CAS 1524-86-3

(11β,16α)-9-Fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione

Description:

The chemical substance known as "(11β,16α)-9-Fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione," with the CAS number 1524-86-3, is a synthetic corticosteroid. It exhibits anti-inflammatory and immunosuppressive properties, making it useful in various medical applications, particularly in treating conditions such as asthma, allergies, and autoimmune disorders. The structure of this compound features a fluorine atom, which enhances its potency and metabolic stability compared to other corticosteroids. The presence of hydroxyl groups contributes to its solubility and biological activity. Additionally, the compound's steroidal backbone is characteristic of glucocorticoids, which interact with glucocorticoid receptors to exert their effects. Its unique structural modifications, including the methylethylidene group, influence its pharmacokinetics and therapeutic efficacy. Overall, this compound is significant in pharmacology for its role in managing inflammatory responses and modulating immune function.

Formula: C₂₄H₃₃FO₆

InChI: InChI=1S/C24H33FO6/c1-20(2)30-19-10-16-15-6-5-13-9-14(27)7-8-21(13,3)23(15,25)17(28)11-22(16,4)24(19,31-20)18(29)12-26/h9,15-17,19,26,28H,5-8,10-12H2,1-4H3/t15-,16-,17-,19+,21-,22-,23-,24+/m0/s1

InChI key: InChIKey=TZFZVQNBXVBQDC-JNQJZLCISA-N

SMILES: C(CO)(=O)[C@]12[C@]3(C)[C@@](C[C@]1(OC(C)(C)O2)[H])([C@]4([C@](F)([C@@H](O)C3)[C@]5(C)C(CC4)=CC(=O)CC5)[H])[H]

Synonyms:

• (11β,16α)-9-Fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione
• (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS)-4b-fluoro-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-tetradecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
• 11β,16α,17α,21-Tetrahydroxy-9α-fluoropregn-4-ene-3,20-dione 16,17-acetonide
• 2H-Naphth[2′,1′:4,5]indeno[1,2-d][1,3]dioxole, pregn-4-ene-3,20-dione deriv.
• 4b-fluoro-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-tetradecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
• 9-Fluoro-11beta,21-dihydroxy-16alpha,17-(isopropylidenedioxy)pregn-4-ene-3,20-dione
• Corticosterone, 9-fluoro-16α,17-dihydroxy-, cyclic 16,17-acetal with Me₂CO
• NSC 21915
• Pregn-4-ene-3,20-dione, 9-fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (11β,16α)-
• Pregn-4-ene-3,20-dione, 9-fluoro-11β,16α,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone
• Corticosterone, 9-fluoro-16α,17-dihydroxy-, cyclic 16,17-acetal with Me2CO

Triamcinolone Acetonide EP Impurity E

CAS: 1524-86-3

Formula: C₂₄H₃₃FO₆

Color and Shape: White To Off-White Solid

Molecular weight: 436.52

Ref: 4Z-T-5322

9-Fluoro-16α,17-(isopropylidenedioxy) Corticosterone

Controlled Product

CAS: 1524-86-3

Impurity Triamcinolone Acetonide EP Impurity E
Applications 9-Fluoro-16α,17-(isopropylidenedioxy) Corticosterone (Triamcinolone Acetonide EP Impurity E) is a synthetic fluorinated corticosteroid tested for inhibition of granuloma in rats and for vasoconstriction activity in human subjects; potential topical antiinflammatory agent.
References Hannah, J. et al.: J. Med. Chem., 18, 168 (1975);

Formula: C₂₄H₃₃FO₆

Color and Shape: Neat

Molecular weight: 436.51

Ref: TR-F592050

Triamcinolone Acetonide EP Impurity E

CAS: 1524-86-3

Formula: C₂₄H₃₃FO₆

Molecular weight: 436.52

Ref: ST-EA-CP-T78005