CAS 152-53-4: Chlorcycloguanil

Description: Chlorcycloguanil, with the CAS number 152-53-4, is an antimalarial compound that belongs to the class of drugs known as antiprotozoals. It is a derivative of cycloguanil, which is itself a metabolite of the widely used antimalarial drug proguanil. Chlorcycloguanil exhibits a mechanism of action that involves the inhibition of dihydrofolate reductase, an enzyme critical for the synthesis of folate in the malaria-causing parasite Plasmodium species. This inhibition disrupts the parasite's ability to replicate and survive. The compound is characterized by its relatively low solubility in water, which can affect its bioavailability and efficacy. Chlorcycloguanil has been studied for its potential use in combination therapies to enhance the effectiveness of other antimalarial agents and to combat drug resistance. Its safety profile and pharmacokinetics are important considerations in its application for malaria treatment. Overall, chlorcycloguanil represents a significant compound in the ongoing efforts to develop effective antimalarial therapies.

Formula: C₁₁H₁₄ClN₅·ClH

InChI: InChI=1S/C11H14ClN5.ClH/c1-11(2)16-9(13)15-10(14)17(11)8-5-3-7(12)4-6-8;/h3-6H,1-2H3,(H4,13,14,15,16);1H

InChI key: InChIKey=MOUAPRKJJUXEIE-UHFFFAOYSA-N

SMILES: Cl.ClC1=CC=C(C=C1)N2C(=NC(=NC2(C)C)N)N

Synonyms:

• 1,3,5-Triazine-2,4-diamine, 1-(4-chlorophenyl)-1,6-dihydro-6,6-dimethyl-, hydrochloride (1:1)
• 1,3,5-Triazine-2,4-diamine, 1-(4-chlorophenyl)-1,6-dihydro-6,6-dimethyl-, monohydrochloride
• 1-(4-Chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamine Hydrochloride
• 1-(4-Chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamine monohydrochloride
• 1-(4-Chlorophenyl)-6,6-Dimethyl-1,6-Dihydro-1,3,5-Triazine-2,4-Diamine Hydrochloride (1:1)
• 1-(4-Chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine hydrochloride
• 1-(4-Chlorophenyl-d4)-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamine Hydrochloride
• Bn 2410
• Chlorcycloguanil
• Chloroguanide Triazine Hydrochloride
• Chloroguanide-d4 Triazine Hydrochloride
• Cycloguanil-d4 Hydrochloride
• Nsc 3074
• s-Triazine, 4,6-diamino-1-(p-chlorophenyl)-1,2-dihydro-2,2-dimethyl-, hydrochloride
• s-Triazine, 4,6-diamino-1-(p-chlorophenyl)-1,2-dihydro-2,2-dimethyl-, monohydrochloride

Cycloguanil hydrochloride

CAS: 152-53-4

• Formula: C₁₁H₁₅Cl₂N₅
• Purity: 97%
• Color and Shape: Solid
• Molecular weight: 288.1763

Cycloguanil hydrochloride

CAS: 152-53-4

• Purity: 99.46%
• Molecular weight: 288.18g/mol

1-(4-Chlorophenyl)-6,6-Dimethyl-1,6-Dihydro-1,3,5-Triazine-2,4-Diamine Hydrochloride

CAS: 152-53-4

• Purity: 98%+
• Molecular weight: 288.18g/mol

Cycloguanil Hydrochloride

CAS: 152-53-4

• Formula: C₁₁H₁₄ClN₅·ClH
• Color and Shape: Neat
• Molecular weight: 288.18

Cycloguanil Hydrochloride

CAS: 152-53-4

• Formula: C₁₁H₁₄ClN₅·HCl
• Purity: >95.0%(T)(HPLC)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 288.18

Cycloguanil hydrochloride

CAS: 152-53-4

Cycloguanil hydrochloride, proguanil's metabolite, inhibits Plasmodium/human dihydrofolate reductase (Ki: 0.3/1.5 nM).

• Formula: C₁₁H₁₄ClN₅·ClH
• Purity: 98.72%
• Color and Shape: Solid
• Molecular weight: 288.18

Cycloguanil Hydrochloride

CAS: 152-53-4

• Formula: C₁₁H₁₄ClN₅·ClH
• Color and Shape: Neat
• Molecular weight: 288.18

Cycloguanil hydrochloride

CAS: 152-53-4

• Purity: 95.0%
• Color and Shape: Liquid, No data available.
• Molecular weight: 288.17999267578125

Cycloguanil hydrochloride

CAS: 152-53-4

Please enquire for more information about Cycloguanil hydrochloride including the price, delivery time and more …

• Formula: C₁₁H₁₄ClN₅•HCl
• Purity: Min. 98 Area-%
• Color and Shape: Powder
• Molecular weight: 288.18 g/mol