CAS 15183-37-6

Estetrol

Description:

Estetrol is a synthetic estrogen that is primarily used in hormonal therapies, particularly in contraceptives and hormone replacement therapies. It is characterized by its unique structure, which includes a hydroxyl group that contributes to its estrogenic activity. Estetrol is notable for its relatively mild estrogenic effects compared to other synthetic estrogens, making it a subject of interest for developing therapies with fewer side effects. Its pharmacokinetic profile indicates that it has a favorable absorption and metabolism, leading to a lower risk of thromboembolic events compared to traditional estrogens. Additionally, Estetrol exhibits a selective action on estrogen receptors, which may provide therapeutic benefits while minimizing adverse effects. The substance is typically administered orally and is recognized for its potential in improving women's health, particularly in managing menopausal symptoms and providing contraceptive options. As research continues, Estetrol's safety and efficacy profile is being evaluated to better understand its role in modern medicine.

Formula: C₁₈H₂₄O₄

InChI: InChI=1S/C18H24O4/c1-18-7-6-12-11-5-3-10(19)8-9(11)2-4-13(12)14(18)15(20)16(21)17(18)22/h3,5,8,12-17,19-22H,2,4,6-7H2,1H3/t12-,13-,14-,15-,16-,17+,18+/m1/s1

InChI key: InChIKey=AJIPIJNNOJSSQC-NYLIRDPKSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@](C=4C(CC3)=CC(O)=CC4)(CC1)[H])[H])([C@@H](O)[C@@H](O)[C@@H]2O)[H]

Synonyms:

• (15Alpha,16Alpha,17Beta)-Estra-1,3,5(10)-Triene-3,15,16,17-Tetrol
• (15a,16a,17)-Estra-1,3,5(10)-triene-3,15,16,17-tetrol
• (15α,16α,17β)-Estra-1,3,5(10)-triene-3,15,16,17-tetrol
• 1,3,5(10)-Estratrien-3,15-Alpha, 16-Alpha, 17-Beta-Tetrol
• 15-Alpha-Hydroxyestriol
• 15a-Hydroxyestriol
• 3,15a,16a,17-Tetrahydroxyestra-1,3,5(10)-triene
• 3,15α,16α,17β-Tetrahydroxyestra-1,3,5(10)-triene
• E 4
• Enb 39R14Vf
• Estra-1,3,5(10)-trien-3,15α,16α,17β-tetraol
• Estra-1,3,5(10)-triene-3,15,16,17-tetrol, (15α,16α,17β)-
• Estra-1,3,5(10)-triene-3,15a,16a,17-tetrol
• Estra-1,3,5(10)-triene-3,15α,16α,17β-tetrol

Estetrol

CAS: 15183-37-6

Formula: C₁₈H₂₄O₄

Purity: 97%

Color and Shape: Solid

Molecular weight: 304.3808

Ref: IN-DA007WTK

Estetrol

CAS: 15183-37-6

Estetrol (Donesta), a fetal liver-synthesized estrogen, selectively modulates estrogen receptors and may ease menopausal symptoms.

Formula: C₁₈H₂₄O₄

Purity: 99.93%

Color and Shape: Solid

Molecular weight: 304.38

Ref: TM-T15248

Estetrol

CAS: 15183-37-6

Estetrol

Purity: ≥98%

Molecular weight: 304.38g/mol

Ref: 54-BUP04375

Estetrol

CAS: 15183-37-6

Formula: C₁₈H₂₄O₄

Color and Shape: White To Off-White Solid

Molecular weight: 304.39

Ref: 4Z-E-100001

Estetrol-d3

CAS: 15183-37-6

Formula: C₁₈H₂₁D₃O₄

Molecular weight: 307.40

Ref: 4Z-E-100002

Estetrol-d4 (Major)

Controlled Product

CAS: 15183-37-6

Applications A labelled metabolite of Estradiol. It is an estrogenic steroid synthesized exclusively by the fetal liver during human pregnancy and reaching the maternal circulation through the placenta.
References Gurpide, E., et al.: J. Clin. Endocrinol., 26, 1355 (1966), Hagen, A., et al.: J. Clin. Endocrinol., 30, 763 (1970), Schollberg, K., et al.: Exp. Clin. Endocrinol., 85, 204 (1985), Coelingh Bennink, H., et al.: Contraception, 77, 186 (2008),

Formula: C₁₈H₂₀D₄O₄

Color and Shape: White To Off-White

Molecular weight: 308.41

Ref: TR-E668452

Estetrol

Controlled Product

CAS: 15183-37-6

Applications A metabolite of Estradiol. It is an estrogenic steroid synthesized exclusively by the fetal liver during human pregnancy and reaching the maternal circulation through the placenta.
References Gurpide, E., et al.: J. Clin. Endocrinol., 26, 1355 (1966), Hagen, A., et al.: J. Clin. Endocrinol., 30, 763 (1970), Schollberg, K., et al.: Exp. Clin. Endocrinol., 85, 204 (1985), Coelingh Bennink, H., et al.: Contraception, 77, 186 (2008),

Formula: C₁₈H₂₄O₄

Color and Shape: Off White Solid

Molecular weight: 304.38

Ref: TR-E668450

Estetrol

CAS: 15183-37-6

Estetrol (E4) is a naturally occurring estrogen, which is synthesized by the human fetal liver. It acts as a selective estrogen receptor modulator with a unique mode of action differentially impacting various tissues. Estetrol selectively binds to estrogen receptors, thereby facilitating a range of estrogenic activities. Interestingly, it exhibits modest estrogenic effects on both the endometrium and breast tissue, reducing potential risks typically associated with hormone therapies.

Formula: C₁₈H₂₄O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 304.38 g/mol

Ref: 3D-FE22814