CAS 151896-13-8

Dermaseptin II (Phyllomedusasauvagei) (9CI)

Description:

Dermaseptin II is a peptide derived from the skin secretions of the Phyllomedusa sauvagei frog, known for its antimicrobial properties. This substance is characterized by its ability to disrupt microbial membranes, making it effective against a range of bacteria, fungi, and some viruses. Dermaseptin II consists of a sequence of amino acids that contribute to its amphipathic nature, allowing it to interact with lipid bilayers. The peptide exhibits a relatively small molecular weight and is typically cationic, which enhances its interaction with negatively charged microbial membranes. Its structure includes a series of hydrophobic and hydrophilic regions, facilitating its insertion into lipid membranes. Dermaseptin II has garnered interest in biomedical research for potential applications in developing new antimicrobial agents and wound healing therapies. Additionally, its low toxicity to mammalian cells makes it a promising candidate for therapeutic use. Overall, Dermaseptin II exemplifies the potential of natural peptides in combating antibiotic resistance and addressing infectious diseases.

Formula: C₁₅₅H₂₅₅N₄₃O₄₃S₂

Synonyms:

• 12: PN:WO0055337 SEQID: 11 claimed sequence
• 22: PN:WO2007047189 SEQID: 22 unclaimed sequence
• 22: PN: WO2004110143 SEQID: 22 unclaimed sequence
• L-Glutamine,L-alanyl-L-leucyl-L-tryptophyl-L-phenylalanyl-L-threonyl-L-methionyl-L-leucyl-L-lysyl-L-lysyl-L-leucylglycyl-L-threonyl-L-methionyl-L-alanyl-L-leucyl-L-histidyl-L-alanylglycyl-L-lysyl-L-alanyl-L-alanyl-L-leucylglycyl-L-alanyl-L-alanyl-L-alanyl-L-asparaginyl-L-threonyl-L-isoleucyl-L-seryl-L-glutaminylglycyl-L-threonyl-
• 22: PN: US20060147442 SEQID: 22 unclaimedsequence
• DermaseptinI (Phyllomedusa sauvagei), 4-L-phenylalanine-27-L-asparagine-
• 24: PN: US20070104722 SEQID: 22 unclaimed sequence
• Protein (Phyllomedusa sauvagei)
• 23: PN: WO0209738 SEQID: 22unclaimed sequence

Dermaseptin-S2

CAS: 151896-13-8

Dermaseptin-S2, an antimicrobial peptide sourced from frog skin, exhibits activity against filamentous fungi [1].

Formula: C₁₅₅H₂₅₅N₄₃O₄₃S₂

Color and Shape: Solid

Molecular weight: 3473.08

Ref: TM-T80314