CAS 152286-31-2

amyloid B-protein fragment 10-20

Description:

Amyloid beta-protein fragment 10-20, associated with Alzheimer's disease, is a peptide derived from the larger amyloid precursor protein. This fragment consists of 11 amino acids, specifically the sequence that plays a crucial role in the formation of amyloid plaques in the brain, which are characteristic of Alzheimer's pathology. The CAS number 152286-31-2 identifies this specific peptide, which is known for its ability to aggregate and form fibrils, contributing to neurotoxicity. The fragment exhibits hydrophobic properties, facilitating its interaction with lipid membranes and other proteins. Its structure allows for the formation of beta-sheet conformations, which are essential for its aggregation behavior. Research on this peptide focuses on understanding its role in neurodegeneration and exploring potential therapeutic interventions. Additionally, it serves as a model for studying amyloid formation and the mechanisms underlying protein misfolding diseases. Overall, amyloid beta-protein fragment 10-20 is significant in both biochemical research and the development of strategies to combat Alzheimer's disease.

Formula: C₇₁H₉₉N₁₇O₁₆

Synonyms:

• Amyloid .beta.-Protein (10-20)
• H-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-OH

Amyloid β-Protein (10-20)

CAS: 152286-31-2

The amyloid precursor protein (APP) is cleaved within the amyloid β-protein region by a putative APP secretase to release its extracellular portion. Gelatinase A, the matrix metalloproteinase MMP-2, possesses such APP secretase-like activity, effectively hydrolyzing also the synthetic amyloid β-protein fragment (10-20) YEVHHQKLVFF at the normal processing site, the Lys¹⁶-Leu¹⁷ bond (Km approx. 0.13 mM).

Formula: C₇₁H₉₉N₁₇O₁₆

Purity: 99.2%

Color and Shape: White

Molecular weight: 1446.67

Ref: 01-4030332

β-Amyloid (10-20)

CAS: 152286-31-2

Amyloid β-Protein (10-20) is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease.Amyloid β protein fragment containing the α-

Formula: C₇₁H₉₉N₁₇O₁₆

Purity: 98%

Color and Shape: Lyophilized Powder

Molecular weight: 1446.65

Ref: TM-TP1786

Amyloid beta-Protein (10-20)

CAS: 152286-31-2

Amyloid beta-protein (Aβ) is a peptide that is found in the brain. Aβ has been shown to be involved in Alzheimer's disease, Parkinson's disease, and other neurodegenerative diseases. Aβ can be used as a biomarker for these diseases because it accumulates in the brain and blood of patients with these diseases. It is hypothesized that Aβ binds to cell surface proteins, such as choline receptors, which disrupts the function of neurons. This leads to decreased production of acetylcholine and eventual death of neurons. This study sought to identify inhibitors of Aβ aggregation by screening a library of small molecules against Aβ aggregates. The screen identified several potential anticancer compounds that are acidic and reactive. These compounds have been shown to inhibit polymerase chain reaction (PCR) amplification at nanomolar concentrations. In addition, they have been shown to reduce the expression of phosphofructokinase (PFK), an enzyme important in gly

Formula: C₇₁H₉₉N₁₇O₁₆

Purity: Min. 95%

Molecular weight: 1,446.65 g/mol

Ref: 3D-FA108433