CAS 153168-05-9
:PLECONARIL
Description:
Pleconaril is an antiviral compound primarily known for its activity against enteroviruses and rhinoviruses, which are responsible for various respiratory infections. It functions by inhibiting viral replication, specifically targeting the viral capsid, thereby preventing the uncoating process necessary for viral entry into host cells. Pleconaril is characterized by its relatively low solubility in water, which can affect its bioavailability and formulation in pharmaceutical applications. The compound has a molecular weight that classifies it as a small molecule, and it exhibits a moderate lipophilicity, allowing for potential oral bioavailability. Its chemical structure includes a pyridine ring and a cyclopropane moiety, contributing to its unique pharmacological properties. While pleconaril has shown promise in clinical trials for treating viral infections, its use has been limited due to concerns about resistance and the need for further studies to establish its efficacy and safety profile in broader patient populations. Overall, pleconaril represents a significant area of interest in antiviral research, particularly for respiratory viral infections.
Formula:C18H18F3N3O3
InChI:InChI=1/C18H18F3N3O3/c1-10-7-13(16-22-17(27-24-16)18(19,20)21)8-11(2)15(10)25-6-4-5-14-9-12(3)23-26-14/h7-9H,4-6H2,1-3H3
InChI key:InChIKey=KQOXLKOJHVFTRN-UHFFFAOYSA-N
SMILES:C(F)(F)(F)C1=NC(=NO1)C2=CC(C)=C(OCCCC3=CC(C)=NO3)C(C)=C2
Synonyms:- 1,2,4-Oxadiazole, 3-[3,5-dimethyl-4-[3-(3-methyl-5-isoxazolyl)propoxy]phenyl]-5-(trifluoromethyl)-
- 3-[3,5-Dimethyl-4-[3-(3-methyl-5-isoxazolyl)propoxy]phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole
- 3-{3,5-Dimethyl-4-[3-(3-Methyl-1,2-Oxazol-5-Yl)Propoxy]Phenyl}-5-(Trifluoromethyl)-1,2,4-Oxadiazole
- Picovir
- Vp 63843
- Win 63843
- Pleconaril
- Rimiducid
- 3-[3,5-DiMethyl-4-[3-(3-Methyl-5-isoxazolyl)propoxy]phenyl]-5-(trifluoroMethyl)-
- Pleconarilis
- 3-(3,5-dimethyl-4-(3-(3-methylisoxazol-5-yl)propoxy)phenyl)-5-(trifluoromethyl)-1,2,4-oxadiazole
- PLECONARIL USP/EP/BP
- See more synonyms
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Found 13 products.
Pleconaril-d4
CAS:Formula:C18H14F3N3O3D4Color and Shape:White To Off-White SolidMolecular weight:385.383-(3,5-Dimethyl-4-(3-(3-Methylisoxazol-5-Yl)Propoxy)Phenyl)-5-(Trifluoromethyl)-1,2,4-Oxadiazole
CAS:<p>3-(3,5-Dimethyl-4-(3-(3-Methylisoxazol-5-Yl)Propoxy)Phenyl)-5-(Trifluoromethyl)-1,2,4-Oxadiazole</p>Purity:98%Molecular weight:381.35g/molPleconaril
CAS:<p>Pleconaril (VP 63843) is a capsid inhibitor used previously to treat enterovirus infections. Pleconaril is effective in inhibiting replication (IC50: 50 nM).</p>Formula:C18H18F3N3O3Purity:98.21% - 99.09%Color and Shape:SolidMolecular weight:381.35Pleconaril
CAS:Controlled Product<p>Applications Picornavirus replication inhibitor. Antiviral.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kearns, G.L., J. Clin. Pharmacol., 39, 613 (1999), Schmidtke, M. et al.: Antiviral Res. 81, 56 (2009)<br></p>Formula:C18H18F3N3O3Color and Shape:NeatMolecular weight:381.35Pleconaril
CAS:<p>Anti-viral; capsid inhibitor</p>Formula:C18H18F3N3O3Purity:Min. 98 Area-%Color and Shape:White PowderMolecular weight:381.35 g/molPleconaril - Bio-X ™
CAS:<p>This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>Formula:C18H18F3N3O3Purity:Min. 95%Color and Shape:PowderMolecular weight:381.35 g/mol
