CAS 153466-65-0

DICLOFENAC-D4

Description:

DICLOFENAC-D4 is a deuterated form of diclofenac, a non-steroidal anti-inflammatory drug (NSAID) commonly used to relieve pain and reduce inflammation. The "D4" designation indicates that the compound contains four deuterium atoms, which are isotopes of hydrogen, replacing the regular hydrogen atoms in the molecular structure. This modification is often used in research to trace metabolic pathways or to study drug interactions without interference from the non-deuterated form. DICLOFENAC-D4 retains the pharmacological properties of diclofenac, acting primarily as a cyclooxygenase (COX) inhibitor, which reduces the synthesis of prostaglandins involved in inflammation and pain signaling. The compound is typically characterized by its molecular weight, solubility in organic solvents, and stability under various conditions. Its applications are primarily in pharmacokinetic studies and drug metabolism research, where the deuterated label allows for precise tracking of the drug's behavior in biological systems.

Formula: C₁₄H₆D₄Cl₂NNaO₂

InChI: InChI=1/C14H11Cl2NO2.Na/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;/h1-7,17H,8H2,(H,18,19);/q;+1/p-1/i1D,2D,4D,7D;

SMILES: c1ccc(c(c1)CC(=O)O)Nc1c(cccc1Cl)Cl.[Na]

Synonyms:

• Diclofenac-D4 (Phenyl-D4)
• 2-((2,6-Dichlorophenyl)aminobenzeneacetic Acid-d4,
• Diclofenac-D4 (Major)

Diclofenac-d4

CAS: 153466-65-0

Formula: C₁₄H₇D₄Cl₂NO₂

Color and Shape: Off-White Solid

Molecular weight: 300.17

Ref: 4Z-D-061

Diclofenac-d4 (phenyl-d4)(non marqué 15307-86-5)

CAS: 153466-65-0

Purity: 98 atom % D

Color and Shape: Off-White Solid

Molecular weight: 300.18

Ref: 3U-D6183

Diclofenac D4 acid (phenyl D4) 100 µg/mL in Acetone

Controlled Product

CAS: 153466-65-0

Formula: C₁₄H₄H₇Cl₂NO₂

Color and Shape: Single Solution

Molecular weight: 300.17

Ref: 04-XA12537010AC

Diclofenac-d4

Controlled Product

CAS: 153466-65-0

Applications Labelled Diclofenac is a known nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kenny, J. R., et al.: J. Med. Chem., 47, 2816 (2004)

Formula: C₁₄₂H₄H₇Cl₂NO₂

Color and Shape: White To Light Pink

Molecular weight: 300.17

Ref: TR-D436452

Diclofenac-D4

Controlled Product

CAS: 153466-65-0

Diclofenac-D4 is a nonsteroidal anti-inflammatory drug (NSAID) that has been shown to inhibit prostaglandin synthesis. Diclofenac-D4 is a prodrug and must be activated by esterases in the gastrointestinal tract, liver, and blood before it can bind to the cyclooxygenase or peroxidase enzymes. It has been shown that NSAIDs have an effect on inflammatory diseases of the dry weight. The matrix effect is defined as the difference in response between two different matrices such as water and oil. The analytical method used for this compound was solid phase microextraction followed by gas chromatography-mass spectrometry (GC/MS). Test samples were prepared by adding 0.1 mL of aqueous-phase extract to 3 mL of methanol containing 10% acetic acid (aq.-phase) followed by sonication for 5 minutes. The samples were then heated at 60

Formula: C₁₄H₇Cl₂D₄NO₂

Purity: Min. 95%

Molecular weight: 300.17 g/mol

Ref: 3D-FD165151

DICLOFENAC-D4

CAS: 153466-65-0

Formula: C₁₄H₇Cl₂D₄NO₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 300.1733

Ref: IN-DA00AB3G