CAS 152-47-6

Sulfalene

Description:

Sulfalene, with the CAS number 152-47-6, is a chemical compound primarily recognized for its use as a pharmaceutical agent. It is classified as a sulfonamide, which is a group of compounds that contain a sulfonamide functional group (-SO2NH2). Sulfalene exhibits antibacterial properties and has been utilized in the treatment of various infections, particularly those caused by susceptible bacteria. The compound is typically administered in the form of its sodium salt, enhancing its solubility and bioavailability. In terms of physical characteristics, sulfalene is generally a white to off-white crystalline powder. It is soluble in water and exhibits stability under normal storage conditions. The mechanism of action involves the inhibition of bacterial folic acid synthesis, which is crucial for bacterial growth and reproduction. However, like many sulfonamides, sulfalene may cause allergic reactions or adverse effects in some individuals, necessitating careful monitoring during its use. Overall, sulfalene is an important compound in the field of medicinal chemistry, particularly in the development of antibacterial therapies.

Formula: C₁₁H₁₂N₄O₃S

InChI: InChI=1S/C11H12N4O3S/c1-18-11-10(13-6-7-14-11)15-19(16,17)9-4-2-8(12)3-5-9/h2-7H,12H2,1H3,(H,13,15)

InChI key: InChIKey=KXRZBTAEDBELFD-UHFFFAOYSA-N

SMILES: S(NC=1C(OC)=NC=CN1)(=O)(=O)C2=CC=C(N)C=C2

Synonyms:

• 2-(p-Aminobenzenesulfanamide)-3-methoxypyrazine
• 2-(p-Aminobenzenesulfonamido)-3-methoxypyrazine
• 2-Methoxy-3-sulfanilamidopyrazine
• 2-Sulfanilamide 3-methoxy-pyrazine
• 2-Sulfanilamido-3-methoxypyrazine
• 3-Methoxy-2-sulfanilamidopyrazine
• 3-Methoxy-2-sulfapyrazine
• 3-Methoxypyrazine sulfanilamide
• 4-Amino-N-(3-methoxy-2-pyrazinyl)benzenesulfonamide
• 4-Amino-N-(3-methoxypyrazinyl)benzenesulfonamide
• 4-amino-N-(3-methoxypyrazin-2-yl)benzenesulfonamide
• As 18908
• Benzenesulfonamide, 4-amino-N-(3-methoxy-2-pyrazinyl)-
• Benzenesulfonamide, 4-amino-N-(3-methoxypyrazinyl)-
• Brn 0622512
• Dalysep
• F.I. 5978
• Farmitalia 204/122
• Fi 5978
• Kelfizin
• Kelfizina
• Kelfizine
• Kelfizine W
• Longum
• N(sup 1)-(3-Methoxy-2-pyrazinyl)sulfanilamide
• N(sup 1)-(3-Methoxypyrazinyl)sulfanilamide
• N(sup1)-(3-Methoxy-2-pyrazinyl)sulfanilamide
• N(sup1)-(3-Methoxypyrazinyl)sulfanilamide
• N1-(3-Methoxy-2-pyrazinyl)sulfanilamide
• N1-(3-Methoxypyrazinyl)sulfanilamide
• N¹-(3-Methoxy-2-pyrazinyl)sulfanilamide
• Nsc 110433
• Policydal
• Polycidal
• Pyrazine, 2-sulfanilamido-3-methoxy-
• SMP₂
• Smp2
• Solfametopirazina
• Solfametopirazina [DCIT]
• Sulfalen
• Sulfaleno
• Sulfaleno [INN-Spanish]
• Sulfalenum
• Sulfalenum [INN-Latin]
• Sulfamethopyrazine
• Sulfamethoxypyrazine
• Sulfametopyrazine
• Sulfanilamide, N'-(3-methoxypyrazinyl)-
• Sulfanilamide, N(sup 1)-(3-methoxy-2-pyrazinyl)-
• Sulfanilamide, N(sup 1)-(3-methoxypyrazinyl)-
• Sulfanilamide, N1-(3-methoxypyrazinyl)-
• Sulfanilamide, N¹-(3-methoxypyrazinyl)-
• Sulfapyrazinemethoxine
• Sulfapyrazinemethoxyine
• Sulfapyrazinemethoxyne
• Unii-T6Bl4Zc15G
• Vetkelfizina
• Wr 4629

