CAS 15284-15-8

d-Methadone hydrochloride

Description:

d-Methadone hydrochloride is a synthetic opioid used primarily in the treatment of opioid dependence and chronic pain management. It is a racemic mixture, but the "d" prefix indicates the presence of the dextrorotatory isomer, which is more pharmacologically active. This compound acts as a mu-opioid receptor agonist, providing analgesic effects while also having a long half-life, which allows for once-daily dosing in maintenance therapy. d-Methadone hydrochloride is typically administered in the form of its hydrochloride salt, which enhances its solubility and stability. The substance is characterized by its white to off-white crystalline powder appearance and is soluble in water and alcohol. Its pharmacokinetics can vary significantly among individuals, influenced by factors such as metabolism and genetic variations. As with other opioids, there is a potential for abuse, dependence, and withdrawal symptoms, necessitating careful monitoring and regulation in clinical settings. Proper dosing and patient management are crucial to minimize risks associated with its use.

Formula: C₂₁H₂₈ClNO

InChI: InChI=1/C21H27NO.ClH/c1-5-20(23)21(16-17(2)22(3)4,18-12-8-6-9-13-18)19-14-10-7-11-15-19;/h6-15,17H,5,16H2,1-4H3;1H/t17-;/m0./s1

InChI key: InChIKey=FJQXCDYVZAHXNS-LMOVPXPDSA-N

SMILES: C(C[C@@H](N(C)C)C)(C(CC)=O)(C1=CC=CC=C1)C2=CC=CC=C2.Cl

Synonyms:

• (+)-6-(Dimethylamino)-4,4-diphenyl-3-heptanone Hydrochloride
• (+)-Methadone hydrochloride
• (S)-6-(Dimethylamino)-4,4-diphenyl-3-heptanone Hydrochloride
• (S)-Methadone hydrochloride
• 15284-15-8
• 3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-, hydrochloride (1:1), (6S)-
• 3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-, hydrochloride, (6S)-
• 3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-, hydrochloride, (S)-
• Dextromethadone Hydrochloride
• d-Amidone hydrochloride
• d-Dolophine hydrochloride

(S)-Methadone Hydrochloride (1 mg/ml in Methanol)

Controlled Product

CAS: 15284-15-8

Formula: C₂₁H₂₇NO·ClH

Color and Shape: Colourless

Molecular weight: 345.91

Ref: TR-KIT2530

(S)-Methadone Hydrochloride

Controlled Product

CAS: 15284-15-8

Applications A component of pharmaceuticals used in the treatment of opioid dependence.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Shiran, M., et al.: Brit. J. Clin. Pharmacol., 67, 29 (2008), Esteban, J., et al.: Drug Metab. Lett., 2, 269 (2008), Tolson, A., et al.: Drug Metab. Disposition, 37, 1887 (2009), Deeb, T., et al.: Mol. Pharmacol., 75, 908 (2009),

Formula: C₂₁H₂₇NO·ClH

Color and Shape: Neat

Molecular weight: 345.91

Ref: TR-M225885