CAS 152-97-6

Flucortolone

Description:

Flucortolone is a synthetic corticosteroid with anti-inflammatory and immunosuppressive properties, primarily used in the treatment of various inflammatory and autoimmune conditions. It is characterized by its ability to modulate the immune response and reduce inflammation by inhibiting the release of inflammatory mediators. Flucortolone is typically administered in the form of its acetate derivative, which enhances its bioavailability and therapeutic efficacy. The substance exhibits a relatively high potency compared to other corticosteroids, making it effective at lower doses. Its mechanism of action involves binding to glucocorticoid receptors, leading to alterations in gene expression that ultimately result in decreased inflammation and immune response. Flucortolone is often utilized in dermatology, rheumatology, and other medical fields for conditions such as eczema, psoriasis, and rheumatoid arthritis. However, like other corticosteroids, it may have side effects, including potential adrenal suppression, weight gain, and increased susceptibility to infections, necessitating careful monitoring during treatment.

Formula: C₂₂H₂₉FO₄

InChI: InChI=1S/C22H29FO4/c1-11-6-14-13-8-16(23)15-7-12(25)4-5-21(15,2)20(13)17(26)9-22(14,3)19(11)18(27)10-24/h4-5,7,11,13-14,16-17,19-20,24,26H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19-,20-,21+,22+/m1/s1

InChI key: InChIKey=GAKMQHDJQHZUTJ-ULHLPKEOSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C([C@@H](F)C3)=CC(=O)C=C4)([C@@H](O)C1)[H])[H])(C[C@@H](C)[C@@H]2C(CO)=O)[H]

Synonyms:

• (6Alpha,11Beta,16Alpha)-6-Fluoro-11,21-Dihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione
• (6α,11β,16α)-6-Fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
• 16α-Methyl-6α-fluoro-Δ^1,4-pregnadien-11β,21-diol-3,20-dione
• 6-Alpha-Fluoro-11-Beta,21-Dihydroxy-16-Alpha-Methylpregna-1,4-Diene-3,20-Dione
• 6α-Fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione
• 6α-Fluoro-16α-methyl-1,4-pregnadiene-11β,21-diol-3,20-dione
• 6α-Fluoro-16α-methyl-Δ^1,4-pregnadiene-11β,21-diol-3,20-dione
• 6α-Fluoro-16α-methyl-Δ¹-corticosterone
• Flucortolone
• Fluocortolon
• Methylfluorodehydrocorticosterone
• Pregna-1,4-diene-3,20-dione, 6-fluoro-11,21-dihydroxy-16-methyl-, (6α,11β,16α)-
• Pregna-1,4-diene-3,20-dione, 6α-fluoro-11β,21-dihydroxy-16α-methyl-
• Sh 742

Fluocortolone (Fluocortolone Pivalate EP Impurity A)

CAS: 152-97-6

Formula: C₂₂H₂₉FO₄

Color and Shape: White To Off-White Solid

Molecular weight: 376.47

Ref: 4Z-F-071002

Fluocortolone

Controlled Product

CAS: 152-97-6

Applications Fluocortolone is a glucocorticoid used in the treatment of several conditions, including hemorrhoids. Fluocortolone is similar to Fluocortin, but with one less keto group.
References Breuer, et al.: Arzneim.-Forsch., 15, 50 (1965), Domenico, et al.: Arzneim.-Forsch., 15, 46 (1965), Gerhards, et al.: Acta Endocrinol., 68, 98 (1971),

Formula: C₂₂H₂₉FO₄

Color and Shape: Off-White To Yellow

Molecular weight: 376.46

Ref: TR-F500500

Fluocortolone-d3

Controlled Product

CAS: 152-97-6

Applications Labelled Fluocortolone (F500500). Glucocorticoid.
References Breuer, et al.: Arzneim.-Forsch., 15, 50 (1965), Domenico, et al.: Arzneim.-Forsch., 15, 46 (1965), Gerhards, et al.: Acta Endocrinol., 68, 98 (1971),

Formula: C₂₂D₃H₂₆FO₄

Color and Shape: Off-White To Yellow

Molecular weight: 379.48

Ref: TR-F500502

Fluocortolone

Controlled Product

CAS: 152-97-6

Fluocortolone is a corticosteroid that can be used to treat a variety of inflammatory diseases. It has been shown to have an effect on the production of eosinophil cationic protein and other chemical mediators in the colon, which may be involved in inflammatory bowel disease. Fluocortolone has also been shown to have anti-inflammatory properties in autoimmune diseases and bowel disease, as well as treating choroidal neovascularization, skin cancer, and t-cell lymphomas. Long-term efficacy and high values for disease activity have been observed for this drug, with untreated groups showing improvement.

Formula: C₂₂H₂₉FO₄

Purity: Min. 95 Area-%

Color and Shape: Powder

Molecular weight: 376.46 g/mol

Ref: 3D-FF23336

Fluocortolone

CAS: 152-97-6

Formula: C₂₂H₂₉FO₄

Purity: 96%

Color and Shape: Solid

Molecular weight: 376.4617

Ref: IN-DA00ALYV