Sulfalene

CAS: 152-47-6

Formula: C₁₁H₁₂N₄O₃S

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 280.30

Ref: 3B-S0917

Sulfalene

CAS: 152-47-6

Color and Shape: Neat

Ref: 61-FOR0968.00

4-Amino-N-(3-methoxypyrazin-2-yl)benzenesulfonamide

CAS: 152-47-6

Formula: C₁₁H₁₂N₄O₃S

Purity: 95%

Color and Shape: Solid

Molecular weight: 280.3030

Ref: IN-DA003KRK

Sulfalene

CAS: 152-47-6

Sulfalene (SMP2), a long-acting sulfonamide antibiotic, is used for the therapy of chronic bronchitis, urinary tract infections, and malaria.

Formula: C₁₁H₁₂N₄O₃S

Purity: 99.24% - 99.52%

Color and Shape: White Or Slightly Yellow Crystal Powder

Molecular weight: 280.3

Ref: TM-T0026

4-Amino-N-(3-Methoxypyrazin-2-Yl)Benzenesulfonamide

CAS: 152-47-6

4-Amino-N-(3-Methoxypyrazin-2-Yl)Benzenesulfonamide

Purity: 99%

Molecular weight: 280.3g/mol

Ref: 54-OR1028580

Sulfalene

CAS: 152-47-6

Sulfalene

Purity: ≥98%

Molecular weight: 280.3g/mol

Ref: 54-BUP17128

Sulfalene (sulfamethoxypyrazine)

CAS: 152-47-6

Formula: C₁₁H₁₂N₄O₃S

Color and Shape: White To Off-White Solid

Molecular weight: 280.31

Ref: 4Z-S-281

Sulfalene

CAS: 152-47-6

Formula: C₁₁H₁₂N₄O₃S

Color and Shape: Neat

Molecular weight: 280.30

Ref: 86-MM0968.00

Sulfalene

CAS: 152-47-6

Formula: C₁₁H₁₂N₄O₃S

Color and Shape: Neat

Molecular weight: 280.30

Ref: 04-C16992000

Sulfalene 100 µg/mL in Acetonitrile

CAS: 152-47-6

Formula: C₁₁H₁₂N₄O₃S

Color and Shape: Single Solution

Molecular weight: 280.30

Ref: 04-A16992000AL-100

Sulfalene-d4 (Sulfamethoxypyrazine-d4)

CAS: 152-47-6

Formula: C₁₁H₈D₄N₄O₃S

Molecular weight: 284.33

Ref: 4Z-S-287

Sulfamethoxypyrazine

Controlled Product

CAS: 152-47-6

Applications A possible antimalarial drug.
References Davidson D.E.Jr. et al; Am. J. Trop. Med. Hyg. 25, 26 (1976)

Formula: C₁₁H₁₂N₄O₃S

Color and Shape: Neat

Molecular weight: 280.30

Ref: TR-S699230

4-Amino-N-(3-methoxypyrazin-2-yl)benzenesulfonamide

CAS: 152-47-6

Formula: C₁₁H₁₂N₄O₃S

Purity: 95%

Color and Shape: White – Almost white powder

Molecular weight: 280.3

Ref: 10-F240593

Sulfalene (SMPZ)

CAS: 152-47-6

Sulfalene (SMPZ) is a sulfa drug that inhibits the ATP-binding cassette transporter, which is important for the absorption of glucose and amino acids. Sulfalene has been shown to cause acute toxicities in the liver, kidney, and gastrointestinal tract. It also inhibits microbial growth by binding to bacterial ribosomes and preventing protein synthesis. Sulfalene has been shown to have activity against certain bacteria, such as Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Enterobacter cloacae. Sulfalene's effects on human intestinal flora are unclear due to its toxicity. However, it has been shown to increase bifidobacteria levels in rats fed with a high-fat diet.

Formula: C₁₁H₁₂N₄O₃S

Purity: Min. 95%

Molecular weight: 280.3 g/mol

Ref: 3D-AAA15247