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CAS 153438-49-4

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Dapitant

Description:
Dapitant, with the CAS number 153438-49-4, is a chemical compound that belongs to the class of neurokinin-1 (NK1) receptor antagonists. It is primarily investigated for its potential therapeutic applications in the treatment of various conditions, including anxiety and depression, as well as for its antiemetic properties in chemotherapy-induced nausea and vomiting. Dapitant functions by blocking the action of substance P, a neuropeptide associated with pain perception and stress responses, thereby modulating neurogenic inflammation and other related pathways. The compound is characterized by its specific binding affinity to NK1 receptors, which are widely distributed in the central nervous system and peripheral tissues. Its pharmacological profile suggests a favorable safety and efficacy balance, although detailed clinical data may vary. As with many investigational drugs, ongoing research is essential to fully elucidate its mechanism of action, therapeutic potential, and any associated side effects.
Formula:C37H39NO4
InChI:InChI=1/C37H39NO4/c1-26(29-18-10-12-20-33(29)41-2)35(39)38-24-31-32(25-38)37(40,30-19-11-13-21-34(30)42-3)23-22-36(31,27-14-6-4-7-15-27)28-16-8-5-9-17-28/h4-21,26,31-32,40H,22-25H2,1-3H3/t26-,31-,32+,37+/m0/s1
Synonyms:
  • Dapitant [INN]
  • Rpr 100893
  • (3aS,4S,7aS)-Hexahydro-2-((alphaS)-o-methoxyhydratropoyl)-4-(o-methoxyphenyl)-7,7-diphenyl-4-isoindolinol
  • Rpr 103253
  • Unii-Nrd5Xf638P
  • 1H-Isoindol-4-ol, octahydro-4-(2-methoxyphenyl)-2-(2-(2-methoxyphenyl)-1-oxopropyl)-7,7-diphenyl-, (3aS-(2(R*),3aalpha,4beta,7aalpha))-
  • (2S)-1-[(3aS,4S,7aS)-4-hydroxy-4-(2-methoxyphenyl)-7,7-diphenyloctahydro-2H-isoindol-2-yl]-2-(2-methoxyphenyl)propan-1-one
  • (3aS,4S,7aS)-Octahydro-4-(2-methoxyphenyl)-2-[(2S)-2-(2-methoxyphenyl)-1-oxopropyl]-7,7-diphenyl-1H-isoindol-4-ol
  • 1H-Isoindol-4-ol, octahydro-4-(2-methoxyphenyl)-2-[(2S)-2-(2-methoxyphenyl)-1-oxopropyl]-7,7-diphenyl-, (3aS,4S,7aS)-
  • (2S)-1-[(3aS,4S,7aS)-4-hydroxy-4-(2-methoxyphenyl)-7,7-diphenyl-1,3,3a,5,6,7a-hexahydroisoindol-2-yl]-2-(2-methoxyphenyl)propan-1-one
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  • dapitant
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    dapitant

    CAS:
    <p>Dapitant, a non-peptide, selective antagonist of human NKI receptors, is representative of the 7,7,4-triarylperhydroisoindol-4-ols.</p>
    Formula:C37H39NO4
    Color and Shape:Solid
    Molecular weight:561.71

    Ref: TM-T68049

    ne
    Discontinued
    Discontinued product