8-Bromo-cyclic adenosine diphosphate ribose (8-Br-cADPR) is a synthetic analog of cyclic ADP-ribose, a crucial signaling molecule involved in calcium mobilization and various cellular processes. This compound features a bromine atom substituted at the 8-position of the adenine ring, which enhances its stability and alters its biological activity compared to its natural counterpart. 8-Br-cADPR is known for its role in modulating intracellular calcium levels and influencing various physiological responses, including cell proliferation and apoptosis. The presence of the cyclic diphosphate and ribose moieties contributes to its ability to interact with specific receptors and enzymes, making it a valuable tool in biochemical research. Its CAS number, 151898-26-9, identifies it uniquely in chemical databases, facilitating its study and application in pharmacological and biochemical contexts. Overall, 8-bromo-cyclic adenosine diphosphate ribose serves as an important compound for understanding calcium signaling pathways and exploring potential therapeutic targets.

8-bromo-cyclic adenosine diphosphate*ribose

151898-26-9: 8-Bromo-cyclic adenosine diphosphate ribose (8-Br-cADPR) is a synthetic analog of cyclic ADP-ribose, a crucial signaling molecule involved in calcium mobilization and various cellular processes. This compound features a bromine atom substituted at the 8-position of the adenine ring, which enhances its stability and alters its biological activity compared to its natural counterpart. 8-Br-cADPR is known for its role in modulating intracellular calcium levels and influencing various physiological responses, including cell proliferation and apoptosis. The presence of the cyclic diphosphate and ribose moieties contributes to its ability to interact with specific receptors and enzymes, making it a valuable tool in biochemical research. Its CAS number, 151898-26-9, identifies it uniquely in chemical databases, facilitating its study and application in pharmacological and biochemical contexts. Overall, 8-bromo-cyclic adenosine diphosphate ribose serves as an important compound for understanding calcium signaling pathways and exploring potential therapeutic targets.

8-Bromocyclic adenosine diphosphate ribose sodium salt

<p>8-Bromocyclic adenosine diphosphate ribose sodium salt (8BCAR) is a cytosolic cyclase inhibitor that inhibits the synthesis of cyclic adenosine monophosphate (cAMP). 8BCAR blocks the activation of protein kinase A, which is an enzyme involved in the phosphorylation of cAMP. 8BCAR has been shown to inhibit cardiac hypertrophy induced by growth factor-β1 and to increase mitochondrial membrane potential, as well as to suppress cardiomyocyte apoptosis. In addition, this drug can be used for the treatment of cancers such as leukemia and lymphoma.</p>

CAS 151898-26-9

8-bromo-cyclic adenosine diphosphate*ribose

8-Bromocyclic adenosine diphosphate ribose sodium salt

Ref: 7W-GN9079

8-Bromocyclic adenosine diphosphate ribose sodium

Ref: 3D-NB05042