CAS 153408-28-7

azelastine hydrochloride

Description:

Azelastine hydrochloride is a pharmaceutical compound primarily used as an antihistamine for the treatment of allergic rhinitis and conjunctivitis. It is classified as a selective H1 receptor antagonist, which helps alleviate symptoms such as sneezing, itching, and nasal congestion by blocking the action of histamine, a substance in the body that causes allergic symptoms. The compound is typically administered as a nasal spray or eye drops, allowing for localized treatment with minimal systemic absorption. Azelastine hydrochloride is characterized by its relatively low solubility in water, which can influence its formulation and delivery methods. Additionally, it exhibits a rapid onset of action, making it effective for acute allergic reactions. The substance has a molecular formula that reflects its complex structure, contributing to its pharmacological properties. As with many medications, potential side effects may include drowsiness, dry mouth, or local irritation, necessitating careful consideration during use. Overall, azelastine hydrochloride is a valuable agent in managing allergic conditions, providing relief for many patients.

Formula: C₂₂H₂₅Cl₂N₃O

InChI: InChI=1/C22H24ClN3O.ClH/c1-25-13-4-5-18(12-14-25)26-22(27)20-7-3-2-6-19(20)21(24-26)15-16-8-10-17(23)11-9-16;/h2-3,6-11,18H,4-5,12-15H2,1H3;1H/t18-;/m1./s1

SMILES: CN1CCC[C@H](CC1)n1c(=O)c2ccccc2c(Cc2ccc(cc2)Cl)n1.Cl

Synonyms:

• 1(2H)-Phthalazinone, 4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-, monohydrochloride, (S)-
• 4-(4-chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one hydrochloride (1:1)

(R)-Azelastine HCl

CAS: 153408-28-7

Formula: C₂₂H₂₄ClN₃O·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 381.91 36.46

Ref: 4Z-A-681

(R)-Azelastine Hydrochloride

Controlled Product

CAS: 153408-28-7

Applications Orally active H1-hystamine receptor antagonist. Antihistaminic.
References Tasaka, K., et al.: Arzneim.-Forsch., 29, 488 (1979), Chand, N., et al.: Int. J. Immunopharmacol., 7, 833 (1985),

Formula: C₂₂H₂₅Cl₂N₃O

Color and Shape: Off-White

Molecular weight: 418.36

Ref: TR-A808245

(R)-Azelastine hydrochloride

CAS: 153408-28-7

(R)-Azelastine hydrochloride is an isomer of Azelastine hydrochloride, suitable for biochemical experiments and drug synthesis research.

Formula: C₂₂H₂₅Cl₂N₃O

Purity: 99.99%

Color and Shape: Solid

Molecular weight: 418.36

Ref: TM-T70481