CAS 152-62-5

Dydrogesterone

Description:

Dydrogesterone, with the CAS number 152-62-5, is a synthetic progestogen, which is a type of hormone that mimics the effects of progesterone, a natural hormone involved in the menstrual cycle and pregnancy. It is characterized by its ability to regulate various reproductive processes, making it useful in treating conditions such as amenorrhea, endometriosis, and certain types of infertility. Dydrogesterone is typically administered orally and is known for its favorable safety profile, as it does not exhibit significant androgenic or estrogenic activity. The substance is generally well-absorbed in the gastrointestinal tract and has a relatively short half-life, necessitating regular dosing. Its chemical structure features a steroid backbone, which is common among progestogens, and it is often formulated in various pharmaceutical preparations. Due to its specific action on the progesterone receptors, dydrogesterone plays a crucial role in hormone replacement therapy and in managing various gynecological disorders.

Formula: C₂₁H₂₈O₂

InChI: InChI=1/C21H28O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4-5,12,16-19H,6-11H2,1-3H3/t16-,17+,18-,19+,20?,21+/m0/s1

InChI key: InChIKey=JGMOKGBVKVMRFX-HQZYFCCVSA-N

SMILES: C[C@]12[C@]3([C@]([C@]4([C@](C)(CC3)[C@@H](C(C)=O)CC4)[H])(C=CC1=CC(=O)CC2)[H])[H]

Synonyms:

• (9Beta,10Xi)-Pregna-4,6-Diene-3,20-Dione
• (9b,10a)-Pregna-4,6-diene-3,20-dione
• (9beta,10alpha)-Pregna-4,6-diene-3,20-dione
• .DELTA.6-Retroprogesterone
• 10a-Isopregnenone
• 6-Dehydro-9.beta.,10.alpha.-progesterone
• 6-Dehydro-9b,10a-progesterone
• 6-Dehydroretroprogesterone
• 6α-Dehydro-retro-Δ4-pregnene-3,20-dione
• 6α-Dehydro-retro-Δ⁴-pregnene-3,20-dione
• 9beta,10alpha-Pregna-4,6-diene-3,20-dione (8CI)
• D6-Retroprogesterone
• Didrogesterona
• Diphaston
• Dufaston
• Duphaston
• Duvaron
• Dydrogesteron
• Gestatron
• Gynorest
• Hydrogesterone
• Isopregnenone
• Nsc 92336
• Pregna-4,6-diene-3,20-dione, (9β,10α)-
• Prodel
• Retro-6-dehydroprogesterone
• Retrone
• Retroprogesterone, 6-dehydro-
• Terolut
• Δ⁶-Retroprogesterone
• dyhdrogesterone
• 6-dehydro-9beta,10alpha-progesterone
• 10alpha-isopregnenone
• delta(sup6)-retroprogesterone
• 20-dione,(9beta,10alpha)-pregna-6-diene-3
• 17-acetyl-10,13-dimethyl-1,2,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one
• 6-dehydro-retro-progesterone
• 20-dione,(9-beta,10-alpha)-pregna-6-diene-3
• 6-dehydro-retroprogesteron
• 10α-pregna-4,6-diene-3,20-dione

Dydrogesterone

CAS: 152-62-5

Color and Shape: Neat

Ref: 61-FOR0328.00

DYDROGESTERONE CRS

CAS: 152-62-5

DYDROGESTERONE CRS

Ref: 41-Y0001004

Dydrogesterone

CAS: 152-62-5

Estrogens and progestins

Formula: C₂₁H₂₈O₂

Color and Shape: White Off-White Solid

Molecular weight: 312.20893

Ref: 45-1231003

Dydrogesterone

CAS: 152-62-5

Formula: C₂₁H₂₈O₂

Color and Shape: White To Off-White Solid

Molecular weight: 312.45

Ref: 4Z-D-123001

Dydrogesterone-d6

CAS: 152-62-5

Formula: C₂₁H₂₂D₆O₂

Molecular weight: 318.49

Ref: 4Z-D-123005

Dydrogesterone

CAS: 152-62-5

Dydrogesterone

Purity: ≥98%

Molecular weight: 312.45g/mol

Ref: 54-BUP12472

Dydrogesterone

CAS: 152-62-5

Formula: C₂₁H₂₈O₂

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 312.45

Ref: 3B-D6262

Dydrogesterone

CAS: 152-62-5

Dydrogesterone is a potent progestogen which can be used in progesterone deficiency studies.

Formula: C₂₁H₂₈O₂

Purity: 99.78% - 99.87%

Color and Shape: Crystals From Acetone + Hexane Solid

Molecular weight: 312.45

Ref: TM-T3036

Dydrogesterone

Controlled Product

CAS: 152-62-5

Applications A synthetic progestin largely used in hormone therapy, on the central nervous system by studying two markers of the neuroendocrine function: the neurosteroid allopregnanolone and the opioid .beta.-endorphin. Progestogen.
References Bernardi, F., et al.: Eur. J. Endocrinol., 138, 316 (1998), Rupprecht, R., et al.: Steroids, 64, 83 (1999), Uzunova, V., et al.: Brain Res., 976, 1 (2003), Pluchino, N., et al.: J. Steroid Biochem. Mol. Biol., 102, 205 (2006),

Formula: C₂₁H₂₈O₂

Color and Shape: Neat

Molecular weight: 312.45

Ref: TR-D826000

Dydrogesterone-d6 (Major)

Controlled Product

CAS: 152-62-5

Applications Labelled Dydrogesterone. A synthetic progestin largely used in hormone therapy, on the central nervous system by studying two markers of the neuroendocrine function: the neurosteroid allopregnanolone and the opioid .beta.-endorphin. Progestogen.
References Bernardi, F., et al.: Eur. J. Endocrinol., 138, 316 (1998), Rupprecht, R., et al.: Steroids, 64, 83 (1999), Uzunova, V., et al.: Brain Res., 976, 1 (2003), Pluchino, N., et al.: J. Steroid Biochem. Mol. Biol., 102, 205 (2006),

Formula: C₂₁H₂₂D₆O₂

Color and Shape: Neat

Molecular weight: 318.48

Ref: TR-D826002

Dydrogesterone

Controlled Product

CAS: 152-62-5

Dydrogesterone is a progestin medication that is used to treat symptoms of endometriosis in women. It can be used alone or in combination with estradiol benzoate. Dydrogesterone is not active against bacteria. High-sensitivity C-reactive protein (hsCRP) levels are an indicator of inflammation and have been shown to be elevated in untreated women with endometriosis. Histological analysis of tissue from these patients has revealed increased levels of dydrogesterone. Dydrogesterone binds to the progesterone receptor, which regulates the expression of genes that play a role in cell proliferation and differentiation. This regulation is mediated by nuclear DNA, which is transcribed into messenger RNA and translated into protein by ribosomes. Coumarin derivatives inhibit the production of mRNA by binding to the enzyme RNA polymerase II, which catalyzes the transcription process. Studies have shown that coumarin derivatives can reduce

Formula: C₂₁H₂₈O₂

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 312.45 g/mol

Ref: 3D-FD22631

Dydrogesterone

CAS: 152-62-5

Dydrogesterone

Color and Shape: White

Ref: 47-138