CAS 1535-73-5

3-(Trifluoromethoxy)aniline

Description:

3-(Trifluoromethoxy)aniline, with the CAS number 1535-73-5, is an organic compound characterized by the presence of both an aniline group and a trifluoromethoxy substituent. This compound features a benzene ring with an amino group (-NH2) and a trifluoromethoxy group (-O-CF3) attached at the meta position relative to each other. The trifluoromethoxy group contributes to the compound's unique properties, including increased lipophilicity and potential for enhanced reactivity in various chemical reactions. The presence of fluorine atoms often imparts distinctive electronic effects, influencing the compound's acidity, basicity, and overall stability. 3-(Trifluoromethoxy)aniline may be utilized in various applications, including pharmaceuticals, agrochemicals, and materials science, due to its functional groups that can participate in further chemical transformations. Safety data should be consulted for handling and storage, as compounds containing fluorine can exhibit specific hazards. Overall, this compound exemplifies the interplay between functional groups in determining the chemical behavior and potential applications of organic molecules.

Formula: C₇H₆F₃NO

InChI: InChI=1S/C7H6F3NO/c8-7(9,10)12-6-3-1-2-5(11)4-6/h1-4H,11H2

InChI key: InChIKey=SADHVOSOZBAAGL-UHFFFAOYSA-N

SMILES: O(C(F)(F)F)C1=CC(N)=CC=C1

Synonyms:

• (3-(Trifluoromethoxy)phenyl)amine
• 1-Trifluoromethoxy-3-aminobenzene
• 3-(Trifluoromethoxy)benzenamine
• 3-Trifluoromethoxyaniline
• 3-[(Trifluoromethyl)oxy]aniline
• Benzenamine, 3-(trifluoromethoxy)-
• Zr Coxfff
• m-(Trifluoromethoxy)aniline
• m-Amiaotrifluoromethoxybenzene
• m-Aminophenyl trifluoromethyl ether
• m-Anisidine, α,α,α-trifluoro-

3-(Trifluoromethoxy)aniline

CAS: 1535-73-5

Formula: C₇H₆F₃NO

Purity: >98.0%(GC)(T)

Color and Shape: Colorless to Yellow to Orange clear liquid

Molecular weight: 177.13

Ref: 3B-T2255

3-(Trifluoromethoxy)aniline, 98%

CAS: 1535-73-5

3-(Trifluoromethoxy)aniline may be used in chemical synthesis. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference

Formula: C₇H₆F₃NO

Purity: 98%

Color and Shape: Clear pale yellow to pale brown, Liquid

Molecular weight: 177.13

Ref: 02-A19592

3-Trifluoromethoxyaniline

CAS: 1535-73-5

Formula: C₇H₆F₃NO

Purity: 98%

Color and Shape: Liquid

Molecular weight: 177.1238

Ref: IN-DA003IAG

3-Trifluoromethoxyaniline

CAS: 1535-73-5

Formula: C₇H₆F₃NO

Molecular weight: 177.13

Ref: 7W-GK2859

3-(Trifluoromethoxy)aniline

CAS: 1535-73-5

Color and Shape: Neat

Ref: 86-MM1382.11

3-(Trifluoromethoxy)aniline

CAS: 1535-73-5

3-(Trifluoromethoxy)aniline

Formula: C₇H₆F₃NO

Purity: 98%

Color and Shape: clear. light brown liquid

Molecular weight: 177.12g/mol

Ref: 54-PC7433Z

3-(Trifluoromethoxy)aniline

CAS: 1535-73-5

Formula: C₇H₆F₃NO

Purity: 97%

Color and Shape: Liquid, Clear

Molecular weight: 177.126

Ref: 10-F001474

3-(Trifluoromethoxy)aniline

Controlled Product

CAS: 1535-73-5

Applications 3-(Trifluoromethoxy)aniline is reactant in the synthesis of pyrazolone-quinazolone hybrids as human hydroxyphenylpyruvate dioxygenase inhibitors which is a potential treatment for type I tyrosinemia.
References Xu, Y., et. al.: Bioorg. Med. Chem., 22, 5194 (2014)

Formula: C₇H₆F₃NO

Color and Shape: Neat

Molecular weight: 177.12

Ref: TR-T790715

3-(trifluoromethoxy)aniline

CAS: 1535-73-5

3-(trifluoromethoxy)aniline is a compound that contains a trifluoromethoxy group. It has been shown to have antiproliferative effects in prostate cancer cells. 3-(trifluoromethoxy)aniline inhibits the activity of pim-1, which is important for cell proliferation and differentiation. The synthesis of 3-(trifluoromethoxy)aniline can be accomplished by one of two methods. In the first method, 3-chloroaniline is reacted with trifluoroacetic acid and bis(trimethylsilyl)acetamide in dichloromethane to form 3-hydroxy-4-chlorobenzenesulfonyl chloride (3HCBSCl). In the second method, the desired product is synthesized from 3-aminophenol and trifluoroacetic acid in acetonitrile. These two methods produce different isomers

Formula: C₇H₆F₃NO

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 177.12 g/mol

Ref: 3D-FT105000