-O-Demethyl rapamycin

CAS: 151519-50-5

7-O-Demethyl rapamycin is a macrolide compound, which is a derivative of rapamycin, originally sourced from the bacterial species *Streptomyces hygroscopicus*. This compound operates by binding to the FK506-binding protein 12 (FKBP12), forming a complex that inhibits the mammalian target of rapamycin (mTOR) pathway. This inhibition interferes with cellular processes such as cell growth, proliferation, and survival by altering the phosphorylation state of downstream targets.

Formula: C₅₀H₇₇NO₁₃

Purity: 80%Min

Molecular weight: 900.15 g/mol

Ref: 3D-AD21012

7-O-Demethyl Rapamycin

CAS: 151519-50-5

Formula: C₅₀H₇₇NO₁₃

Molecular weight: 900.16

Ref: ST-EA-CP-R26004