CAS 152-53-4

Chlorcycloguanil

Description:

Chlorcycloguanil, with the CAS number 152-53-4, is an antimalarial compound that belongs to the class of drugs known as antiprotozoals. It is a derivative of cycloguanil, which is itself a metabolite of the widely used antimalarial drug proguanil. Chlorcycloguanil exhibits a mechanism of action that involves the inhibition of dihydrofolate reductase, an enzyme critical for the synthesis of folate in the malaria-causing parasite Plasmodium species. This inhibition disrupts the parasite's ability to replicate and survive. The compound is characterized by its relatively low solubility in water, which can affect its bioavailability and efficacy. Chlorcycloguanil has been studied for its potential use in combination therapies to enhance the effectiveness of other antimalarial agents and to combat drug resistance. Its safety profile and pharmacokinetics are important considerations in its application for malaria treatment. Overall, chlorcycloguanil represents a significant compound in the ongoing efforts to develop effective antimalarial therapies.

Formula: C₁₁H₁₄ClN₅·ClH

InChI: InChI=1S/C11H14ClN5.ClH/c1-11(2)16-9(13)15-10(14)17(11)8-5-3-7(12)4-6-8;/h3-6H,1-2H3,(H4,13,14,15,16);1H

InChI key: InChIKey=MOUAPRKJJUXEIE-UHFFFAOYSA-N

SMILES: CC1(C)N(C(N)=NC(N)=N1)C2=CC=C(Cl)C=C2.Cl

Synonyms:

• 1,3,5-Triazine-2,4-diamine, 1-(4-chlorophenyl)-1,6-dihydro-6,6-dimethyl-, hydrochloride (1:1)
• 1,3,5-Triazine-2,4-diamine, 1-(4-chlorophenyl)-1,6-dihydro-6,6-dimethyl-, monohydrochloride
• 1-(4-Chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamine Hydrochloride
• 1-(4-Chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamine monohydrochloride
• 1-(4-Chlorophenyl)-6,6-Dimethyl-1,6-Dihydro-1,3,5-Triazine-2,4-Diamine Hydrochloride (1:1)
• 1-(4-Chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine hydrochloride
• 1-(4-Chlorophenyl-d4)-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamine Hydrochloride
• Bn 2410
• Chlorcycloguanil
• Chloroguanide Triazine Hydrochloride
• Chloroguanide-d4 Triazine Hydrochloride
• Cycloguanil-d4 Hydrochloride
• Nsc 3074
• s-Triazine, 4,6-diamino-1-(p-chlorophenyl)-1,2-dihydro-2,2-dimethyl-, hydrochloride

Cycloguanil Hydrochloride

CAS: 152-53-4

Color and Shape: Neat

Ref: 61-FOR1580.00

Cycloguanil hydrochloride

CAS: 152-53-4

Formula: C₁₁H₁₅Cl₂N₅

Purity: 95%

Color and Shape: Solid

Molecular weight: 288.1763

Ref: IN-DA003P44

Cycloguanil hydrochloride

CAS: 152-53-4

Cycloguanil hydrochloride

Purity: ≥98%

Molecular weight: 288.18g/mol

Ref: 54-BUP10267

1-(4-Chlorophenyl)-6,6-Dimethyl-1,6-Dihydro-1,3,5-Triazine-2,4-Diamine Hydrochloride

CAS: 152-53-4

1-(4-Chlorophenyl)-6,6-Dimethyl-1,6-Dihydro-1,3,5-Triazine-2,4-Diamine Hydrochloride

Purity: 98%

Molecular weight: 288.18g/mol

Ref: 54-OR1008942

Cycloguanil Hydrochloride

Controlled Product

CAS: 152-53-4

Formula: C₁₁H₁₄ClN₅·ClH

Color and Shape: Neat

Molecular weight: 288.18

Ref: 86-MM1580.00

Cycloguanil Hydrochloride

CAS: 152-53-4

Formula: C₁₁H₁₄ClN₅·HCl

Purity: >95.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 288.18

Ref: 3B-C3900

Cycloguanil hydrochloride

CAS: 152-53-4

Cycloguanil hydrochloride, proguanil's metabolite, inhibits Plasmodium/human dihydrofolate reductase (Ki: 0.3/1.5 nM).

Formula: C₁₁H₁₄ClN₅·ClH

Purity: 98.72%

Color and Shape: Solid

Molecular weight: 288.18

Ref: TM-T5420

Cycloguanil Hydrochloride

CAS: 152-53-4

Formula: C₁₁H₁₄ClN₅·ClH

Color and Shape: Neat

Molecular weight: 288.18

Ref: TR-C987880

Cycloguanil hydrochloride

CAS: 152-53-4

Cycloguanil hydrochloride is an anti-malarial drug that inhibits the activity of dihydrofolate reductase, which is a target enzyme for many drugs. The drug is structurally similar to proguanil, but the latter has more potent activity against the parasite and better oral bioavailability. Cycloguanil hydrochloride binds to the enzyme's active site and blocks its action, thereby inhibiting essential enzymes in the synthesis of DNA. This leads to a decrease in production of malarial parasites and inhibition of their growth. Cycloguanil hydrochloride can also be used for chemoprophylaxis in falciparum malaria when combined with other drugs such as sulfadoxine or pyrimethamine.

Formula: C₁₁H₁₄ClN₅•HCl

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 288.18 g/mol

Ref: 3D-FC20690

Cycloguanil hydrochloride

CAS: 152-53-4

Formula: C₁₁H₁₅Cl₂N₅

Purity: 97%

Color and Shape: Liquid, No data available.

Molecular weight: 288.18

Ref: 10-F235265