CAS 152946-68-4: Nolatrexed dihydrochloride

Description: Nolatrexed dihydrochloride is a synthetic compound primarily recognized for its role as an antitumor agent. It functions as a folate antagonist, inhibiting dihydrofolate reductase, an enzyme critical for DNA synthesis and cell proliferation. This mechanism makes it particularly relevant in cancer therapy, as it disrupts the growth of rapidly dividing cells. The compound is typically presented as a dihydrochloride salt, which enhances its solubility in aqueous solutions, facilitating its administration in clinical settings. Nolatrexed dihydrochloride exhibits a moderate to high level of stability under standard conditions, although it should be stored in a cool, dry place to maintain its integrity. Its pharmacokinetics involve absorption, distribution, metabolism, and excretion processes that are essential for determining its therapeutic efficacy and safety profile. As with many chemotherapeutic agents, potential side effects may include myelosuppression and gastrointestinal disturbances, necessitating careful monitoring during treatment. Overall, Nolatrexed dihydrochloride represents a significant compound in the field of oncology, contributing to the arsenal of drugs available for cancer management.

Formula: C₁₄H₁₂N₄OS·2ClH

InChI: InChI=1S/C14H12N4OS.2ClH/c1-8-2-3-10-11(13(19)18-14(15)17-10)12(8)20-9-4-6-16-7-5-9;;/h2-7H,1H3,(H3,15,17,18,19);2*1H

InChI key: InChIKey=PJKVJJYMWOCLIJ-UHFFFAOYSA-N

SMILES: Cl.O=C1N=C(N)NC2=CC=C(C(SC=3C=CN=CC3)=C12)C

Synonyms:

• 2-Amino-6-methyl-5-(4-pyridinylthio)-4(1H)-quinazolinone Hydrochloride
• 3,4-Dihydro-2-Amino-6-Methyl-4-Oxo-5-(4-Pyridylthio)-Quinazoline Dihydrochloride
• 4(1H)-Quinazolinone, 2-amino-6-methyl-5-(4-pyridinylthio)-, dihydrochloride
• 4(1H)-Quinazolinone, 2-amino-6-methyl-5-(4-pyridinylthio)-, hydrochloride (1:2)
• Ag 337
• Nolatrexed 2Hcl
• Nolatrexed Hcl
• Thymitaq
• Nolatrexed dihydrochloride

Nolatrexed dihydrochloride

CAS: 152946-68-4

Nolatrexed dihydrochloride (Thymitaq) is a soluble, lipophilic cancer drug that inhibits DNA replication, causing cell …

• Formula: C₁₄H₁₄Cl₂N₄OS
• Purity: 97.02%
• Color and Shape: Tan Solid
• Molecular weight: 357.26

Nolatrexed dihydrochloride

CAS: 152946-68-4

• Formula: C₁₄H₁₄Cl₂N₄OS
• Purity: ≥ 96.0%
• Color and Shape: White to light-yellow powder
• Molecular weight: 357.26

Nolatrexed dihydrochloride

CAS: 152946-68-4

Thymidylate synthase inhibitor

• Formula: C₁₄H₁₄Cl₂N₄OS
• Purity: Min. 95%
• Color and Shape: White To Light (Or Pale) Yellow Solid
• Molecular weight: 357.26 g/mol

Nolatrexed Dihydrochloride

CAS: 152946-68-4

• Formula: C₁₄H₁₂N₄OSClH
• Color and Shape: Neat
• Molecular weight: 357.26