CAS 152751-57-0

Sevelamer hydrochloride

Description:

Sevelamer hydrochloride is a polymeric compound primarily used as a phosphate binder in patients with chronic kidney disease who are on dialysis. It functions by binding dietary phosphate in the gastrointestinal tract, thereby reducing its absorption and helping to manage hyperphosphatemia. The substance is characterized by its high molecular weight and is non-absorbed, which means it does not enter systemic circulation. Sevelamer hydrochloride is typically administered orally in tablet or powder form and is known for its ability to lower serum phosphate levels without causing calcium overload, making it a preferred choice over calcium-based binders. Additionally, it has been associated with potential benefits in lipid profiles, as it may help lower LDL cholesterol levels. The compound is stable under normal conditions but should be stored in a cool, dry place to maintain its efficacy. As with any medication, it is essential to monitor for potential side effects, including gastrointestinal issues, and to adjust dosages as necessary based on individual patient needs.

Formula: (C₃H₇N·C₃H₅ClO·ClH)x

InChI: InChI=1S/C3H5ClO.C3H7N.ClH/c4-1-3-2-5-3;1-2-3-4;/h3H,1-2H2;2H,1,3-4H2;1H

InChI key: InChIKey=KHNXRSIBRKBJDI-UHFFFAOYSA-N

SMILES: C(CN)=C.Cl.C(Cl)C1CO1

Synonyms:

• 2-Propen-1-amine, hydrochloride, polymer with (chloromethyl)oxirane
• Allylamine hydrochloride-epichlorhydrin copolymer
• Allylamine hydrochloride-epichlorohydrin copolymer
• 2-Propen-1-amine, hydrochloride (1:1), polymer with 2-(chloromethyl)oxirane
• Oxirane, (chloromethyl)-, polymer with 2-propen-1-amine hydrochloride

Sevelamer Hydrochloride

CAS: 152751-57-0

Polysulfides, polysulfones & oth products spec in note 3, chapter 39, except elastomeric

Formula: (C₃H₇N)ab(C₉H₁₈N₂O)cn·xHCl

Color and Shape: White Off-White Powder

Ref: 45-1612460

Sevelamer hydrochloride

CAS: 152751-57-0

Sevelamer hydrochloride

Ref: 54-BUP15821

Sevelamer HCl

CAS: 152751-57-0

Color and Shape: Pale Yellow Solid

Ref: 4Z-S-221

Sevelamer hydrochloride

CAS: 152751-57-0

Sevelamer hydrochloride (Sevelamer HCl) is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption

Formula: (C₃H₇N·C₃H₅ClO·HCl)x

Purity: 98%

Color and Shape: Solid

Molecular weight: 186.08

Ref: TM-T6344

Sevelamer Hydrochloride (Technical Grade)

Controlled Product

CAS: 152751-57-0

Applications Sevelamer hydrochloride is a noncalcemic phosphate binder for the treatment of hyperphosphatemia in chronic renal failure or patients suffering from chronic kidney disease.
References Wells, K., et al.: Am. J. Psychiatry, 156, 5 (1999), Finn, W., et al.: Clin. Nephrol., 65, 191 (2006), Hutchison, A., et al.: Nephrol. Clin. Pract., 102, 61 (2006); Shavit, L. et al.: Clin. Nephrol., 78, 399 (2012); Daniel, G. et al.: Curr. Med. Res. Opin., 29,, 109 (2013);

Formula: (C₃H₇N)m•(C₃H₅ClO)n•(HCl)x

Color and Shape: Light Yellow

Ref: TR-S256000

2-Propen-1-amine, hydrochloride (1:1), polymer with 2-(chloromethyl)oxirane

CAS: 152751-57-0

Formula: C₆H₁₂ClNO

Color and Shape: Solid

Molecular weight: 149.6186

Ref: IN-DA002BGJ