CAS 153259-65-5

Cilomilast

Description:

Cilomilast is a selective phosphodiesterase-4 (PDE4) inhibitor, primarily investigated for its potential therapeutic applications in respiratory diseases, particularly chronic obstructive pulmonary disease (COPD) and asthma. As a small organic molecule, Cilomilast functions by inhibiting the breakdown of cyclic adenosine monophosphate (cAMP), leading to increased levels of cAMP within cells. This mechanism promotes anti-inflammatory effects and bronchodilation, making it beneficial in managing airway inflammation. Cilomilast is characterized by its moderate solubility in water and its ability to penetrate biological membranes, which is crucial for its pharmacological activity. The compound has undergone various clinical trials to assess its efficacy and safety profile, although it has not been widely adopted in clinical practice. Its chemical structure includes specific functional groups that contribute to its biological activity and selectivity for PDE4 over other phosphodiesterases. Overall, Cilomilast represents a class of drugs aimed at modulating inflammatory pathways in respiratory conditions, although its clinical use may be limited compared to other available therapies.

Formula: C₂₀H₂₅NO₄

InChI: InChI=1/C20H25NO4/c1-24-17-7-6-15(12-18(17)25-16-4-2-3-5-16)20(13-21)10-8-14(9-11-20)19(22)23/h6-7,12,14,16H,2-5,8-11H2,1H3,(H,22,23)/t14-,20-

InChI key: InChIKey=CFBUZOUXXHZCFB-OYOVHJISNA-N

SMILES: C(#N)[C@]1(CC[C@@H](C(O)=O)CC1)C2=CC(OC3CCCC3)=C(OC)C=C2

Synonyms:

• 4-Cyano-4-(3-Cyclopentyloxy-4-Methoxy-Phenyl)Cyclohexane-1-Carboxylic Acid
• 4-Cyano-4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]Cyclohexanecarboxylic Acid
• Ariflo
• Cilomelast
• Clomilast
• Cyclohexanecarboxylic acid, 4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]-, cis-
• Sb 207499
• cis-4-Cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]-cyclohexanecarboxylic Acid
• cis-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-4-cyanocyclohexane-1-carboxylic Acid

Cilomilast

CAS: 153259-65-5

Formula: C₂₀H₂₅NO₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 343.4168

Ref: IN-DA00AOPF

Cilomilast

CAS: 153259-65-5

Formula: C₂₀H₂₅NO₄

Molecular weight: 343.42

Ref: 7W-GP2387

Cilomilast

CAS: 153259-65-5

Cilomilast

Purity: ≥95%

Molecular weight: 343.42g/mol

Ref: 54-BUP10699

Cilomilast

CAS: 153259-65-5

Cilomilast (SB-207499) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. Phase 3.

Formula: C₂₀H₂₅NO₄

Purity: 97.37% - 99.52%

Color and Shape: White Solid

Molecular weight: 343.42

Ref: TM-T6445