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CAS 152186-43-1

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Cefotaxime

Description:
Cefotaxime is a broad-spectrum cephalosporin antibiotic, primarily used to treat a variety of bacterial infections. It is effective against both Gram-positive and Gram-negative bacteria, making it a versatile choice in clinical settings. The chemical structure of cefotaxime includes a beta-lactam ring, which is essential for its antibacterial activity, as it inhibits bacterial cell wall synthesis. Cefotaxime is typically administered via injection and is known for its relatively good penetration into tissues and fluids, including the central nervous system. It is often used to treat infections such as pneumonia, urinary tract infections, and sepsis. The substance is generally well-tolerated, but potential side effects can include allergic reactions, gastrointestinal disturbances, and alterations in blood cell counts. Its pharmacokinetics involve rapid absorption and distribution, with a half-life that allows for convenient dosing schedules. As with all antibiotics, appropriate use is crucial to prevent the development of resistance.
Formula:C16H17N5O7S2
InChI:InChI=1/C16H17N5O7S2/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26)/b20-9-/t10-,14-/m0/s1
SMILES:CC(=O)OCC1=C(C(=O)O)N2C(=O)[C@@H]([C@@H]2SC1)N=C(/C(=N\OC)/c1csc(=N)[nH]1)O
Synonyms:
  • Cefotaxima acid
  • (6R,7R)-3-[(Acetyl-oxy)methyl]-7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)-acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-, (6R,7R)-
  • Cefabol
  • Cephotaxime
  • (((2-amino- 4-thiazolyl)methoxyimino)acetyl)amino)-8-oxo-, (6r-(6alpha,7beta(z) 3-[(Acetyloxy)methyl]-7-[[(2-amino-4-thiazoly)(methoxyimino)acethyl]amino]-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid(sodium salt)
  • Cefotaxime acid
  • (6R,7R)-3-[(acetyloxy)methyl]-7-{[(2-amino-1,3-thiazol-4-yl)(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • (6R,7R)-3-[(acetyloxy)methyl]-7-{[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • (6R,7R)-3-[(acetyloxy)methyl]-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • See more synonyms
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