CAS 153436-38-5

1H-Indole-2-carboxylicacid, 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-, monosodium salt(9CI)

Description:

1H-Indole-2-carboxylic acid, 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-, monosodium salt (CAS 153436-38-5) is a chemical compound characterized by its indole core structure, which is a bicyclic compound consisting of a benzene ring fused to a pyrrole ring. The presence of carboxylic acid and dichloro substituents indicates potential for reactivity and interaction with biological systems. The compound features a phenylamino group, suggesting it may exhibit significant biological activity, possibly as an inhibitor or modulator in various biochemical pathways. The monosodium salt form enhances its solubility in aqueous environments, making it more bioavailable for pharmacological applications. This compound may be of interest in medicinal chemistry and drug development due to its structural complexity and potential therapeutic properties. Its specific interactions and mechanisms of action would require further investigation through experimental studies.

Formula: C₁₈H₁₃Cl₂N₂NaO₃

InChI: InChI=1S/C18H12Cl2N2O3.Na/c19-10-8-13(20)16-12(17(18(24)25)22-14(16)9-10)6-7-15(23)21-11-4-2-1-3-5-11;/h1-9,22H,(H,21,23)(H,24,25);/b7-6+;

InChI key: InChIKey=OBPMZHMRJJJUBC-UHDJGPCESA-N

SMILES: C(=C/C(NC1=CC=CC=C1)=O)\C=2C=3C(NC2C(O)=O)=CC(Cl)=CC3Cl.[Na]

Synonyms:

• 1H-Indole-2-carboxylic acid, 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propen-1-yl]-, sodium salt (1:1)
• 1H-Indole-2-carboxylic acid, 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-, monosodium salt
• 1H-Indole-2-carboxylic acid, 4,6-dichloro-3-[3-oxo-3-(phenylamino)-1-propenyl]-, monosodium salt, (E)-
• 1H-Indole-2-carboxylicacid, 4,6-dichloro-3-[3-oxo-3-(phenylamino)-1-propenyl]-, monosodium salt,(E)-
• Gv 150526A
• Gavestinel sodium salt

Gavestinel (sodium salt)

CAS: 153436-38-5

Formula: C₁₈H₁₁Cl₂N₂NaO₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 397.1873

Ref: IN-DA00B0US

Gavestinel sodium

CAS: 153436-38-5

Gavestinel sodium

Purity: ≥98%

Molecular weight: 397.19g/mol

Ref: 54-BUP03876

Gavestinel

Controlled Product

CAS: 153436-38-5

Applications Gavestinel is a potent, selective, and non competitive NMDA receptor antagonist.

Formula: C₁₈H₁₁Cl₂N₂NaO₃

Color and Shape: Neat

Molecular weight: 397.19

Ref: TR-G596618

Gavestinel

CAS: 153436-38-5

Gavestinel is a novel anti-platelet agent that is undergoing clinical trials for the treatment of stroke. Gavestinel binds to and blocks the P2Y12 receptor in platelets, which inhibits platelet aggregation and prevents formation of blood clots. In addition to its anti-platelet effects, gavestinel also has been shown to protect neurons against ischemic brain damage. This protection is likely due to the inhibition of neuronal death by cation channels and protein transport, as well as an increase in the release of gamma-aminobutyric acid (GABA) from GABAergic neurons. Gavestinel also inhibits glutamate release from the presynaptic neuron, leading to less excitotoxicity at postsynaptic sites. The mechanism of action has been elucidated using kinetic data obtained from binding assays with recombinant proteins. Gavestinel is also an inhibitor of ATP channels that are found in many types of cells, including glial cells.

Formula: C₁₈H₁₁Cl₂N₂NaO₃

Purity: Min. 95%

Molecular weight: 397.19 g/mol

Ref: 3D-DGA43638

Gavestinel sodium

CAS: 153436-38-5

Gavestinel (GV 150526): potent, selective oral NMDA antagonist; binds glycine site, pKi 8.5; studied for acute ischemic stroke.

Formula: C₁₈H₁₁Cl₂N₂NaO₃

Purity: 99.04%

Color and Shape: Solid

Molecular weight: 397.19

Ref: TM-T22798