CAS 15270-30-1

Estradiol 3-glucuronide

Description:

Estradiol 3-glucuronide is a metabolite of estradiol, a potent estrogen hormone, and is formed through the conjugation of estradiol with glucuronic acid. This process enhances the solubility of estradiol, facilitating its excretion from the body. The compound is characterized by its role in the metabolism of estrogens, particularly in the liver, where it undergoes phase II metabolism. Estradiol 3-glucuronide is typically found in biological fluids, including urine and serum, and serves as a biomarker for estrogen exposure and metabolism. It is a polar compound, which contributes to its water solubility, and is often analyzed using techniques such as liquid chromatography coupled with mass spectrometry. The presence of this glucuronide can provide insights into hormonal balance and is relevant in studies related to reproductive health, endocrine function, and certain diseases influenced by estrogen levels. Understanding its characteristics is crucial for research in pharmacology, toxicology, and endocrinology.

Formula: C₂₄H₃₂O₈

InChI: InChI=1S/C24H32O8/c1-24-9-8-14-13-5-3-12(10-11(13)2-4-15(14)16(24)6-7-17(24)25)31-23-20(28)18(26)19(27)21(32-23)22(29)30/h3,5,10,14-21,23,25-28H,2,4,6-9H2,1H3,(H,29,30)/t14-,15-,16+,17+,18+,19+,20-,21+,23-,24+/m1/s1

InChI key: InChIKey=MUOHJTRCBBDUOW-QXYWQCSFSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@](C=4C(CC3)=CC(O[C@@H]5O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]5O)=CC4)(CC1)[H])[H])(CC[C@@H]2O)[H]

Synonyms:

• (17beta)-17-hydroxyestra-1,3,5(10)-trien-3-yl beta-D-glucopyranosiduronic acid
• (17β)-17-Hydroxyestra-1,3,5(10)-trien-3-yl β-<span class="text-smallcaps">D</span>-glucopyranosiduronic acid
• (8xi,9xi,14xi,17beta)-17-hydroxyestra-1,3,5(10)-trien-3-yl beta-D-glucopyranosiduronic acid
• 17alpha-Estradiol-3-glucuronide
• 17β-Estradiol 3-glucosiduronate
• 17β-Estradiol 3-glucuronide
• Estradiol 3-glucosiduronate
• Estradiol-17β-3-(β-<span class="text-smallcaps">D</span>-glucuronide)
• Estrane, β-<span class="text-smallcaps">D</span>-glucopyranosiduronic acid deriv.
• Glucopyranosiduronic acid, 17β-hydroxyestra-1,3,5(10)-trien-3-yl, β-<span class="text-smallcaps">D</span>-
• beta-D-Glucopyranosiduronic acid, (17beta)-17-hydroxyestra-1,3,5(10)-trien-3-yl-
• β-<span class="text-smallcaps">D</span>-Glucopyranosiduronic acid, (17β)-17-hydroxyestra-1,3,5(10)-trien-3-yl
• β-<span class="text-smallcaps">D</span>-Glucosiduronic acid, 17β-hydroxyestra-1,3,5(10)-trien-3-yl
• (17β)-17-Hydroxyestra-1,3,5(10)-trien-3-yl β-D-glucopyranosiduronic acid
• Glucopyranosiduronic acid, 17β-hydroxyestra-1,3,5(10)-trien-3-yl, β-D-
• β-D-Glucopyranosiduronic acid, (17β)-17-hydroxyestra-1,3,5(10)-trien-3-yl
• Estrane, β-D-glucopyranosiduronic acid deriv.
• Estradiol-3-glucuronide

Estradiol-3-Glucuronide

CAS: 15270-30-1

Formula: C₂₄H₃₂O₈

Color and Shape: White To Off-White Solid

Molecular weight: 448.51

Ref: 4Z-E-093

Estradiol 3-O-β-D-glucuronide

CAS: 15270-30-1

Estradiol 3-O-β-D-glucuronide

Formula: C₂₄H₃₂O₈

Purity: By hplc: 97.09% (Typical Value in Batch COA)

Color and Shape: white solid

Molecular weight: 448.51g/mol

Ref: 54-BICL2230

Estradiol 3-O-β-D-glucuronide

CAS: 15270-30-1

Ref: 7W-GC1668

17β-Estradiol 3-β-D-Glucuronide

Controlled Product

CAS: 15270-30-1

Applications A metabolite of Estradiol (E888000).
References Agasan, A., et al.: J. Immunol. Methods., 177, 251 (1994), Stone, R., et al.: Science, 265, 308 (1994), Tacey, R., et al.: J. Pharm. Biomed. Anal., 2, 1303 (1994),

Formula: C₂₄H₃₂O₈

Color and Shape: White To Off-White

Molecular weight: 448.51

Ref: TR-E888010

Estradiol 3-glucuronide

CAS: 15270-30-1

Purity: 98%

Molecular weight: 448.21

Ref: 10-F553538

17β-Estradiol 3-β-D-glucuronide

CAS: 15270-30-1

17β-Estradiol 3-β-D-glucuronide is a metabolite of estradiol that is formed in the liver. It has been shown to have a high affinity for the estrogen receptor and can be used as a marker for chronic exposure to estradiol. 17β-Estradiol 3-β-D-glucuronide has also been shown to inhibit protein synthesis in mammalian cells by blocking the activity of the protein polymerase, which is required for cell division. This compound also binds to toll-like receptor 4 (TLR4), which may be due to its ability to induce cytokine production.

Formula: C₂₄H₃₂O₈

Purity: Min. 95%

Molecular weight: 448.5 g/mol

Ref: 3D-QAA27030

17β-Estradiol-3-β-D-Glucuronide

CAS: 15270-30-1

Formula: C₂₄H₃₂O₈

Molecular weight: 448.51

Ref: ST-EA-CP-E3023

17β-Estradiol-3-β-D-Glucuronide

CAS: 15270-30-1

Formula: C₂₄H₃₂O₈

Molecular weight: 448.51

Ref: ST-EA-CP-E28034

Estradiol 3-glucuronide

CAS: 15270-30-1

Estradiol 3-glucuronide is an immunogen with antigenic properties. The antiserum induced in rabbits exhibits high affinity and specificity for Estradiol 3-glucuronide. This compound shows promise for use in research involving radioimmunoassay.

Formula: C₂₄H₃₂O₈

Color and Shape: Solid

Molecular weight: 448.51

Ref: TM-T201862