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CAS 153504-70-2

:

Cevimelinehydrochloride

Description:
Cevimeline hydrochloride is a synthetic compound primarily used as a medication to treat dry mouth, particularly in patients with Sjögren's syndrome. It acts as a muscarinic agonist, stimulating the salivary glands to increase saliva production. The chemical structure of cevimeline includes a bicyclic framework, which contributes to its pharmacological activity. It is characterized by its ability to selectively activate M3 muscarinic receptors, leading to enhanced secretion of saliva and other exocrine glands. Cevimeline hydrochloride is typically administered orally and is well-absorbed in the gastrointestinal tract. Common side effects may include sweating, nausea, and gastrointestinal discomfort, reflecting its systemic activity. The compound is generally contraindicated in patients with asthma or other respiratory conditions due to its potential to cause bronchoconstriction. Overall, cevimeline hydrochloride represents a targeted therapeutic option for alleviating symptoms of xerostomia, improving the quality of life for individuals affected by conditions that impair salivary function.
Formula:C10H18ClNOS
InChI:InChI=1/C10H17NOS.ClH/c1-8-12-10(7-13-8)6-11-4-2-9(10)3-5-11;/h8-9H,2-7H2,1H3;1H/t8-,10-;/m1./s1
SMILES:C[C@@H]1O[C@]2(CN3CCC2CC3)CS1.Cl
Synonyms:
  • CevimelineHCl
  • C07772
  • Cevimeline hydrochloride hemihydrate
  • Spiro[1-azabicyclo[2.2.2]octane-3,5'-[1,3]oxathiolane], 2'-methyl-, hydrochloride, hydrate (2:1), cis-
  • Spiro[1-azabicyclo[2.2.2]octane-3,5'-[1,3]oxathiolane], 2'-methyl-, hydrochloride, hydrate (2:2:1), (2'R,3R)-rel-
  • (2R,2'R)-2'-methylspiro[4-azabicyclo[2.2.2]octane-2,5'-[1,3]oxathiolane] hydrochloride hydrate (2:2:1)
  • (2R,2'R)-2'-methylspiro[4-azabicyclo[2.2.2]octane-2,5'-[1,3]oxathiolane] hydrochloride (1:1)
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