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CAS 153408-27-6

:

azelastine hydrochloride

Description:
Azelastine hydrochloride is a potent antihistamine primarily used in the treatment of allergic rhinitis and conjunctivitis. It functions as a selective H1 receptor antagonist, effectively blocking the action of histamine, a key mediator in allergic responses. This compound is characterized by its ability to provide rapid relief from allergy symptoms such as sneezing, itching, and nasal congestion. Azelastine hydrochloride is typically administered via nasal spray or eye drops, allowing for localized action with minimal systemic absorption. The substance is known for its relatively low solubility in water, which can influence its formulation in pharmaceutical products. Additionally, it exhibits a favorable safety profile, with common side effects being mild and transient. The chemical structure of azelastine includes a phthalazinone moiety, contributing to its pharmacological properties. Overall, azelastine hydrochloride is a valuable therapeutic agent in managing allergic conditions, offering both efficacy and convenience in administration.
Formula:C22H24ClN3O·HCl
InChI:InChI=1/C22H24ClN3O.ClH/c1-25-13-4-5-18(12-14-25)26-22(27)20-7-3-2-6-19(20)21(24-26)15-16-8-10-17(23)11-9-16;/h2-3,6-11,18H,4-5,12-15H2,1H3;1H/t18-;/m1./s1
SMILES:CN1CCC[C@H](CC1)n1c(=O)c2ccccc2c(Cc2ccc(cc2)Cl)n1.Cl
Synonyms:
  • 1(2H)-Phthalazinone, 4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-, monohydrochloride, (S)-
  • 4-(4-chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one hydrochloride (1:1)
  • (S)-4-[(4-Chlorophenyl)Methyl]-2-(hexahydro-1-Methyl-1H-azepin-4-yl)-1(2H)-phthalazinone Hydrochloride
  • Azelastine Impurity
  • (S)-Azelastine HCl
  • (S)-Azelastine Hydrochloride 2
  • (S)-Azelastine Hydrochloride
  • Azelastine Impurity 2
  • (S)-Azelastine Hydrochloride USP/EP/BP
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Found 3 products.
  • (S)-Azelastine HCl
    TLC
    + Info

    (S)-Azelastine HCl

    CAS:
    Formula:C22H25Cl2N3O
    Color and Shape:White To Off-White Solid
    Molecular weight:418.36

    Ref: 4Z-A-682

    5mg
    To inquire
    10mg
    910.00€
    25mg
    1,638.00€
    50mg
    2,366.00€
    100mg
    To inquire
  • (S)-Azelastine hydrochloride
    Targetmol
    + Info

    (S)-Azelastine hydrochloride

    CAS:
    (S)-Azelastine HCl, an antihistamine, reduces H1R, M1R, M3R levels and inhibits HNEpC growth.
    Formula:C22H25Cl2N3O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:418.36

    Ref: TM-T21109

  • (S)-Azelastine Hydrochloride
    TRC
    + Info

    (S)-Azelastine Hydrochloride

    Controlled Product
    CAS:
    <p>Applications Orally active H1-hystamine receptor antagonist. Antihistaminic.<br>References Tasaka, K., et al.: Arzneim.-Forsch., 29, 488 (1979), Chand, N., et al.: Int. J. Immunopharmacol., 7, 833 (1985),<br></p>
    Formula:C22H24ClN3O·ClH
    Color and Shape:Neat
    Molecular weight:418.36

    Ref: TR-A808246

    10mg
    1,029.00€