CAS 152612-69-6

N-Acetyl-D-serine

Description:

N-Acetyl-D-serine is a derivative of the amino acid D-serine, characterized by the addition of an acetyl group to its amino group. This modification enhances its solubility in water and may influence its biological activity. The compound is typically a white to off-white crystalline powder and is soluble in polar solvents. N-Acetyl-D-serine plays a role in various biochemical processes, particularly in the central nervous system, where it is involved in neurotransmission and may act as a co-agonist at NMDA receptors. Its potential therapeutic applications are being explored in the context of neurological disorders, given its involvement in synaptic plasticity and cognitive functions. The compound is generally stable under standard laboratory conditions but should be stored in a cool, dry place to maintain its integrity. As with many amino acid derivatives, it is important to handle N-Acetyl-D-serine with care, following appropriate safety protocols to avoid any adverse reactions.

Formula: C₅H₉NO₄

InChI: InChI=1/C5H9NO4/c1-3(8)6-4(2-7)5(9)10/h4,7H,2H2,1H3,(H,6,8)(H,9,10)/t4-/m1/s1

InChI key: InChIKey=JJIHLJJYMXLCOY-SCSAIBSYSA-N

SMILES: [C@H](NC(C)=O)(C(O)=O)CO

Synonyms:

• (2R)-2-Acetamido-3-hydroxypropanoic acid
• (R)-(+)-2-(N-Acetylamino)-3-hydroxypropanoic acid
• <span class="text-smallcaps">D</span>-Serine, N-acetyl-
• Acetyl-D-serine
• D-serine, N-acetyl-
• N-Acetyl-<span class="text-smallcaps">D</span>-serine
• N-Acetyl-D-serine
• N-Acetyl-D-serine
• 152612-69-6
• N-α-Acetyl-D-serine
• (R)-2-Acetamido-3-hydroxypropanoic acid

N-acetyl-D-serine

CAS: 152612-69-6

Formula: C₅H₉NO₄

Molecular weight: 147.13

Ref: 4Z-C-11309

N-Acetyl-D-serine

Controlled Product

CAS: 152612-69-6

Applications N-Acetyl-D-serine is the modified amino acid D-Serine (S270975). D-Serine is a neurotransmitter that is concentrated in the mammalian brain, and is one of the very few amino acids that occur in the D- and L-configurations in significant amounts. D-Serine is an potent agonist of the N-methyl-D-aspartate (NMDA) receptor in the brain, which is associated with schizophrenia. Use of D-Serine has been considered as an additional therapy for refractory schizophrenic patients.
References Heresco-Levy, U., et al.: Biol. Psych., 57, 577 (2005); Mothet, J., et al.: Proc. Nat. Acad. Sci., 97, 4926 (2000); Snyder, S. & Kim, P.: Neurochem. Res., 25, 553 (2000); Tsai, G., et al.: Biol. Psych., 44, 1081 (1998)

Formula: C₅H₉NO₄

Color and Shape: Neat

Molecular weight: 147.13

Ref: TR-A178340