CAS 153050-21-6

1-{2-[(3S)-3-(3,4-dichlorophenyl)-1-{[3-(propan-2-yloxy)phenyl]acetyl}piperidin-3-yl]ethyl}-4-phenyl-1-azoniabicyclo[2.2.2]octane chloride

Description:

The chemical substance known as 1-{2-[(3S)-3-(3,4-dichlorophenyl)-1-{[3-(propan-2-yloxy)phenyl]acetyl}piperidin-3-yl]ethyl}-4-phenyl-1-azoniabicyclo[2.2.2]octane chloride, with the CAS number 153050-21-6, is a complex organic compound characterized by its bicyclic structure and quaternary ammonium nature due to the presence of the azabicyclo[2.2.2]octane moiety. This compound features multiple functional groups, including a piperidine ring and various aromatic systems, which contribute to its potential biological activity. The presence of chlorine substituents on the phenyl ring may influence its pharmacological properties, possibly enhancing its interaction with biological targets. As a quaternary ammonium compound, it is likely to exhibit ionic characteristics, affecting its solubility and reactivity in different environments. Such compounds are often investigated for their potential therapeutic applications, particularly in the fields of medicinal chemistry and drug development. However, specific details regarding its biological activity, toxicity, and applications would require further empirical studies and literature review.

Formula: C₃₇H₄₅Cl₃N₂O₂

InChI: InChI=1/C37H45Cl2N2O2.ClH/c1-28(2)43-32-11-6-8-29(24-32)25-35(42)40-19-7-14-37(27-40,31-12-13-33(38)34(39)26-31)18-23-41-20-15-36(16-21-41,17-22-41)30-9-4-3-5-10-30;/h3-6,8-13,24,26,28H,7,14-23,25,27H2,1-2H3;1H/q+1;/p-1/t36?,37-,41?;/m1./s1

Synonyms:

• 1-azoniabicyclo[2.2.2]octane, 1-[2-[(3S)-3-(3,4-dichlorophenyl)-1-[2-[3-(1-methylethoxy)phenyl]acetyl]-3-piperidinyl]ethyl]-4-phenyl-, chloride (1:1)

SR 140333

CAS: 153050-21-6

SR140333 is a novel, potent and selective antagonist of the neurokinin-1 receptor (NK1R). The drug has shown efficacy in animal models of chronic cough, bowel disease, and tachykinin-mediated disorders. SR140333 has been shown to decrease locomotor activity and suppress the rotarod test in mice. The drug also has an effect on brain functions such as learning and memory.

Formula: C₃₇H₄₅Cl₃N₂O₂

Purity: Min. 95%

Molecular weight: 656.1 g/mol

Ref: 3D-DGA05021

SR 140333

CAS: 153050-21-6

SR 140333 is a NK1 receptor antagonist.

Formula: C₃₇H₄₅Cl₃N₂O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 656.12

Ref: TM-T23385