CAS 1534-35-6

Isolithocholic acid

Description:

Isolithocholic acid, with the CAS number 1534-35-6, is a bile acid derivative that is structurally related to lithocholic acid. It is characterized by its steroidal structure, which consists of a four-ring core typical of steroid compounds. Isolithocholic acid is known for its hydrophobic properties, which influence its solubility and interaction with biological membranes. This compound plays a role in the digestion and absorption of dietary fats and fat-soluble vitamins in the intestine. Additionally, it is involved in the regulation of cholesterol metabolism and has been studied for its potential effects on various physiological processes, including its influence on gut microbiota and metabolic pathways. Isolithocholic acid can be synthesized from cholesterol through a series of enzymatic reactions in the liver. Its biological activity and potential therapeutic applications are areas of ongoing research, particularly in relation to metabolic disorders and liver function. As with many bile acids, its concentration and balance are crucial for maintaining overall health.

Formula: C₂₄H₄₀O₃

InChI: InChI=1S/C24H40O3/c1-15(4-9-22(26)27)19-7-8-20-18-6-5-16-14-17(25)10-12-23(16,2)21(18)11-13-24(19,20)3/h15-21,25H,4-14H2,1-3H3,(H,26,27)/t15-,16-,17+,18+,19-,20+,21+,23+,24-/m1/s1

InChI key: InChIKey=SMEROWZSTRWXGI-WFVDQZAMSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](CC3)(C[C@@H](O)CC4)[H])(CC1)[H])[H])(CC[C@@]2([C@@H](CCC(O)=O)C)[H])[H]

Synonyms:

• (3beta,5beta)-3-Hydroxycholan-24-oic acid
• (3β,5β)-3-Hydroxycholan-24-oic acid
• 3-Epilithocholic acid
• 3β-Hydroxy-5β-cholan-24-oic acid
• 3β-Hydroxy-5β-cholanic acid
• 3β-Hydroxy-5β-cholanoic acid
• 3β-Lithocholic acid
• 5β-Cholan-24-oic acid, 3β-hydroxy-
• 5β-Cholanic acid, 3β-hydroxy-
• 5β-Cholanic acid-3β-ol
• Cholan-24-oic acid, 3-hydroxy-, (3beta,5beta)-
• Cholan-24-oic acid, 3-hydroxy-, (3β,5β)-
• Isolithocholic acid
• β-Lithocholanic acid

Isolithocholic Acid

CAS: 1534-35-6

Formula: C₂₄H₄₀O₃

Molecular weight: 376.58

Ref: 4Z-L-1817

Isolithocholic Acid

CAS: 1534-35-6

Isolithocholic Acid

Purity: ≥98%

Molecular weight: 376.57g/mol

Ref: 54-BUP07131

Isolithocholic acid

CAS: 1534-35-6

Formula: C24H40O3

Purity: >99%

Color and Shape: Solid

Molecular weight: 376.57

Ref: 48-65-1101

Isolithocholic Acid-d5

CAS: 1534-35-6

Formula: C₂₄H₃₅D₅O₃

Molecular weight: 381.61

Ref: 4Z-L-1818

(3β,5β)-3-Hydroxycholan-24-oic acid

CAS: 1534-35-6

Applications (3β,5β)-3-Hydroxycholan-24-oic acid has been used for the study of the activation of β1 subunit-​containing BK channels with respect to the structure of monohydroxylated bile acids.
References Bukiya, A.N., ey al.: J. Lipid. Res., 49, 2441-2451 (2008)

Formula: C₂₄H₄₀O₃

Color and Shape: Neat

Molecular weight: 376.57

Ref: TR-H824865

Isolithocholic acid

Controlled Product

CAS: 1534-35-6

Isolithocholic acid is a bile acid derivative, which is a secondary bile acid formed by the action of intestinal bacteria. Its source lies primarily in the microbial metabolism of primary bile acids within the digestive tract. Isolithocholic acid's mode of action involves interaction with nuclear receptors such as the Farnesoid X receptor (FXR), which play critical roles in the regulation of bile acid, lipid, and glucose metabolism.

Formula: C₂₄H₄₀O₃

Purity: Min. 95%

Molecular weight: 376.6 g/mol

Ref: 3D-FH179942

Isolithocholic Acid

CAS: 1534-35-6

Isolithocholic Acid, a bile acid isomer, forms through microbial metabolism of Lithocholic acid or its 3α-sulfate.

Formula: C₂₄H₄₀O₃

Purity: 99.56% - 99.84%

Color and Shape: Solid

Molecular weight: 376.57

Ref: TM-T35792