CAS 153415-45-3

Taxol C

Description:

Taxol C, also known by its chemical name as a derivative of paclitaxel, is a complex natural product primarily derived from the bark of the Pacific yew tree (Taxus brevifolia). It is classified as an antineoplastic agent, commonly used in cancer therapy, particularly for ovarian and breast cancers. The compound exhibits a unique mechanism of action by stabilizing microtubules and preventing their depolymerization, which disrupts normal cell division and leads to apoptosis in rapidly dividing cancer cells. Taxol C has a specific molecular structure characterized by a taxane core, which includes a bicyclic ring system and various functional groups that contribute to its biological activity. Its solubility is limited in water, necessitating the use of solvents or formulations for therapeutic applications. Additionally, Taxol C has been studied for its potential in overcoming drug resistance in cancer treatments. As with many chemotherapeutic agents, it may have side effects, including immunosuppression and neuropathy, which necessitate careful monitoring during treatment.

Formula: C₄₆H₅₇NO₁₄

InChI: InChI=1S/C46H57NO14/c1-8-9-12-21-33(51)47-35(28-17-13-10-14-18-28)36(52)42(55)59-30-23-46(56)40(60-41(54)29-19-15-11-16-20-29)38-44(7,31(50)22-32-45(38,24-57-32)61-27(4)49)39(53)37(58-26(3)48)34(25(30)2)43(46,5)6/h10-11,13-20,30-32,35-38,40,50,52,56H,8-9,12,21-24H2,1-7H3,(H,47,51)/t30-,31-,32+,35-,36+,37+,38-,40-,44+,45-,46+/m0/s1

InChI key: InChIKey=BEHTXUBGUDGCNQ-IEAAAIHOSA-N

SMILES: O(C(C)=O)[C@]12[C@]3([C@H](OC(=O)C4=CC=CC=C4)[C@@]5(O)C(C)(C)C([C@@H](OC(C)=O)C(=O)[C@]3(C)[C@@H](O)C[C@]1(OC2)[H])=C(C)[C@@H](OC([C@@H]([C@@H](NC(CCCCC)=O)C6=CC=CC=C6)O)=O)C5)[H]

Synonyms:

• (-)-Taxuyunnanine
• (2alpha,5beta,7beta,10beta,13alpha)-4,10-bis(acetyloxy)-13-{[(2R,3S)-3-(hexanoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,7-dihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
• 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
• Benzenepropanoic acid, α-hydroxy-β-[(1-oxohexyl)amino]-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
• Benzenepropanoic acid, α-hydroxy-β-[(1-oxohexyl)amino]-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-
• Paclitaxel C
• Taxuyunnanine A
• benzenepropanoic acid, alpha-hydroxy-beta-[(1-oxohexyl)amino]-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (alphaR,betaS)-
• Taxol C

PACLITAXEL IMPURITY C CRS

CAS: 153415-45-3

PACLITAXEL IMPURITY C CRS

Formula: C₄₆H₅₇NO₁₄

Molecular weight: 847.9431

Ref: 41-Y0000699

Paclitaxel EP Impurity C

CAS: 153415-45-3

Formula: C₄₆H₅₇NO₁₄

Color and Shape: White To Off-White Solid

Molecular weight: 847.96

Ref: 4Z-P-2816

Taxol C

CAS: 153415-45-3

Taxol C

Purity: ≥98%

Molecular weight: 847.94g/mol

Ref: 54-BUP00746

Taxol C

CAS: 153415-45-3

Formula: C₄₆H₅₇NO₁₄

Purity: 95%~99%

Molecular weight: 847.955

Ref: BP-SBP04368

Taxol C

CAS: 153415-45-3

Taxol C can reduce interaction with the P-glycoprotein transporter that may allow for increased permeation of taxanes into the brain.

Formula: C₄₆H₅₇NO₁₄

Purity: 99.18%

Color and Shape: Solid

Molecular weight: 847.94

Ref: TM-TN5118

Paclitaxel C

Controlled Product

CAS: 153415-45-3

Formula: C₄₆H₅₇NO₁₄

Color and Shape: Neat

Molecular weight: 847.94

Ref: TR-P132510

N-Debenzoyl-N-hexanoylpaclitaxel

CAS: 153415-45-3

N-Debenzoyl-N-hexanoylpaclitaxel (DHBPTx) is an analog of paclitaxel. It inhibits cell proliferation by binding to the diketone group at the C-10 position of baccatin III, which inhibits the synthesis of taxol and other natural products with a diketone group at this position. DHBPTx is effective against colorectal carcinoma cells in culture, but has not been tested in vivo. This drug has also been shown to be effective against breast cancer cells that express high levels of 10-deacetylase activity. It is metabolized into 10-deacetylbaccatin III, which binds to cellular protein kinase C and causes inhibition of mitosis and apoptosis. In addition, DHBPTx can be conjugated with other drugs such as doxorubicin or vincristine to increase their effectiveness.

Formula: C₄₆H₅₇NO₁₄

Purity: Min. 95%

Molecular weight: 847.94 g/mol

Ref: 3D-ID26723

Paclitaxel EP Impurity C

CAS: 153415-45-3

Formula: C₄₆H₅₇NO₁₄

Molecular weight: 847.95

Ref: ST-EA-CP-P36001