CAS 153205-46-0

Asimadoline

Description:

Asimadoline is a chemical compound primarily recognized for its role as a selective kappa-opioid receptor agonist. It is classified under the category of non-opioid analgesics and has been investigated for its potential therapeutic applications, particularly in the management of pain and gastrointestinal disorders. The compound exhibits a unique mechanism of action by selectively targeting kappa-opioid receptors, which are part of the opioid receptor family, influencing pain perception and emotional responses without the typical side effects associated with traditional opioids. Asimadoline has been studied in various clinical settings, including its effects on conditions like irritable bowel syndrome. Its pharmacological profile suggests a lower risk of addiction and respiratory depression compared to conventional opioids, making it a subject of interest in pain management research. However, further studies are necessary to fully understand its efficacy, safety, and potential applications in clinical practice.

Formula: C₂₇H₃₀N₂O₂

InChI: InChI=1S/C27H30N2O2/c1-28(25(21-11-5-2-6-12-21)20-29-18-17-24(30)19-29)27(31)26(22-13-7-3-8-14-22)23-15-9-4-10-16-23/h2-16,24-26,30H,17-20H2,1H3/t24-,25+/m0/s1

InChI key: InChIKey=JHLHNYVMZCADTC-LOSJGSFVSA-N

SMILES: C(C(N([C@H](CN1CC[C@H](O)C1)C2=CC=CC=C2)C)=O)(C3=CC=CC=C3)C4=CC=CC=C4

Synonyms:

• Asimadoline [INN]
• Benzeneacetamide, N-((1S)-2-((3S)-3-hydroxy-1-pyrrolidinyl)-1-phenylethyl)-N-methyl-alpha-phenyl-
• Benzeneacetamide, N-(2-(3-hydroxy-1-pyrrolidinyl)-1-phenylethyl)-N-methyl-alpha-phenyl-, (S-(R*,R*))-
• Benzeneacetamide, N-[(1S)-2-[(3S)-3-hydroxy-1-pyrrolidinyl]-1-phenylethyl]-N-methyl-α-phenyl-
• Benzeneacetamide, N-[2-(3-hydroxy-1-pyrrolidinyl)-1-phenylethyl]-N-methyl-α-phenyl-, [S-(R*,R*)]-
• Emd 61753
• N-((alpha S)-alpha-((3S)-3-Hydroxy-1-pyrrolidinyl)methyl)benzyl)-N-methyl-2,2-diphenylacetamide
• N-((alphaS)-alpha-(((3S)-3-Hydroxy-1-pyrrolidinyl)methyl)benzyl)-N-methyl-2,2-diphenylacetamide
• N-[(1S)-2-[(3S)-3-Hydroxy-1-pyrrolidinyl]-1-phenylethyl]-N-methyl-α-phenylbenzeneacetamide
• N-{(1S)-2-[(3S)-3-hydroxypyrrolidin-1-yl]-1-phenylethyl}-N-methyl-2,2-diphenylacetamide
• Unii-D0Vk52Nv5M

Asimadoline

CAS: 153205-46-0

Formula: C₂₇H₃₀N₂O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 414.5393

Ref: IN-DA00APIH

Asimadoline

CAS: 153205-46-0

Asimadoline (EMD-61753) is a proprietary small molecule therapeutic, originally discovered by Merck KGaA of Darmstadt, Germany.

Formula: C₂₇H₃₀N₂O₂

Color and Shape: Solid

Molecular weight: 414.54

Ref: TM-T4633

Asimadoline

CAS: 153205-46-0

Formula: C₂₇H₃₀N₂O₂

Molecular weight: 414.55

Ref: 4Z-A-210001

Asimadoline

CAS: 153205-46-0

Asimadoline is a compound that has been shown to have analgesic and anti-inflammatory effects. It binds to κ-opioid receptors, which are found in the central nervous system and gastrointestinal tract. Asimadoline also binds to kappa-opioid receptors, which are located on immune cells in the brain and spinal cord. This drug has been shown to inhibit the production of pro-inflammatory cytokines, such as TNF-α and IL-1β, which may be due to activation of κ-opioid receptors. Asimadoline has also been shown to inhibit Pgp substrate activity, which may explain its ability to treat bowel disease, primary sclerosing cholangitis (PSC), inflammatory bowel disease (IBD), diabetic neuropathy, and antinociceptive disorders.

Formula: C₂₇H₃₀N₂O₂

Purity: Min. 95%

Molecular weight: 414.54 g/mol

Ref: 3D-DGA20546

Asimadoline

CAS: 153205-46-0

Formula: C₂₇H₃₀N₂O₂

Molecular weight: 414.55

Ref: ST-EA-CP-A309000